Resistencia antimicrobiana en staphylococcus aureus y staphylococcus epidermidis : tendencia temporal (2010-2016) y fenotipos de multirresistencia, Cartagena (Colombia).

Orozco, Raimundo Castro; Ferrer, Lucy Villafañe; Jiménez, Julio Rocha; Alvis-Guzmán, Nelson

doi:10.17151/biosa.2018.17.2.2

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…A commercial antibiotic (Amoxicillin) was taken as a positive control, a beta-lactam antibiotic used for both gram-positive and gram-negative bacteria, due to its broad spectrum of bacterial activity 1 . This antibiotic is used for antibiotic testing in the Staphylococcus and Propionibacterium families because of their sensitivity to its compounds 8,10 .…”

Section: Methodsmentioning

confidence: 99%

Antibacterial effect of Cannabidiol oil against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis and level of toxicity against Artemia salina

Pila

Segarra

Cerna

2023

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Acne is one of the most common skin pathologies; one of the causes is Propionibacterium acnes, an anaerobic and gram-positive microorganism that lives in the hair follicles of the skin and currently presents resistance to antibiotic-based treatments; this research topic has the purpose of evaluating the antibiotic activity of Cannabidiol oil against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis and the level of toxicity against Artemia salina. For the methodology, antibiograms were used by the Kirby-Bauer method, where the concentrations were evaluated: 0,8 %; 0,6 %; 0,4 %; 0,3 % and 0,1 %; Amoxicillin for positive control and Dimethyl sulfoxide (DMSO) for negative control; the percentage of inhibition against Propionibacterium acnes and two control bacteria were calculated: Staphylococcus aureus and Staphylococcus epidermidis. Once the percentage of inhibition was tested, a toxicity study was carried out against Artemia salina to determine its LD50. The Cannabidiol oil obtained from the Ecuadorian company was used as the antibiotic agent to be evaluated, and it was found that at a concentration of 0,8%, it presented a percentage of inhibition of 91,2 %; 98,7 % and 93,6 % against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis, respectively, data that do not present a significant difference against Amoxicillin; for the Artemia salina test, an LD50 of 4,8 % was obtained; taking into account that the commercial oil has a presentation of 1,6 % (500 mg/30 mL), it results in a relatively innocuous product. Thus concluding that Cannabidiol oil is a very promising antibiotic due to the inhibition percentages presented and low toxicity. Keywords: CBD, antibiograms, bioassay, LD50.

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Section: Methodsmentioning

confidence: 99%

Antibacterial effect of Cannabidiol oil against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis and level of toxicity against Artemia salina

Pila

Segarra

Cerna

2023

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In vitroactivity of the antimicrobial peptide AP7121 against the human methicillin-resistant biofilm producersStaphylococcus aureusandStaphylococcus epidermidis

Delpech

Ceci²,

Lissarrague

et al. 2020

Biofouling

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Chemistry and Bioactivity of Microsorum scolopendria (Polypodiaceae): Antioxidant Effects on an Epithelial Damage Model

et al. 2022

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Microsorum scolopendia (MS), which grows on the Chilean island of Rapa Nui, is a medicinal fern used to treat several diseases. Despite being widely used, this fern has not been deeply investigated. The aim of this study was to perform a characterization of the polyphenolic and flavonoid identity, radical scavenging, antimicrobial, and anti-inflammatory properties of MS rhizome and leaf extracts (RAE and HAE). The compound identity was analyzed through the reversed-phase high-performance liquid chromatography (RP-HPLC) method coupled with mass spectrometry. The radical scavenging and anti-inflammatory activities were evaluated for DPPH, ORAC, ROS formation, and COX inhibition activity assay. The antimicrobial properties were evaluated using an infection model on Human Dermal Fibroblast adult (HDFa) cell lines incubated with Staphylococcus aureus and Staphylococcus epidermidis. The most abundant compounds were phenolic acids between 46% to 57% in rhizome and leaf extracts, respectively; followed by flavonoids such as protocatechic acid 4-O-glucoside, cirsimaritin, and isoxanthohumol, among others. MS extract inhibited and disaggregated the biofilm bacterial formed and showed an anti-inflammatory selective property against COX-2 enzyme. RAE generated a 64% reduction of ROS formation in the presence of S. aureus and 87.35% less ROS in the presence of S. epidermidis on HDFa cells. MS has great therapeutic potential and possesses several biological properties that should be evaluated.

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Resistencia antimicrobiana en staphylococcus aureus y staphylococcus epidermidis : tendencia temporal (2010-2016) y fenotipos de multirresistencia, Cartagena (Colombia).

Cited by 3 publications

References 24 publications

Antibacterial effect of Cannabidiol oil against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis and level of toxicity against Artemia salina

Antibacterial effect of Cannabidiol oil against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis and level of toxicity against Artemia salina

In vitroactivity of the antimicrobial peptide AP7121 against the human methicillin-resistant biofilm producersStaphylococcus aureusandStaphylococcus epidermidis

Chemistry and Bioactivity of Microsorum scolopendria (Polypodiaceae): Antioxidant Effects on an Epithelial Damage Model

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