Resistance Training Modulates the Matrix Metalloproteinase-2 Activity in Different Trabecular Bones in Aged Rats

Neto, Ivo Vieira de Sousa; Durigan, João Luíz Quagliotti; Farias, Gonçalo Carreiro de; Bogni, Fabio Henrique; Ruivo, Amanda Lima; Araújo, Juliana Oliveira de; Nonaka, Keico Okino; Selistre-de-Araujo, Heloisa S; Marqueti, Rita de Cássia

doi:10.2147/cia.s276518

Cited by 4 publications

(3 citation statements)

References 41 publications

(71 reference statements)

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“…In bone tissue, matrix metalloproteinases (MMPs) are an important coupling factor for bone remodeling, and they play an important role in the processes of osteoblast differentiation, osteoid dissolution, and osteoclast recruitment and migration [100]. Aging [101,102] and ovariectomies (menopause) [93] both led to a decrease in MMP-2 activity in rats. Studies have shown that, after a certain period of resistance training, the activity of MMP-2 in the bone tissue of aged rats, ovariectomized rats and normal rats was significantly increased, and the positive balance of bone metabolism was promoted [93,101,102].…”

Section: Effects Of Resistance Training On Bone Metabolism In Middle-...mentioning

confidence: 99%

“…Aging [101,102] and ovariectomies (menopause) [93] both led to a decrease in MMP-2 activity in rats. Studies have shown that, after a certain period of resistance training, the activity of MMP-2 in the bone tissue of aged rats, ovariectomized rats and normal rats was significantly increased, and the positive balance of bone metabolism was promoted [93,101,102]. Dornelles's team found that the combination of resistance strength training and raloxifene (Ral) alleviated bone loss in ovariectomized rats [88] and naturally aging female rats [87] and improved the BMD and degeneration of bone microstructures.…”

Section: Effects Of Resistance Training On Bone Metabolism In Middle-...mentioning

confidence: 99%

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The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis

Gao¹,

Zhao²,

Zhao³

et al. 2023

Aging and disease

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Bone is a tissue that is active throughout the lifespan, and its physiological activities, such as growth, development, absorption, and formation, are always ongoing. All types of stimulation that occur in sports play an important role in regulating the physiological activities of bone. Here, we track the latest research progress locally and abroad, summarize the recent, relevant research results, and systematically summarize the effects of different types of exercise on bone mass, bone strength and bone metabolism. We found that different types of exercise have different effects on bone health due to their unique technical characteristics. Oxidative stress is an important mechanism mediating the exercise regulation of bone homeostasis. Excessive high-intensity exercise does not benefit bone health but induces a high level of oxidative stress in the body, which has a negative impact on bone tissue. Regular moderate exercise can improve the body's antioxidant defense ability, inhibit an excessive oxidative stress response, promote the positive balance of bone metabolism, delay age-related bone loss and deterioration of bone microstructures and have a prevention and treatment effect on osteoporosis caused by many factors. Based on the above findings, we provide evidence for the role of exercise in the prevention and treatment of bone diseases. This study provides a systematic basis for clinicians and professionals to reasonably formulate exercise prescriptions and provides exercise guidance for patients and the general public. This study also provides a reference for follow-up research.

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Section: Effects Of Resistance Training On Bone Metabolism In Middle-...mentioning

confidence: 99%

Section: Effects Of Resistance Training On Bone Metabolism In Middle-...mentioning

confidence: 99%

The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis

Gao¹,

Zhao²,

Zhao³

et al. 2023

Aging and disease

View full text Add to dashboard Cite

show abstract

“…15 The modulation of ECM functions is regulated by matrix metalloproteinases (MMPs), a family of zinc-dependent endoproteases that degrade or remodel the ECM proteins, including collagen, fibronectin, and laminin and glycoproteins. [16][17][18] The MMP-2 promotes positive effects in skeletal muscle, such as the release of local growth factors and the stimulation of angiogenesis, proliferation, 17 differentiation, and migration of satellite cells to injury sites, allowing tissue repair. 19,20 These adaptations are relevant to maintain the physiological functions and functional integrity of skeletal muscle in the setting of skeletal muscle hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

Moderate Treadmill Training Induces Limited Effects on Quadriceps Muscle Hypertrophy in Mice Exposed to Cigarette Smoke Involving Metalloproteinase 2

Ramos¹,

Neto²,

Toledo-Arruda³

et al. 2022

COPD

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Background Long-term cigarette smoke (CS) induces substantive extrapulmonary effects, including musculoskeletal system disorders. Exercise training seems to protect long-term smokers against fiber atrophy in the locomotor muscles. Nevertheless, the extracellular matrix (ECM) changes in response to aerobic training remain largely unknown. Thus, we investigated the effects of moderate treadmill training on aerobic performance, cross-sectional area (CSA), fiber distribution, and metalloproteinase 2 (MMP-2) activity on quadriceps muscle in mice exposed to chronic CS. Methods Male mice were randomized into four groups: control or smoke (6 per group) and exercise or exercise+smoke (5 per group). Animals were exposed to 12 commercially filtered cigarettes per day (0.8 mg of nicotine, 10 mg of tar, and 10 mg of CO per cigarette). The CSA, fibers distribution, and MMP-2 activity by zymography were assessed after a period of treadmill training (50% of maximal exercise capacity for 60 min/day, 5 days/week) for 24 weeks. Results The CS exposure did not change CSA compared to the control group (p>0.05), but minor fibers in the frequency distribution (<1000 µm 2 ) were observed. Long-term CS exposure attenuated CSA increases in exercise conditions (smoke+exercise vs exercise) while did not impair aerobic performance. Quadriceps CSA increased in mice nonsmoker submitted to aerobic training (p = 0.001). There was higher pro-MMP-2 activity in the smoke+exercise group when compared to the smoke group (p = 0.01). Regarding active MMP-2, the exercise showed higher values when compared to the control group (p = 0.001). Conclusion Moderate treadmill training for 24 weeks in mice exposed to CS did not modify CSA, despite inducing higher pro-MMP-2 activity in the quadriceps muscle, suggesting limited effects on ECM remodeling. Our findings may contribute to new insights into molecular mechanisms for CS conditions.

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