Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12‐Month Randomized Controlled Trial

Bolandzadeh, Niousha; Tam, Roger; Handy, Todd C.; Nagamatsu, Lindsay S.; Hsu, Chun Liang; Davis, Jennifer C.; Dao, Elizabeth; Beattie, B. Lynn; Liu-Ambrose, Teresa

doi:10.1111/jgs.13644

Cited by 82 publications

(67 citation statements)

References 51 publications

(113 reference statements)

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“…Briefly, WMLs were identified and digitally marked (i.e., placing seed points) by a radiologist on T2 and PD weighted images. Marked WMLs were automatically segmented by a customized Parzen windows classifier that estimated the intensity distribution of the lesions – which also included heuristics that optimized the accuracy of the estimated distributions (Parzen, 1962; McAusland et al, 2010; Bolandzadeh et al, 2015). WML segmentation was reviewed by a trained technician to ensure accuracy.…”

Section: Methodsmentioning

confidence: 99%

“…Despite the growing recognition that targeted exercise training may promote mobility outcomes in older adults via central mechanisms (Liu-Ambrose et al, 2013), few intervention studies of exercise to date have provided direct evidence for this theory (Bolandzadeh et al, 2015). A better understanding of the neural mechanisms underlying exercise-induced improvements in mobility may facilitate the development and refinement of preventative/intervention strategies, as well as identify the populations for whom these effects apply.…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

Hsu

Best

Wang

et al. 2017

Front. Hum. Neurosci.

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Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)—and exercise-induced changes in FPN connectivity would correlate with changes in mobility. We focused on the FPN as it is involved in top-down attentional control as well as motor planning and motor execution. Participants were randomized either to usual-care (CON), which included monthly educational materials about VCI and healthy diet; or thrice-weekly aerobic training (AT), which was walking outdoors with progressive intensity. Functional magnetic resonance imaging was acquired at baseline and trial completion, where the participants were instructed to perform bilateral finger tapping task. At trial completion, compared with AT, CON showed significantly increased FPN connectivity strength during right finger tapping (p < 0.05). Across the participants, reduced FPN connectivity was associated with greater cardiovascular capacity (p = 0.05). In the AT group, reduced FPN connectivity was significantly associated with improved mobility performance, as measured by the Timed-Up-and-Go test (r = 0.67, p = 0.02). These results suggest progressive AT may improve mobility in older adults with SIVCI via maintaining intra-network connectivity of the FPN.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

Hsu

Best

Wang

et al. 2017

Front. Hum. Neurosci.

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“…The Dance intervention might have increased the volume of the fornix, leading to decreased partial volume and decreased RD and MD. Local increases in WM volume and macrostructural integrity have been observed as a result of lifestyle interventions with physical activity (Colcombe et al, 2006; Bolandzadeh et al, 2015). In sum, we speculate that the observed increase in FA results from both macro- and micro-structural reorganization of the fornix.…”

Section: Discussionmentioning

confidence: 99%

White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults

Burzyńska

Jiao

Knecht

et al. 2017

Front. Aging Neurosci.

115

110

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Degeneration of cerebral white matter (WM), or structural disconnection, is one of the major neural mechanisms driving age-related decline in cognitive functions, such as processing speed. Past cross-sectional studies have demonstrated beneficial effects of greater cardiorespiratory fitness, physical activity, cognitive training, social engagement, and nutrition on cognitive functioning and brain health in aging. Here, we collected diffusion magnetic resonance (MRI) imaging data from 174 older (age 60–79) adults to study the effects of 6-months lifestyle interventions on WM integrity. Healthy but low-active participants were randomized into Dance, Walking, Walking + Nutrition, and Active Control (stretching and toning) intervention groups (NCT01472744 on ClinicalTrials.gov). Only in the fornix there was a time × intervention group interaction of change in WM integrity: integrity declined over 6 months in all groups but increased in the Dance group. Integrity in the fornix at baseline was associated with better processing speed, however, change in fornix integrity did not correlate with change in processing speed. Next, we observed a decline in WM integrity across the majority of brain regions in all participants, regardless of the intervention group. This suggests that the aging of the brain is detectable on the scale of 6-months, which highlights the urgency of finding effective interventions to slow down this process. Magnitude of WM decline increased with age and decline in prefrontal WM was of lesser magnitude in older adults spending less time sedentary and more engaging in moderate-to-vigorous physical activity. In addition, our findings support the anterior-to-posterior gradient of greater-to-lesser decline, but only in the in the corpus callosum. Together, our findings suggest that combining physical, cognitive, and social engagement (dance) may help maintain or improve WM health and more physically active lifestyle is associated with slower WM decline. This study emphasizes the importance of a physically active and socially engaging lifestyle among aging adults.

