Resistance training increases insulin-induced vasodilation in the mesenteric artery of healthy rats

Abstract

This study evaluated the ability of resistance training (RT) of moderate intensity to promote vascular changes in insulin-induced vasodilation in healthy animals. Wistar rats were divided into two groups: control (CON) and trained (eight weeks of training, performing 3 sets with 10 repetitions at 60% of maximum intensity). Forty-eight hours after the last session of the RT, the animals were sacrifi ced and vascular reactivity to insulin in the absence and presence of LY294002 (phosphatidylinositol 3-kinase inhibitors (PI3K), L-NAME (nitric oxide synthase (NOS) inhibitors) and BQ123 (endothelin A antagonist (ET-A) receptor). In addition, phenylephrine (Phe)-induced vasoconstriction in the absence and presence of L-NAME was also evaluated. The RT group showed greater vasodilation in maximal response compared to the CON group. After PI3K inhibition, vasodilation was reduced in both groups. However, when the NOS participation was evaluated, the RT group showed contraction in relation to the CON group, which was abolished by BQ123.In addition, the RT group had an increase in nitrite levels compared to the CON group.When the Phe response was evaluated, there was a reduction in tension in the RT group compared to the CON group. The results suggest that RT improves vascular reactivity.

Carob Extract Supplementation Together with Caloric Restriction and Aerobic Training Accelerates the Recovery of Cardiometabolic Health in Mice with Metabolic Syndrome

“…Finally, our results show that the combination of CSAT+ ® supplementation and aerobic training is the only effective strategy to prevent obesity-induced vascular insulin resistance, pointing again to a synergistic effect between them. These results disagree with those reported in previous studies in which both training [ 68 ] or CSAT+ ® supplementation alone [ 18 ] increase insulin-induced vasodilation. These discrepancies could be due to differences in the species (mice vs. humans), type of exercise (aerobic vs. resistance), or to the duration of the supplementation with CSAT+ ® (two weeks vs. twenty weeks).…”