Resistance training exercise and creatine in patients with Charcot–Marie–Tooth disease

Abstract

Resistance exercise and creatine supplementation independently improve strength and function in patients with certain neuromuscular diseases. The purpose of this study was to examine the effects of resistance training with and without creatine supplementation on muscle, strength, and function in patients with Charcot-Marie-Tooth (CMT) disease. Twenty patients with CMT consumed 5 g/day creatine or placebo while participating in resistance training for 12 weeks. Energy metabolites, muscle fiber type and size, strength, and timed activities of daily living were measured before and after training. There were no differences between creatine or placebo groups for any outcome. For the groups combined, exercise training increased type I muscle fiber diameter (48.2 +/- 14.2 microm vs. 55.4 +/- 14.8 microm), strength, and activities of daily living (ADL) times. Thus, patients respond to resistance training with muscle fiber adaptations, and improvements in strength and function. Creatine was not beneficial.

Anabolic Effect of Exercise Training in People with End-Stage Renal Disease on Hemodialysis: A Systematic Review with Meta-analysis

“…Since neuropathic and myopathic changes have been reported in the skeletal muscle of people with ESRD on HD, 5 unequal proportions of participants with neuropathies in the different groups may have influenced the outcomes. 32 However, the included studies did not report the incidence of polyneuropathy among participants. Further, Cupisti and colleagues 33 reported a positive relationship between the mean daily metabolic equivalent of tasks and the phase angle measured using bio-electrical impedance vector analysis, a proxy measure for muscle mass and, hence, for strength.…”

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation

“…These observations are consistent with the results from an in vivo study showing an increase in the protein content of the myogenic transcription factors myogenic regulatory factor-4 (MRF4) and myogenin after recovery from cast-induced atrophy in the skeletal muscle of young subjects supplemented with CrM (36). Also, CrM supplementation in conjunction with strength exercise training increases satellite cell number, myonuclei concentration (63), and type II muscle fiber area (94).Given the emerging interest in CrM supplementation in the management of neuromuscular disorders, including amyotrophic lateral sclerosis (44), Huntington's disease (56), Parkinson's disease (55), Alzheimer's disease (9), and muscular dystrophies (13,85,87,88), our aim was to elucidate potential cellular and molecular mechanisms that underlie its therapeutic efficacy. The objectives of this study were 1) to examine the intracellular global gene expression in human skeletal muscle following 10 days of CrM supplementation using cDNA microarray analysis, and 2) to evaluate the effect of short-term CrM supplementation on targeted mRNA expression and proArticle published online before print.…”

“…Given the emerging interest in CrM supplementation in the management of neuromuscular disorders, including amyotrophic lateral sclerosis (44), Huntington's disease (56), Parkinson's disease (55), Alzheimer's disease (9), and muscular dystrophies (13,85,87,88), our aim was to elucidate potential cellular and molecular mechanisms that underlie its therapeutic efficacy. The objectives of this study were 1) to examine the intracellular global gene expression in human skeletal muscle following 10 days of CrM supplementation using cDNA microarray analysis, and 2) to evaluate the effect of short-term CrM supplementation on targeted mRNA expression and proArticle published online before print.…”

Irradiação contralateral de força para a ativação do músculo tibial anterior em portadores da doença de Charcot-Marie-Tooth: efeitos de um programa de intervenção por FNP

“…The disease is an autosomal dominant demyelinating polyneuropathy associated with a DNA duplication of chromosome 17 [3][4][5][6] . CMT-1A produces typical functional changes, such as reduction in the conduction speed of the peripheral nerve [7][8][9][10] , hypo-or areflexia, sensitivity loss, distal muscle atrophy and subsequent progressive functional disability, which accompanies the evolution of the disease [11][12][13] . The lower limbs (LL) of patients with CMT are the most affected, and one of the characteristic changes is foot drop, which is a result of a muscular atrophy of variable severity.…”

“…Muscle biopsies of patients with CMT-1A submitted to a 12-week strengthening protocol showed that, with an adequate protocol, there will be muscular adaptation to strength training 12 . Aitkens et al 16 and Kilmer et al 17 demonstrated that lowand moderate-intensity strengthening protocols (with weights on the fist and ankle, 12 weeks of treatment with three weeks in submaximal regime) in patients with neuromuscular diseases, including CMT-1A, improve upper and lower limb muscle strength 16 .…”