Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression

Шишкина, Г. Т.; Kalinina, Tatyana; Berezova, I. V.; Булыгина, В. В.; Дыгало, Н. Н.

doi:10.1016/j.bbr.2010.05.003

Cited by 54 publications

(42 citation statements)

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“…Como se mencionó anteriormente, se han realizado algunas investigaciones sobre diferencias individuales usando como endofenotipo de interés la inmovilidad en la PNF (Weiss, Cierpial, & West, 1998;Taghzouti, Lamarque, Kharouby & Simon, 1999;Naudon & Jay 2005;Shishkina et al, 2010). De esta manera, mediante la comparación de animales con baja inmovilidad (i.e., animales que presentan niveles reducidos de la conducta relacionada con la depresión) con animales con alta inmovilidad (i.e., animales con mayores niveles de la conducta relacionada con la depresión) (Fig.…”

Section: Diferencias Individuales En Conductas Relacionadas Con La Deunclassified

“…Desde una perspectiva molecular, Shishkina et al (2010) lograron identificar diferencias en cuanto a los niveles de proteínas específicas relacionadas con el efecto del estrés agudo a nivel hipocampal. Los resultados anteriores permiten caracterizar las diferencias entre animales con alta y baja inmovilidad lo que en última instancia, permitiría no sólo entender mejor los mecanismos relacionados con la depresión sino al mismo tiempo, empezar a comprender por qué algunos individuos son más propensos que otros a desarrollar conductas depresivas como consecuencia del estrés.…”

Section: Diferencias Individuales En Conductas Relacionadas Con La Deunclassified

“…Lo anterior adquiere importancia cuando el endofenotipo escogido se relaciona con una condición o con una patología cuya base biológica se quiere dilucidar, además de que también permite identificar factores de susceptibilidad o de resistencia a ella (Shishkina, Kalinina, Berezova, Bulygina & Dygalo, 2010). Aunque este enfoque puede ser utilizado en estudios con humanos, buena parte del trabajo realizado hasta hoy se ha llevado a cabo usando modelos animales; estos modelos han sido desarrollados principalmente para el estudio de la ansiedad y en menor grado, de la depresión (revisado en Armario & Nadal, 2013).…”

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Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

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2014

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Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresiónResumen. El estudio de las diferencias individuales en la prueba de nado forzado (PNF) en ratas permite la identificación de factores de susceptibilidad o de resistencia en el desarrollo conductas relacionadas con la depresión. Para estudiar estas diferencias, varios grupos de ratas fueron sometidos a la PNF; posteriormente, los animales con baja y alta inmovilidad fueron comparados, lo que permitió identificar una serie de características que podrían estar actuando como factores de riesgo o de protección. Así, factores neurobiológicos como la expresión diferencial en el núcleo accumbens del receptor 1 para el factor liberador de corticotropina (CRFR1), una tasa diferencial de recambio de dopamina en esa misma región y la cinética de expresión diferencial del factor neurotrófico derivado del cerebro (BDNF) en la corteza prefrontal, podrían jugar un papel importante en la modulación de conductas depresivas. La presente revisión resume nuestros resultados más importantes en esta línea de investigación.Palabras clave. Diferencias individuales, prueba de nado forzado, conducta, expresión génica, cerebro.Abstract. The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression-related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line.Keywords. Individual differences, forced swimming test, behavior, gene expression, brain.Actualidades en Psicología, 28(117), 2014, 53-66 ISSN 2215 Individual differences in animal models: an approach to study neurobiological factors related to depression

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Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

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“…Apoptosis plays an important role in the pathogenesis of neurodegenerative diseases [14]. Studies also showed, that in acute and chronic stress, activation of intrinsic mitochondrial pathway due to stress and subsequent morphological variations results in atrophy in different areas of brain, especially in hippocampus [15] [16]. The B-cell lymphoma 2 (Bcl-2) family members play an important role in the controlling of apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Association of Bax and Bcl-2 Functional Polymorphisms and Protein Levels with Posttraumatic Stress Disorder

