Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue

Harazaki, Tomomi; Inoue, Seiya; Imai, Chihiro; Mochizuki, Kazuki; Goda, Toshinao

doi:10.1016/j.nut.2013.10.020

Cited by 47 publications

(33 citation statements)

References 35 publications

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“…MDA is produced from ROS, and the higher level of MDA promotes polyunsaturated fatty acids peroxidation, and the evidence also shows strong relations between MDA levels and different pathological stages of diabetes [26]. Although the ability of RS to modulate the expression level of oxidative stress related genes did not measure in this study, newly published data showed that replacing regular starch with RS in the diet could improve insulin resistance at an early stage by reducing inflammation associated with the presence of macrophages expressing CD11c in adipose tissues at mRNA and protein level [27].…”

Section: Discussionmentioning

confidence: 85%

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

Zhou

Wang

Ren

et al. 2015

International Journal of Biological Macromolecules

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Section: Discussionmentioning

confidence: 85%

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

Zhou

Wang

Ren

et al. 2015

International Journal of Biological Macromolecules

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“…Animal studies were able to demonstrate the beneficial effects of RS consumption on fat metabolism and glucose and insulin tolerance. For instance, Harazaki et al fed obese rats with a diet with 55% (w/w) high‐amylose maize type‐2 RS (HAM‐RS2) for 4 weeks and observed improvements in insulin sensitivity, when compared with rats fed the control diet (55% cornstarch instead of HAM‐RS2). They also found that the size of the mesenteric adipocytes in RS2‐fed rats was smaller than those fed the control diet.…”

Section: Effects Of Resistant Starch Consumption Leading To Improved mentioning

confidence: 99%

The relationship between resistant starch and glycemic control: A review on current evidence and possible mechanisms

Wong

Louie

2016

Starch Stärke

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Good glycemic control, which is vital for patients with type 2 diabetes, can be achieved via dietary intervention. Resistant starch (RS) is a type of carbohydrate that largely resists digestion in the small intestine. Instead, it is fermented by the gut microbiota that resides in the large intestine into short-chain fatty acids (SCFAs), which are found to have beneficial effects on human glucose metabolism. Here, an overview is provided of the classification of different types of RS, as well as the fermentation process of RS by the gut microbiota. The effects of RS consumption that contribute to glycemic control are then discussed with reference to animal and human studies. Although beneficial effects of RS consumption have been observed, results from animal and human studies are inconclusive regarding the mechanisms behind them. Additional research effort is necessary in order to have a better understanding of the effects of habitual RS consumption on glycemic control.

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“…In particular, Zhou et al observed significant decreases in blood glucose levels compared to controls when RS2 (8% w/w) was fed to streptozotocin-induced diabetic rats [10]. This was in contrast to Harazaki et al who reported that feeding RS2 (55% w/w) significantly decreased fasting insulin levels and the index of insulin resistance but did not change glucose tolerance in an OLETF rat model of T2D [11*]. …”

Section: Resistant Starches To Combat Metabolic Diseasesmentioning

confidence: 99%

“…The aforementioned work by Harazaki et al describing reduced insulinemia in RS2-fed T2D rats was the first to report a potential link between RS and regulation of immune cell populations. Specifically, feeding RS was associated with decreased adipose tissue expression of CD11c, a marker expressed on antigen presenting cells and pro-inflammatory macrophages [11*]. This finding is of considerable interest, as deletion of CD11c expressing cells has previously been shown to normalize insulin sensitivity in obese, insulin-resistant animals [32].…”

Section: Mechanisms Underpinning the Health Effects Of Rsmentioning

confidence: 99%

Resistant starches for the management of metabolic diseases

Bindels

Walter

Ramer‐Tait

2015

Current Opinion in Clinical Nutrition and Metabolic Care

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Purpose of review Recent clinical trials and animal studies indicate that resistant starches (RS) may be beneficial therapeutic tools for the management of metabolic diseases. The purpose of this review is to summarize these findings and discuss the established and proposed mechanisms by which RS exert their benefits. We also examine open questions regarding how RS improve metabolism and propose future research directions for the field. Recent findings Data from both humans and animal models clearly support a role for RS in improving a variety of metabolic features; however, discrepancies do exist regarding specific effects. Concomitant improvements in both insulin levels and body fat depots are often reported in rodents fed RS whereas RS feeding in humans improves insulin sensitivity without having a major impact on fat mass. These differences could be explained by the coexistence of several mechanisms (both gut microbiota-dependent and gut microbiota-independent) underpinning the metabolic benefits of RS. Summary Together, the studies presented in this review offer new insights into the potential pathways by which RS enhance metabolic health, including modulation of the gut microbiota, gut peptides, circulating inflammatory mediators, innate immune cells, and the bile acid cycle.

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Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue

Cited by 47 publications

References 35 publications

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats

The relationship between resistant starch and glycemic control: A review on current evidence and possible mechanisms

Resistant starches for the management of metabolic diseases

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