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“…A cross-sectional study found that moderate to vigorous levels of physical activity was associated with lower WMH volume in healthy older adults (Burzynska et al 2014). An RCT in community dwelling older women reported that resistance training reduced WMH progression over 12 months (Bolandzadeh et al 2015). These results are supported by the SMART Trial, an RCT conducted in people with MCI.…”

Section: Role Of Exercise In Mitigating Sivcimentioning

confidence: 81%

“…Epidemiological studies have identified several potential modifiable risk and protective factors that could be targeted in dementia prevention. For example, factors that may increase the risk for cognitive decline include: history of depression, sleep disturbances, smoking, traumatic brain injury, mid-life obesity, hyperlipidemia, diabetes, and (Bolandzadeh et al 2015;Suo et al 2016) and increase white matter intergrity (Voss et al 2013b); (iii) Exercise may protect the cerebrovasculature by inducing the shear stress required to increase cerebral blood flow by increasing the bioavailability of nitric oxide and delaying arterial stiffening (Bolduc et al 2013). Proper endothelial function is also important for the health of oligodendrocytes and the regenerative capacity of cerebral white matter (Rajani and Williams 2017) and; (iv) Vascular risk factors such as hypertension, diabetes mellitus, and hypercholesteremia are associated with SIVCI and endothelial dysfunction.…”

Section: Resultsmentioning

confidence: 99%

The role of exercise in mitigating subcortical ischemic vascular cognitive impairment

Dao

Hsiung

Liu-Ambrose

2017

Journal of Neurochemistry

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Subcortical ischemic vascular cognitive impairment (SIVCI) is the most preventable form of cognitive dysfunction. There is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI. Currently, there are no curative pharmaceutical treatments for vascular dementia; however, exercise may be a promising strategy to combat SIVCI. This review will focus on the role of exercise as a strategy to prevent or slow the progression of SIVCI, with particular emphasis on the mechanisms by which exercise may improve cerebrovascular function. We propose that exercise may be an effective strategy to combat SIVCI by improving cognitive function, increasing the bioavailability of neurotrophins, stimulating endothelial function, and controlling vascular risk factors. Keywords: endothelial function, exercise, subcortical ischemic vascular cognitive impairment, white matter hyperintensities. J. Neurochem. (2018) 144, 582--594.This article is part of the Special Issue "Vascular Dementia".The World Health Organization estimates that 47.5 million people worldwide are living with dementia with an expected increase of 7.7 million new cases each year (World Health Organization 2012). Dementia is a common cause of disability and dependency among older adults; thus, the high prevalence and incidence of dementia is a great burden to health, social, and financial systems (World Health Organization 2012). Vascular cognitive impairment (VCI) is the second leading cause of cognitive impairment and dementia (van Norden et al. 2012). Vascular cognitive impairment is an umbrella term that encompasses the full spectrum of cognitive and functional impairments associated with cerebrovascular disease, from frank dementia to mild cognitive deficits (Gorelick et al. 2011). Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of VCI and is caused by cerebral small vessel disease (SVD) (Moorhouse and Rockwood 2008). Cerebral SVD is caused by chronic and diffuse ischemia and is most often associated with damage to cerebral white matter. Specifically, it manifests as white matter hyperintensities (WMH), lacunes, enlarged perivascular spaces, and microbleeds (Wardlaw et al. 2013b).Overall, there is converging evidence from animal and human studies that indicate vascular injury as the primary cause of SIVCI (Iadecola 2013). Vascular risk factors such as Received May 29, 2017; revised manuscript received August 9, 2017; accepted August 11, 2017.Address correspondence and reprint requests to Teresa Liu-Ambrose, University of British Columbia, Djavad Mowafaghian Centre for Brain Health, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z3. USA. E-mail: teresa.ambrose@ubc.caAbbreviations used: ADAS-Cog, Alzheimer's Disease Assessment Scale-cognitive subscale; BDNF, brain-derived neurotrophic factor; CBF, cerebral blood flow; eNOS, endothelial nitric oxide synthase; fMRI, functional magnetic resonance imaging MRI; IGF-1, insulin-like growth factor 1; MCI, mild cognitive impairment; MRI, m...

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Resistance Training and White Matter Lesion Progression in Older Women: Exploratory Analysis of a 12‐Month Randomized Controlled Trial

Abstract: Engaging in progressive RT may reduce WML progression.

Cited by 82 publications

References 51 publications

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults

The role of exercise in mitigating subcortical ischemic vascular cognitive impairment

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