Resistant Starch Bagels Reduce Fasting and Postprandial Insulin in Adults at Risk of Type 2 Diabetes

Abstract

These data suggest that consumption of a high-HAM-RS2 bagel improves glycemic efficiency by reducing the amount of insulin required to manage postprandial glucose while improving fasting insulin sensitivity in adults at increased risk of T2D. This research provides support for a feasible dietary strategy for T2D risk reduction. This trial was registered at clinicaltrials.gov as NCT02129946.

A Randomized Placebo Controlled Clinical Trial to Determine the Impact of Digestion Resistant Starch MSPrebiotic® on Glucose, Insulin, and Insulin Resistance in Elderly and Mid-Age Adults

“…Previous studies have examined the blood glucose-lowering and insulin-sensitizing potential of DRS prebiotics ( 11 , 13 , 15 , 21 , 34 ). These studies examined the role of DRS as a carbohydrate replacement in food rather than as a supplement, where at least some of the effects on blood glucose level can be attributed to differences in the amount of digestible starch.…”

“…These studies examined the role of DRS as a carbohydrate replacement in food rather than as a supplement, where at least some of the effects on blood glucose level can be attributed to differences in the amount of digestible starch. While connections between DRS consumption and improved insulin sensitivity have been reported, they do not necessarily translate to lower blood glucose levels ( 15 , 18 , 19 ). In healthy people, this should not be surprising, given that the body will adapt by generating glucose via gluconeogenesis to prevent hypoglycemia in those with proper glycemic control ( 11 ).…”

“…However, this is difficult when there are no defined “healthy” levels of such metabolites, and current testing methods do not take into consideration the rapid absorption of such metabolites (e.g., short chain fatty acids). Although many of the health effects of probiotics and prebiotics have been linked to modulation of the gut microbiome, a limited number of clinical trials have been conducted in humans investigating the tolerability or function of DRS as a prebiotic ( 4 , 11 , 13 , 15 , 17 , 28 , 35 , 38 ). Our recent publication focused on the microbiome changes in both mid-age (MID) and ELD adult groups after 3 months of consuming MSPrebiotic ® DRS.…”

Comparison of intake of food groups between participants with normoglycemia, impaired fasting glucose, and type 2 diabetes in PURE Poland population

“…Meta-analysis conducted by Yao et al [18] concludes that increased intake of dietary fiber is associated with lower risk of development of type 2 diabetes. In a randomized, double-blind study conducted by Dainty et al [19], participants who consumed bagels rich in resistant starch in comparison with participants who consumed regular bread were characterized by lower fasting and postprandial insulin levels and lower fasting insulin resistance. Participants with IFG consumed more fruit juices than either normoglycemic or diabetic participants.…”

Effect of resistant starch supplementation on blood lipids in metabolic disorder adults: A meta analysis of randomized controlled trials

“…25 From the previous studies, RS played a useful role in health by some potential mechanisms include: ① changes in intestinal microbiota, ② a reduction in insulin, ③ resistance rise in HDL-c concentrations, and ④ an increase in SCFAs production. [3][4][5][6][26][27][28][29][30][31][32][33][34] RS could produce SCFAs through two pathways: directly (RS fermentation) or indirectly (increasing colonic butyrate-producing microbiota such as Lachnospiraceae and Ruminococcaceae). Butyrate can control macrophage activity and expression of NF-κB which is the main inflammatory and immune response.…”