Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease

Drake, Anna M.; Coughlan, Melinda T.; Christophersen, Claus T.; Snelson, Matthew

doi:10.3390/nu14214547

Cited by 12 publications

(8 citation statements)

References 149 publications

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“…Previous studies have revealed that the supplementation of dietary fiber reduced serum levels of uremic toxins and proinflammatory cytokines, and reversed kidney injuries in CKD (Chiavaroli et al, 2015;Felizardo et al, 2019;Zhong et al, 2021). Similarly, recent studies indicated that dietary fiber ameliorates diabetes-related dysbiosis and protect against DKD through promoting SCFA-producing bacteria, which are able to attenuate inflammatory and oxidative stress (Drake et al, 2022;Li et al, 2020;Lv et al, 2022).…”

Section: Dietmentioning

confidence: 98%

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

Zhao

Zhāng

et al. 2023

Front. Physiol.

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Diabetic kidney disease (DKD) is a common complication in patients with diabetes mellitus (DM). Increasing evidence suggested that the gut microbiota participates in the progression of DKD, which is involved in insulin resistance, renin-angiotensin system (RAS) activation, oxidative stress, inflammation and immunity. Gut microbiota-targeted therapies including dietary fiber, supplementation with probiotics or prebiotics, fecal microbiota transplantation and diabetic agents that modulate the gut microbiota, such as metformin, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose transporter-2 (SGLT-2) inhibitors. In this review, we summarize the most important findings about the role of the gut microbiota in the pathogenesis of DKD and the application of gut microbiota-targeted therapies.

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Section: Dietmentioning

confidence: 98%

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

Zhao

Zhāng

et al. 2023

Front. Physiol.

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“…In addition, lifestyle intervention, such as dietotherapy and exercise training, is also a common strategy for DN therapy. Dietary fiber was proved to attenuate the progression of DN by promoting the expansion of SCFAs-producing bacteria, such as Prevotella and Bifidobacterium , which can inhibit inflammation and oxidative stress ( Li Y. J. et al, 2020 ; Drake et al, 2022 ). In STZ-induced DN rats, Mulberry leaf tea markedly ameliorated hyperglycemia and renal injury by restoring the abundance of Adlercreutzia , Anaerofustis , Coprococcus , Dorea , Roseburia , Oscillospira , Phascolarctobacterium , Coprobacillus , Sutterella and RF39 , which indicated that Mulberry leaf tea can be used as a dietotherapy for DN therapy through gut–kidney axis ( Sheng et al, 2018 ).…”

Section: Gut Microbiota-targeted Dn Therapiesmentioning

confidence: 99%

The roles of gut microbiota and its metabolites in diabetic nephropathy

Zhao¹,

Yang²,

Tian³

et al. 2023

Front. Microbiol.

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Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk of renal failure and causes a high global disease burden. Due to the lack of sustainable treatment, DN has become the primary cause of end-stage renal disease worldwide. Gut microbiota and its metabolites exert critical regulatory functions in maintaining host health and are associated with many pathogenesis of aging-related chronic diseases. Currently, the theory gut–kidney axis has opened a novel angle to understand the relationship between gut microbiota and multiple kidney diseases. In recent years, accumulating evidence has revealed that the gut microbiota and their metabolites play an essential role in the pathophysiologic processes of DN through the gut–kidney axis. In this review, we summarize the current investigations of gut microbiota and microbial metabolites involvement in the progression of DN, and further discuss the potential gut microbiota-targeted therapeutic approaches for DN.

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“…Senescence is largely promoted by the chronic low-grade inflammation that is a feature of prediabetes [117]. In this context, prediabetic people frequently have elevated levels of various inflammatory mediators, including interleukin-1 beta (IL-1β), interleukin-18 (IL-18), and high-sensitivity C-reactive protein (hs-CRP) [131]. The systemic inflammation that accelerates aging is largely caused by these inflammatory factors [132].…”

Section: Chronic Inflammation and Its Implications For Senescencementioning

confidence: 99%

Identification of Putative Causal Relationships Between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review

Mbatha,

Mushebenge,

Khathi

2023

Preprint

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Prediabetes, a pivotal phase in glucose metabolism between normalcy and diabetes, exerts a profound influence on the aging process and the risk of age-related diseases. This comprehensive review delves into the intricate web of blood-based biomarkers that collectively expedite senescence, marking the transition from a state of health to age-related complications. Key findings underscore the significance of diverse biomarkers, such as telomere length, p16INK4a, senescence-associated secretory phenotype (SASP) factors, DNA methylation clocks, advanced glycation end products (AGEs), inflammatory and oxidative stress markers, circulating hormones, and additional factors like folate, B12, osteocalcin, and more. Not only do these biomarkers serve as indicators of senescence, but they actively fuel chronic inflammation, oxidative stress, and metabolic dysregulation, all of which contribute to accelerated aging. The implications of this understanding are profound, as prediabetes emerges as a critical period in an individual's life, influencing various physiological systems, including the vascular and neural systems, metabolic functions, hormonal regulation, and bone health. Recognizing the profound influence of prediabetes on senescence provides a foundation for personalized intervention strategies to mitigate age-related complications and promote healthy aging. Future research directions call for a more diverse array of biomarkers, in-depth exploration of their roles, and the development of tailored precision medicine strategies to ensure a holistic understanding and effective management of prediabetes-induced senescence and its implications for aging. This knowledge has far-reaching implications for public health and clinical practice, emphasizing the need for early detection and intervention in prediabetic individuals to enhance the quality of life in an aging population with diverse needs.

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Resistant Starch as a Dietary Intervention to Limit the Progression of Diabetic Kidney Disease

Cited by 12 publications

References 149 publications

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

The role and mechanism of the gut microbiota in the development and treatment of diabetic kidney disease

The roles of gut microbiota and its metabolites in diabetic nephropathy

Identification of Putative Causal Relationships Between Blood-Based Biomarkers and Prediabetes-Induced Senescence: A Comprehensive Review

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