Resistant starch intake partly restores metabolic and inflammatory alterations in the liver of high-fat-diet-fed rats

NMR-based metabolomics highlights differences in plasma metabolites in pigs exhibiting diet-induced differences in adiposity

“…Irrespective of line, there was a marked decrease in BW and body fat content with the HF diet. This observation is in agreement with previous studies showing a negative effect of fibre inclusion in high-fat diet on adiposity in pigs [26,27] and rats [28]. Fig.…”

“…Altogether, these findings support the view that the HF diet can drive different metabolic changes at the hepatic level. Similar conclusions have been drawn in rats for resistant starch consumption in the context of a high-fat diet [28].…”

“…In contrast, it has been demonstrated that pigs acutely fed a diet enriched in insoluble or soluble fibres had lower postprandial plasma TAG concentrations [30]. In rats, the addition of fibre to a high-fat diet also reduced these concentrations [28]. In the current study, the increase in both circulating TAG and VLDL may be an adaptive response of the liver to provide energy to peripheral tissues.…”

The Therapeutic Potential of Resistant Starch in Modulation of Insulin Resistance, Endotoxemia, Oxidative Stress and Antioxidant Biomarkers in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

“…Prebiotics via several mechanisms can improve glycemic status and inflammation. Suppression of the levels of free fatty acids (FFAs) through short-chain fatty acids (acetate, propionate and butyrate) [23] returns to the basal expression levels of transcription factors involved in lipogenesis (sterol regulatory element-binding protein [SREBP-1c]), cholesterol metabolism (SREBP-2, liver X receptors) and fatty acid oxidation (peroxisome proliferator-activated receptor alpha [24] ), reductions of endotoxin levels [25] and decreased oxidative stress [26] , which could improve insulinemic effects. Non-significant changes in FPG may be attributed to lack of RS effect, as a prebiotic, on basal hepatic glucose production [27] .…”

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

“…It is well documented that resistant starch (RS) administration could improve the glucose intolerance and insulin resistance [4,5]. However, the mechanisms (especially at the molecular level) by which this takes place are still not fully clear [6]. A recent report demonstrated for the first time that at least part of the beneficial effects of a higher level of RS intake (419 g/kg diet) in the context of a high-fat feeding could be driven by changes elicited at the hepatic level [6].…”