Avetyan¹,

Arakelyan²,

Mkrtchyan³

2018

JBM

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Background: Posttraumatic stress disorder (PTSD) is an anxiety disease influenced by both environmental and genetic factors, which affects a patient's quality of life and social stability. Recent studies have shown that the pathogenesis of PTSD is associated with apoptosis; however, the molecular mechanisms that cause such damage are not well-understood. Also it is unclear whether these pathologic alterations are genetically determined or caused by other factors. The aim of this study was to investigate the genetic association of functional polymorphisms in genes coding for apoptosis-related Bcl-2 and Bax proteins with PTSD as well as proteins levels in the blood of affected subjects. Methods: The study groups consisted of 200 combat veterans with PTSD and an equal number of healthy subjects with no family-or past-history of any psychiatric disorders. Bax and Bcl-2 proteins levels in blood were measured by ELISA. DNA samples were genotyped for SNPs using PCR-SSP. Results: According to our results, PTSD patients are characterized by increased levels of apoptotic proteins and the imbalance in the Bax/Bcl-2 ratio compared to healthy subjects. Our results also demonstrate that rs956572*A minor allele of the BCL2 gene was overrepresented in patients with PTSD compared to healthy subjects. Conclusions: The results implicate Bcl-2 and Bax in pathogenesis of PTSD on genetic and protein levels, though further studies on enlarged cohort and in different populations are required.

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“…Five weeks after the end of the stress exposure, resilient animals, in comparison to vulnerable mice, recovered faster from stress induced by an unstable hierarchy (lower corticosterone levels). Alongside this, Shishkina et al [18] tested whether rats are resilient to the development of depression-like behavior in the forced swim test (FST). Forty percent of the animals showed resilience concomitant with anti-apoptotic B cell lymphoma like X (Bcl-xl) to pro-apoptotic Bcl2-associated X (Bax) ratios in the hippocampus, a brain region known to play a critical role in emotional (dys)regulation.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Prenatal Stress in Female 5-Htt-Deficient Mice: Towards Molecular Mechanisms of Resilience

Jakob

Schraut²,

Schmitt³

et al. 2014

Dev Neurosci

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Prenatal stress (PS) exposure is known to increase the risk of developing emotional disorders like major depression in later life. However, some individuals do not succumb to adversity following developmental stress exposure, a phenomenon referred to as resilience. To date, the molecular mechanisms explaining why some subjects are vulnerable and others more resilient to PS are far from understood. Recently, we have shown that the serotonin transporter (5-HTT) gene may play a modulating role in rendering individuals susceptible or resilient to PS. However, it is not clear which molecular players are mediating the interaction between PS and the 5-Htt genotype in the context of vulnerability and resilience to PS. For this purpose, we performed a microarray study with the help of Affymetrix GeneChip® Mouse Genome 430 2.0 Array, in which we separated wild-type and heterozygous 5-Htt-deficient (5-Htt+/-) PS offspring into susceptible and resilient offspring according to their performance in the forced swim test. Performance-oriented LIMMA analysis on the mRNA expression microarray data was followed by subsequent Spearman's correlation analysis linking the individual qRT-PCR mRNA expression data to various anxiety- and depression-related behavioral and neuroendocrine measures. Results indicate that, amongst others, Fos-induced growth factor (Figf), galanin receptor 3 (Galr3), growth hormone (Gh) and prolactin (Prl) were differentially expressed specifically in resilient offspring when compared to controls, and that the hippocampal expression of these genes showed several strong correlations with various measures of the hypothalamus-pituitary-adrenal axis (re)activity. In conclusion, there seems to be an intricate interplay between the expression of Figf, Galr3, Gh and Prl and neuroendocrine regulation, which may be critical in mediating resilience to PS exposure. More insight into the exact role of these molecular players may significantly enhance the development of new treatment strategies for stress-related emotional disorders.

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Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression

Cited by 54 publications

References 63 publications

Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

Association of Bax and Bcl-2 Functional Polymorphisms and Protein Levels with Posttraumatic Stress Disorder

Differential Effects of Prenatal Stress in Female 5-Htt-Deficient Mice: Towards Molecular Mechanisms of Resilience

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