Resistant starch slows the progression of CKD in the 5/6 nephrectomy mouse model

Karaduta, Oleg; Glazko, Galina V.; Dvanajscak, Zeljko; Arthur, John M.; Mackintosh, Samuel G.; Orr, Lisa; Rahmatallah, Yasir; Yeruva, Laxmi; Tackett, Alan J.; Zybailov, Boris

doi:10.14814/phy2.14610

Cited by 16 publications

(15 citation statements)

References 39 publications

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“…The development of hypertension and renal damage associated to HFDs also have a link with changes in gut microbiota [55][56][57]. However, the outcomes of these cardiometabolic and renal diseases could be improved by the use of pro-and prebiotics with the diet [58,59].…”

Section: Discussionmentioning

confidence: 99%

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Domínguez-Vías

Segarra

Ramírez-Sánchez

et al. 2021

IJMS

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High saturated fat diets have been associated with the development of obesity and hypertension, along with other pathologies related to the metabolic syndrome. In contrast, the Mediterranean diet, characterized by its high content of monounsaturated fatty acids, has been proposed as a dietary factor capable of positively regulating cardiovascular function. These effects have been linked to changes in the local renal renin angiotensin system (RAS) and the activity of the sympathetic nervous system. The main goal of this study was to analyze the role of two dietary fat sources on aminopeptidases activities involved in local kidney RAS. Male Wistar rats (six months old) were fed during 24 weeks with three different diets: the standard diet (S), the standard diet supplemented with virgin olive oil (20%) (VOO), or the standard diet enriched with butter (20%) plus cholesterol (0.1%) (Bch). Kidney samples were separated in medulla and cortex for aminopeptidase activities (AP) assay. Urine samples were collected for routine analysis by chemical tests. Aminopeptidase activities were determined by fluorometric methods in soluble (sol) and membrane-bound (mb) fractions of renal tissue, using arylamide derivatives as substrates. After the experimental period, the systolic blood pressure (SBP) values were similar in standard and VOO animals, and significantly lower than in the Bch group. At the same time, a significant increase in GluAP and IRAP activities were found in renal medulla of Bch animals. However, in VOO group the increase of GluAP activity in renal medulla was lower, while AspAP activity decreased in the renal cortex. Furthermore, the VOO diet also affected other aminopeptidase activities, such as TyrAP and pGluAP, related to the regulation of the sympathetic nervous system and the metabolic rate. These results support the beneficial effect of VOO in the regulation of SBP through changes in local AP activities of the kidney.

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Section: Discussionmentioning

confidence: 99%

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Domínguez-Vías

Segarra

Ramírez-Sánchez

et al. 2021

IJMS

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“…However, perturbations of gut microbiota of adult mothers failed to significantly impair their sociability and preference for social novelty. These observations suggest that alterations in the gut microbiota during the critical early developmental periods have been associated with changed behavioral phenotypes in our mice and other mouse models [ 48 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 62%

Maternal Gut Dysbiosis Alters Offspring Microbiota and Social Interactions

Zhang

Xue

et al. 2021

Microorganisms

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Increasing application of antibiotics changes the gut microbiota composition, leading to dysbiosis of the gut microbiota. Although growing evidence suggests the potential role of gut dysbiosis as the cause of neurodevelopmental disorders and behavioral defects, a broad gap of knowledge remains to be narrowed to better understand the exact mechanisms by which maternal gut dysbiosis alters microbiota development and social interactions of offspring. Here, we showed that maternal gut dysbiosis during gestation is a critical determinant of gut microbiota and social interactions off mouse offspring. Gut microbiota of 2-week-old offspring showed significant changes in response to maternal antibiotic treatment. We even detected distinct effects of maternal oral antibiotics on gut microbiota of 14-week-old offspring. Compared to controls, offspring born to antibiotics-treated mothers displayed reduction in sociability and preference for social novelty, suggesting that the altered offspring social behavior was closely linked to dysbiosis of maternal gut microbiota. Our study opens the possibility to better understand the mechanism of how maternal gut microbiota vertically impairs social interactions of offspring in animal models, providing support to the maternal gut microbiota as a potential mediator between offspring microbiota and behaviors.

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“…Such studies are challenging for multiple reasons, including the presence of fecal or soil-derived substances that interfere with sample preparation and the high abundances of host-associated proteins that potentially swamp out the microbial signal. This particular multi-step database search strategy was used in PEAKS Studio (Bioinformatics Solutions) to arrive at the final list of identified proteins [25]. At the first step, PEAKS generates de novo peptide sequence tags from the raw mass spectra without the use of any sequence database.…”

Section: Metaproteomics Pipelinementioning

confidence: 99%

Metaproteomics—An Advantageous Option in Studies of Host-Microbiota Interaction

Karaduta¹,

Dvanajscak

Zybailov³

2021

Microorganisms

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Gut microbiome contributes to host health by maintaining homeostasis, increasing digestive efficiency, and facilitating the development of the immune system. Manipulating gut microbiota is being recognized as a therapeutic target to manage various chronic diseases. The therapeutic manipulation of the intestinal microbiome is achieved through diet modification, the administration of prebiotics, probiotics, or antibiotics, and more recently, fecal microbiome transplantation (FMT). In this opinion paper, we give a perspective on the current status of application of multi-omics technologies in the analysis of host–microbiota interactions. The aim of this paper was to highlight the strengths of metaproteomics, which integrates with and often relies on other approaches.

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Resistant starch slows the progression of CKD in the 5/6 nephrectomy mouse model

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 16 publications

References 39 publications

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Maternal Gut Dysbiosis Alters Offspring Microbiota and Social Interactions

Metaproteomics—An Advantageous Option in Studies of Host-Microbiota Interaction

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