Resistencia a antibióticos no betalactámicos de aislamientos invasores de Streptococcus pneumoniae en niños latinoamericanos: SIREVA II, 2000-2005

Agudelo, Clara Inés; Castañeda, Elizabeth; Corso, Alejandra; Regueira, Mabel; Brandileone, Maria Cristina de Cunto; Brandão, Angela Pires; Maldonado, Aurora; Hormázabal, Juan Carlos; Tamargo, Isis; Echániz-Avilés, Gabriela; Soto, Araceli; Viveros, Monica; Hernández, Irma A. González; Chamorro, Gustavo; Weiler, Natalie; Sánchez, Jacqueline; Feris, Jesús M; Camou, Teresa; García, Gabriela; Spadola, Enza; Payares, Daisy; Gabastou, Jean-Marc; Fabio, José Luis Di; Fossati, Sofía; Gagetti, Paula; Rodríguez, Marisa; Chávez, Elsa; Guerra, Maria Luiza Leopoldo Silva; Almeida, Samanta Cristine Grassi; Heitmann, Ingrid; Rojas, B; García, Julián Pérez; Lagos, Rosanna; Seoane, Mabel; Sanabria, Olga; Ovalle, María Victoria; Moreno, Jaime; Hoz, Fernando de la; Pastor, Desireé; Monrás, Miriam Pérez; Peraza, Gilda Toraño; Gort, Kiomy Fuentes; Hernández, Alina Llops; Sambrano, Andrés; Carnalla-Barajas, María Noemí; Velázquez-Meza, María Elena; Arredondo-Garcı́a, José Luis; Solórzano-Santos, Fortino; Sánchez-Francia, Domingo; Noriega, Patricia Gabino; Moreno, Susana Jiménez; González, Enrique; Contreras, Sugei Janette Gámez; García, Marco Antonio González; Franco, Rossana; Gómez, Gloria; Ortellado, Juana; Leguizamón, Myrian; Quiñónez, Beatriz; Peña, Chabela; Coradin, Hilma; Fernández, Josefina; Novas, Mirna; Tolari, Gilda; Giffoni, Gabriel Pérez; Albini, María; Félix, Viviana; Hortal, María; Fernández, Coral; Sánchez, Damarys

doi:10.1590/s1020-49892009000400004

Cited by 16 publications

(5 citation statements)

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“…However, surveys of essential medicines in developing countries show wide variability in the actual price of ceftriaxone and its availability in public hospitals, suggesting that penicillins may still be used for first-line treatment in some countries [10]. Pneumococcal resistance to cephalosporins needs to be monitored [31,32], although cefotaxime nonsusceptibility has not been associated with increased mortality of pneumococcal meningitis treated with cefotaxime [33-35]. …”

Section: Discussionmentioning

confidence: 99%

Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study

et al. 2011

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BackgroundPrior to the availability of generic third-generation cephalosporins, penicillins were widely used for treatment of pneumococcal meningitis in developing countries despite concerns about rising levels of penicillin resistance among pneumococcal isolates. We examined the impact of penicillin resistance on outcomes of pneumococcal meningitis over a ten year period in an infectious diseases hospital in Brazil.MethodsClinical presentation, antimicrobial therapy and outcomes were reviewed for 548 patients with culture-confirmed pneumococcal meningitis from December, 1995, to November, 2005. Pneumococcal isolates from meningitis patients were defined as penicillin-resistant if Minimum Inhibitory Concentrations for penicillin were greater than 0.06 μg/ml. Proportional hazards regression was used to identify risk factors for fatal outcomes.ResultsDuring the ten-year period, ceftriaxone replaced ampicillin as first-line therapy for suspected bacterial meningitis. In hospital case-fatality for pneumococcal meningitis was 37%. Of 548 pneumococcal isolates from meningitis cases, 92 (17%) were resistant to penicillin. After controlling for age and severity of disease at admission, penicillin resistance was associated with higher case-fatality (Hazard Ratio [HR], 1.62; 95% Confidence Interval [CI], 1.08-2.43). Penicillin-resistance remained associated with higher case-fatality when initial therapy included ceftriaxone (HR, 1.68; 95% CI 1.02-2.76).ConclusionsFindings support the use of third generation cephalosporin antibiotics for treatment of suspected pneumococcal meningitis even at low prevalence of pneumococcal resistance to penicillins.

