Resistencia a ertapenem en 2 instituciones hospitalarias de alto nivel de complejidad: microbiología, epidemiología y factores de riesgo

Maldonado, Natalia; Castro, Bibiana; Berrío, Indira; Manjarrés, Miguel; Robledo, Carlos; Robledo, Jaime

doi:10.1016/j.eimc.2015.11.009

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…It was associated with β‐lactamase activity and porin alteration in clinical Enterobacteriaceae isolates 27 . In a Spanish case–control study for ertapenem resistant and susceptible entererobactericea infections, prior ertapenem use was almost four times higher in the resistant group 29 . In our study, three patients had ertapenem resistant K .…”

Section: Discussionmentioning

confidence: 47%

“…27 In a Spanish case-control study for ertapenem resistant and susceptible entererobactericea infections, prior ertapenem use was almost four times higher in the resistant group. 29 In our study, three patients had ertapenem resistant K. pneumoniae infection after completing the episodes, all with urinary instruments and two receiv- The patients completed the planned course in 78.8% of daily inpatient ertapenem episodes. The hospitalization rate because of clinical failure (3.8%) and adverse events (1.2%) was low.…”

Section: Discussionmentioning

confidence: 75%

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Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID‐19 pandemic

et al. 2021

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Background: Physicians hospitalize the patients with complicated urinary tract infections (cUTIs) when they need intravenous antibiotics and outpatient parenteral antimicrobial therapy (OPAT) is unavailable. Daily inpatient antimicrobial therapy is an alternative to hospitalization, which is similar to OPAT; patients go home after they are administered antibiotics in a separate room in the hospital setting.Objectives: We assessed our previous daily inpatient practice to revitalize the model in the COVID-19 era. Materials and Methods:We retrospectively evaluated the clinical and microbiological responses and the cost effectiveness of the patients with cUTIs who received daily inpatient ertapenem therapy. Results:Our study population was 136 patients in 156 episodes. It was a difficultto-treat group with older age (mean 63.0 ± 14.8 years) and a high burden of underlying conditions (86.5%). The most common causative organisms were Escherichia coli (74.4%) and Klebsiella pneumoniae (19.2%); 89.7% of the isolates were producing extended-spectrum beta lactamase (ESBL). The microbiologic and clinical success rates were 82.1% and 95.5%, respectively. The patients required hospitalization in 16 episodes (10.2%) because of clinical failures (3.8%), superinfections (2%), planned invasive interventions (3.2%), and side effects (1.2%). Our university hospital saved 1608 bed-days and 2596 € (9702 TL) bed costs. Conclusions:In the COVID-19 pandemic period, this seems to be an effective, safe, and cost-effective way to decrease hospitalizations for cUTIs in settings where OPAT is unavailable. What's known• Antimicrobial resistance in the complicated urinary tract infections is a global challenge for optimal antimicrobial treatment.• Hospitalization of these patients has increased the cost, risk of transmissions of COVID-19, and infections.• Ertapenem is suitable for outpatient parenteral antimicrobial therapy (OPAT).How to cite this article: Nazli Zeka A, Avkan-Oguz V, Irmak C, et al. Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID-19 pandemic. Int J Clin Pract.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 75%

Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID‐19 pandemic

et al. 2021

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Crise sanitaire liée au COVID-19 : modalités du traitement de l’appendicite aiguë non compliquée de l’adulte par antibiothérapie seule comme alternative à l’appendicectomie

Collard

Lakkis

Loriau

et al. 2020

Journal de Chirurgie Viscérale

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Collard et al. à considérer ce cas particulier. En effet, tandis que le traitement recommandé de l'appendicite aiguë non compliquée est chirurgical, l'alternative non chirurgicale par antibiothérapie seule a été largement évaluée dans la littérature au cours de travaux de qualité. Dans la mesure où la limite principale du traitement médical exclusif de l'appendicite aiguë non compliquée est le risque de récidive à distance, cette option thérapeutique représente une alternative de choix pour réduire la surcharge intrahospitalière dans ce contexte de crise sanitaire. L'objectif de ce travail est donc de mettre à disposition des médecins et des chirurgiens un guide pratique issu d'une analyse de la littérature sur le traitement médical de l'appendicite aiguë non compliquée de l'adulte afin de pouvoir proposer ce traitement alternatif aux bons patients et dans des bonnes conditions, notamment lorsque l'accès au bloc opératoire est impossible.

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Appendicite de l’adulte : recommandations pour la pratique clinique de la Société française de chirurgie digestive (SFCD) et de la Société d’imagerie abdominale et digestive (SIAD)

Collard

Christou

Lakkis

et al. 2020

Journal de Chirurgie Viscérale

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Resistencia a ertapenem en 2 instituciones hospitalarias de alto nivel de complejidad: microbiología, epidemiología y factores de riesgo

Cited by 6 publications

References 10 publications

Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID‐19 pandemic

Daily inpatient ertapenem therapy can be an alternative to hospitalization for the treatment of complicated urinary tract infections during the COVID‐19 pandemic

Crise sanitaire liée au COVID-19 : modalités du traitement de l’appendicite aiguë non compliquée de l’adulte par antibiothérapie seule comme alternative à l’appendicectomie

Appendicite de l’adulte : recommandations pour la pratique clinique de la Société française de chirurgie digestive (SFCD) et de la Société d’imagerie abdominale et digestive (SIAD)

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