Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis

Navarro, Stephanie Dynczuki; Mauro, M O; Pesarini, João Renato; Ogo, F M; Oliveira, Rodrigo Juliano

doi:10.4238/2015.march.6.14

Cited by 19 publications

(34 citation statements)

References 29 publications

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“…Other studies also use these two parameters to prove the absence of toxicity Cantero et al, 2015;Navarro et al, 2015;Martello et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The collection of blood samples (caudal puncture) was carried out on 24 h (T1) to evaluate the (anti) genotoxicity by the comet assay and 24, 48, and 72 h, corresponding to T1, T2, and T3, respectively, to evaluate the (anti) mutagenicity using the micronucleus test. At the end of the experimentation period (12 weeks) the animals were euthanized for evaluation of (anti) carcinogenicity through the foci of aberrant crypts Pesarini et al, 2013;Navarro et al, 2015). The control group received distilled water by gavage every day until the 12th week.…”

Section: Experimental Designmentioning

confidence: 99%

“…administered twice a week for two consecutive weeks, intraperitoneally (ip) (Ishii et al, 2011;Mauro et al, 2013;Cantero et al, 2015;Navarro et al, 2015). During the use, DMH was diluted in EDTA solution (0.37 mg/mL) with the same solution used as a vehicle for the control group treatment (Ishii et al, 2011;Mauro et al, 2013;Pesarini et al, 2013;Cantero et al, 2015;Navarro et al, 2015). DMH is an indirect trigger of colorectal carcinogenesis andone of the most used drugs in experimental models (Jucá et al, 2014).…”

Section: Induction Of Colorectal Carcinogenesismentioning

confidence: 99%

“…Data concerning the total number of ACF, aberrant crypts per foci, and the relation of crypt/foci were also analyzed. Statistical analysis was done by ANOVA or the Tukey test (P < 0.05) (Ishii et al, 2011;Mauro et al, 2013;Pesarini et al, 2013;Cantero et al, 2015;Navarro et al, 2015).…”

Section: Aberrant Crypt Focus Essaymentioning

confidence: 99%

“…In contrast, high intake of fiber (prebiotics) can reduce the risk of colon cancer (Ishii et al, 2011;Pesarini et al, 2013;Mauro et al, 2013;Cantero et al, 2015;Navarro et al, 2015). Besides prebiotics and probiotics (Cui et al, 2013), the symbiotic relationship between immune cells and gut microbiota (Yamamoto and Matsumoto, 2016) in the prevention of this disease also needs to be highlighted.…”

Section: Introductionmentioning

confidence: 99%

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Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

et al. 2017

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ABSTRACT. Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia ® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa.

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“…Other studies also use these two parameters to prove the absence of toxicity Cantero et al, 2015;Navarro et al, 2015;Martello et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

Section: Induction Of Colorectal Carcinogenesismentioning

confidence: 99%

Section: Aberrant Crypt Focus Essaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

et al. 2017

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Green banana resistant starch: A promising potential as functional ingredient against certain maladies

Munir,

Alam,

Nadeem

et al. 2024

Food Science & Nutrition

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This review covers the significance of green banana resistant starch (RS), a substantial polysaccharide. The food industry has taken an interest in green banana flour due to its 30% availability of resistant starch and its approximately 70% starch content on a dry basis, making its use suitable for food formulations where starch serves as the base. A variety of processing techniques, such as heat‐moisture, autoclaving, microwaving, high hydrostatic pressure, extrusion, ultrasound, acid hydrolysis, and enzymatic debranching treatments, have made significant advancements in the preparation of resistant starch. These advancements aim to change the structure, techno‐functionality, and subsequently the physiological functions of the resistant starch. Green bananas make up the highest RS as compared to other foods and cereals. Many food processing industries and cuisines now have a positive awareness due to the functional characteristics of green bananas, such as their pasting, thermal, gelatinization, foaming, and textural characteristics. It is also found useful for controlling the rates of cancer, obesity, and diabetic disorders. Moreover, the use of GBRS as prebiotics and probiotics might be significantly proved good for gut health. This study aimed at the awareness of the composition, extraction and application of the green banana resistant starch in the future food products.

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Higher Chain Length Distribution in Debranched Type‐3 Resistant Starches (RS3) Increases TLR Signaling and Supports Dendritic Cell Cytokine Production

Lépine

Hilster

Leemhuis

et al. 2018

Molecular Nutrition Food Res

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Scope Resistant starches (RSs) are classically considered to elicit health benefits through fermentation. However, it is recently shown that RSs can also support health by direct immune interactions. Therefore, it has been hypothesized that the structural traits of RSs might impact the health benefits associated with their consumption. Methods and results Effects of crystallinity, molecular weight, and chain length distribution of RSs are determined on immune Toll‐like receptors (TLRs), dendritic cells (DCs), and T‐cell cytokines production. To this end, four type‐3 RSs (RS3) are compared, namely Paselli WFR, JD150, debranched Etenia, and Amylose fraction V, which are extracted from potatoes and enzymatically modified. Dextrose equivalent seems to be the most important feature influencing immune signaling via activation of TLRs. TLR2 and TLR4 are most strongly stimulated. Especially Paselli WFR is a potent activator of multiple receptors. Moreover, the presence of amylose, even to residual levels, enhances DC and T‐cell cytokine responses. Paselli WFR and Amylose fraction V influence T‐cell polarization. Conclusions It has been shown here that chain length and particularly dextrose equivalent are critical features for immune activation. This knowledge might lead to tailoring and design of immune‐active RS formulations.

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Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis

Cited by 19 publications

References 29 publications

Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

Green banana resistant starch: A promising potential as functional ingredient against certain maladies

Higher Chain Length Distribution in Debranched Type‐3 Resistant Starches (RS3) Increases TLR Signaling and Supports Dendritic Cell Cytokine Production

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