Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell‐specific fibroblast growth factor 1 transgene

Abstract

Overdevelopment of visceral adipose is positively correlated with the etiology of obesity‐associated pathologies including cardiovascular disease and insulin resistance. However, identification of genetic, molecular, and physiological factors regulating adipose development and function in response to nutritional stress is incomplete. Fibroblast Growth Factor 1 ( FGF 1) is a cytokine expressed and released by both adipocytes and endothelial cells under hypoxia, thermal, and oxidative stress. Expression of Fibroblast Growth Factor 1 ( FGF 1) in adipose is required for normal depot development and remodeling. Loss of FGF 1 leads to deleterious changes in adipose morphology, metabolism, and insulin resistance. Conversely, diabetic and obese mice injected with recombinant FGF 1 display improvements in insulin sensitivity and a reduction in adiposity. We report in this novel, in vivo study that transgenic mice expressing an endothelial‐specific FGF 1 transgene ( FGF 1‐Tek) are resistant to high‐fat diet‐induced abdominal adipose accretion and are more glucose‐tolerant than wild‐type control animals. Metabolic chamber analyses indicate that suppression of the development of visceral adiposity and insulin resistance was not associated with alterations in appetite or resting metabolic rate in the FGF 1‐Tek strain. Instead, FGF 1‐Tek mice display increased locomotor activity that likely promotes the utilization of dietary fatty acids before they can accumulate in adipose and liver. This study provides insight into the impact that genetic differences dictating the production of FGF 1 has on the risk for developing obesity‐related metabolic disease in response to nutritional stress.

Potential Anticarcinogenic Effects From Plasma of Older Adults After Exercise Training: An Exploratory Study

“…FGF-1, also called acidic FGF, plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation, and migration ( Li, 2018 ). Interestingly, experimental studies show that mice treated with FGF-1 restore blood glucose levels and endothelial functions, highlighting the role of this growth factor in vascular health and metabolic control ( Keeley et al, 2019 ). Furthermore, the mutated fgf1 gene is linked to an accelerated neurological senescence profile in mice ( Carter et al, 2005 ).…”

Selection of both habitat and genes in specialized and endangered caribou

“…We subsequently ran RSFs at the individual level in a multivariate logistic regression framework with the glm function in R 3.5. When the p-value for a specific β was ≥0.05, the value of β was manually changed to zero, as this value indicates that a resource is used in proportion to its availability (indifferent choice of an animal for a specific resource; Leclerc et al, 2016). Our study assessed selection of resources present within individual ranges each season.…”