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Section: Discussionmentioning

confidence: 99%

Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study

et al. 2011

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“…La Organización Panamericana de la Salud (OPS), a partir del año 1993 desarrolló un programa regional de vigilancia de laboratorio denominado SIREVA (Sistema de Redes de Vigilancia de los Agentes Responsables de Neumonias y Meningitis Bacterianas), el que a través de los años ha ido evolucionando desde el punto de vista técnico y de cobertura de patógenos meníngeos (3). La Red SIREVA ha sido un gran apoyo en el fortalecimientode los sistemas de vigilancia locales para infecciones invasoras por S. pneumoniae, y en especial en el aporte de información de laboratorio estandarizada, permitiendo la comparación de datos entre países y la emisión de información de calidad aceptada por la comunidad científica internacional (3,4,5,6,7). A partir de esta red, Chile ha adquirido la experiencia técnica conducente a la calidad de la vigilancia de laboratorio de S. pneumoniae.…”

Section: Discussionunclassified

Evaluación de la Vigilancia de Laboratorio de Streptococcus pneumoniae proveniente de la Enfermedad Invasora en Chile: 2009-2014

Valenzuela¹,

Ríos

Díaz³

et al. 2017

Rev. Inst. Salud Pública Chile

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Introducción: Este estudio consistió en conocer la calidad de los métodos de laboratorio y la competencia técnica para el diagóstico de Streptococcus pneumoniae en ENI, en tres regiones de Chile, las que incluyen el 63% de la población: Metropolitana, Valparaíso y Biobío. Material y método: Se estructuró y validó una encuesta que se aplicó en terreno a los 18 laboratorios correspondientes a estas tres regiones, la que incluyó antecedentes generales del Establecimiento de salud y del laboratorio de Microbiología, datos sobre los casos de Streptococcus pneumoniae a nivel local, número de muestras de estos casos que fueron derivadas al laboratorio de referencia nacional y cuantas de ellas fueron confirmadas y serotipificadas. Resultados: El número de cepas positivas en el nivel local y el número y porcentaje de ellas que se recibe en el Laboratorio de Referencia Nacional, fluctuó entre 86,0% y 76,6%; se evidenció que existe un bajo porcentaje de muestras que se contaminan en el nivel local. Se observó una disminución del 50,4% de casos de ENI entre los períodos 2009 (204 casos) al 2014 (101 casos); mientras que la cantidad de casos atendidos en Pediatría básica disminuyó de forma significativa, alcanzando el 72,6 % entre los años 2009 a 2014 (102 y 28 casos respectivamente). Conclusiones: La evaluación de la vigilancia demostró una alta adherencia de los laboratorios a las normas técnicas. El porcentaje de muestras contaminadas tanto en muestras pediátricas como de adultos, estuvo por debajo de lo aceptado internacionalmente en pacientes hospitalizados.

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“…In Argentina, although prevalence of erythromycin resistance in streptococci is still low, it has increased significantly in recent years in most regions [9,[13][14][15]. In previous work carried out in Bariloche we found low overall resistance rates for S. pyogenes, but a significant rise in resistance in one particular population group [9].…”

Section: Introductionmentioning

confidence: 92%

Trends in Macrolide Resistance for Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus pneumoniae and its Association with Social Clustering in Argentina

Rubinstein¹

2011

TOANTIMJ

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Abstract:The aim of this work was to study and compare macrolide resistance patterns among Streptococcus pneumoniae, Streptococcus agalactiae and Streptococcus pyogenes, to describe the phenotypes of macrolide-lincosamide resistance and to further investigate associations between macrolide resistance and social clustering. Susceptibility data were obtained from 4 clinical microbiology laboratories in Bariloche, Argentina for the period 2002-2008. Patients were differentiated in two population clusters according to the institution they attended (public or private). A total of 4310 strains were studied: 2615 S. pyogenes, 995 S. agalactiae and 700 isolates of S.pneumoniae. Erythromycin resistance rates over the study period were 1.5% for S. pyogenes, 7.8% for S. agalactiae and 11.3% for S. pneumoniae. For the complete study group, these values differed significantly among species (contingency table 2 = 164.52, p<0.0001). Resistance in S.pyogenes and S. pneumoniae showed irregular trends whilst S. agalactiae showed an increasing tendency during the whole period appearing to be a better indicator of the trends in macrolide resistance. A dual character MLS B phenotype of both inducible and constitutive resistance was observed in S. agalactiae only. Resistance in isolates from the population attending private institutions was significantly higher than those attending the public hospital (S. pyogenes, (1.9 vs. 0.6, 2 = 5.851, p<0.025); S. pneumoniae, 19.1 vs. 7.0 ( 2 = 21.98, p<0.001), and. S. agalactiae, 12.4 vs. 3.8 ( 2 = 24.5, p<0.001)). In conclusion, macrolides resistance rates during 2002-2008 were significantly different for S. pyogenes, S. agalactiae and S.pneumoniae. We also found significant variations in macrolide resistance levels in different population groups.

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Resistencia a antibióticos no betalactámicos de aislamientos invasores de Streptococcus pneumoniae en niños latinoamericanos: SIREVA II, 2000-2005

Abstract: High and increasing rates of isolates resistant to TMP-SMZ and erythromycin were observed, as well as a decreasing percentage of isolates resistant to chloramphenicol. These trends highlight differences among the countries studied.

Cited by 16 publications

References 18 publications

Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study

Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study

Evaluación de la Vigilancia de Laboratorio de Streptococcus pneumoniae proveniente de la Enfermedad Invasora en Chile: 2009-2014

Trends in Macrolide Resistance for Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus pneumoniae and its Association with Social Clustering in Argentina

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