Resistance Training in Patients With Peripheral Arterial Disease: Effects on Myosin Isoforms, Fiber Type Distribution, and Capillary Supply to Skeletal Muscle

Abstract

The purpose of this study was to investigate the effects of a progressive resistance training program on myosin heavy chain isoform expression, fiber type, and capillarization in patients with symptomatic peripheral arterial disease. Patients were randomized to either a training group (n = 11, mean +/- SD, 70 +/- 6 years, 4 men, 7 women) or a control group (n = 9, 66 +/- 6 years, 5 men, 4 women). The training sessions were completed 3 times/week, using 2 sets of various exercises, each performed for 8-15 repetitions. Muscle biopsies were obtained before and after 24 weeks from the medial gastrocnemius. Following the 24-week training program, the training group had significantly decreased the percentage of myosin heavy chain type IIB. The proportion of type IIB/AB fibers as measured by using myosin adenosine triphosphatase histochemistry decreased significantly in the training group. There were significant increases in type I and type II fiber areas, and capillary density also increased significantly in the training group. There were significant increases in 10 repetition maximum leg press and calf press strengths in the trained subjects. There were no significant changes in any of the measurements in the control group. It is concluded that progressive resistance training results in significant increases in muscle strength and alters skeletal muscle composition of subjects with peripheral arterial disease.

Strength training increases walking tolerance in intermittent claudication patients: Randomized trial

“…After 12 weeks of lower body ST, improvement in initial claudication distance (ICD) 12 and total walking distance (TWD) 12,13 were observed. In addition, only one study 13 compared the effects of ST with those produced by WT, which is considered the best mode of exercise for patients with IC.…”

Creatine supplementation as a potential therapeutic aid in peripheral arterial obstructive disease rehabilitation

“…[7][8][9]16,17,30,[32][33][34] Once muscular strength could be strongly correlated with walking capacity (most accessed measure of fitness capacity) in PAOD patients by Regensteiner et al 34 and Gerdle et al 32 interventions (resistance training) to counteract this condition has been proposed 11,12 and studied with documented positive benefits. [13][14][15][16][17] Additional to resistance training, as a beneficial exercise type prescription in non diseased population, 35 association of Cr supplementation has been studied and proposed as a more effective intervention to improvements muscular strength. 36 In fact two recent meta-analysis 37,38 documented that Cr supplementation can significantly increase muscular capacity to generate strength.…”

“…[6][7][8][9] Cost-effectiveness strategies 10 to counteract muscle, nerve and metabolism impairments, and to reduce the loss of physical fitness capacity, like exercise training have been previously proposed 11,12 and studied. [13][14][15][16][17] Therefore, adding up the cost-effectiveness and the safety profile of studied benefits of Cr supplementation 18,19 and the clinical frame of PAOD, the use of Cr rises as a potential therapeutic aid to be considered.…”

Reprodutibilidade do teste de 1-RM em indivíduos com doença arterial obstrutiva periférica

“…Consequentemente, a avaliação da força muscular em indivíduos com DAOP tem sido útil para identificar os níveis de força muscular e para monitorar as alterações nessa variável ao longo de programas de intervenção (2)(3)(4)(5)(6)(7) . Além disso, em indivíduos com disfunções ortopédicas limitantes para a caminhada, como os amputados, e em indivíduos que apresentam a doença nos dois membros inferiores, o teste de força tem sido indicado por fornecer indicativo da força muscular em cada membro individualmente.…”