Resistance to macrolides in Group A streptococci from the European section of Turkey: genetic and phenotypic characterization

The aims of this study were to determine the susceptibilities to macrolide and tetracycline antibiotics and emm type distribution of Streptococcus pyogenes strains isolated in the Kocaeli University Hospital, Turkey. A total of 127 S. pyogenes clinical isolates were tested. Eleven (9%) isolates were resistant to erythromycin, and 23 (18%) isolates were resistant to tetracycline. Ten of the erythromycin-resistant isolates were also resistant to tetracycline. By the triple-disk test, all erythromycin-resistant isolates showed the inducible macrolide-lincosamidestreptogramin-C phenotype and harbored erm(TR) gene. tet(O) was the most common tetracycline resistance gene. Among erythromycin-tetracycline coresistant isolates, seven harbored the tet(O) gene. emm 4, emm 1, emm 2,114, and emm 89 were the most common emm types. These isolates were more susceptible to erythromycin. There was considerable emm type heterogeneity in macrolide or tetracycline resistant isolates. According to our knowledge, this is the first study in which emm type distribution is investigated in Turkey. More comprehensive studies are needed to obtain true information about the epidemiology of macrolide and tetracycline resistance and emm type distribution in Turkey.

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“…2 Moreover, all resistant isolates had lowlevel resistance to erythromycin (MIC ranges: 0.75-1 mg/ml) in the present study.…”

Section: Discussionsupporting

confidence: 51%

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Dündar

Sayan

Tamer

2010

Microbial Drug Resistance

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“…Complete characterisation of isolates is expensive and time consuming [2] and consequently the information available on erythromycin-resistant S. pyogenes clones circulating in Europe is mainly limited to the ermB and mef genes [13][14][15][16]. This study focuses on investigation of S. pyogenes isolates showing resistance to erythromycin mediated by the ermA gene.…”

Section: Introductionmentioning

confidence: 99%

Characterisation of the main clones of Streptococcus pyogenes carrying the ermA (subclass TR) gene in Spain

Montes

Orden

Tamayo

et al. 2006

International Journal of Antimicrobial Agents

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“…In Iran, 0.2% of isolates were resistant to ERY and 42% were resistant to TET [26]. In Turkey, ERY resistance was observed in 2.7% of isolates (this low rate being ascribed to the limited use of ERY, especially for streptococcal pharyngitis), whilst 22.7% were resistant to TET [42]. Although TET resistance in other bacteria has been studied extensively [43], less is known about the resistance mechanism in GAS [5,[17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Macrolide, lincosamide and tetracycline susceptibility and emm characterisation of invasive Streptococcus pyogenes isolates in Israel

Nir-Paz¹,

Block²,

Shasha³

et al. 2006

International Journal of Antimicrobial Agents

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Resistance to macrolides in Group A streptococci from the European section of Turkey: genetic and phenotypic characterization

Cited by 6 publications

References 13 publications

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Macrolide and Tetracycline Resistance andemmType Distribution ofStreptococcus pyogenesIsolates Recovered from Turkish Patients

Characterisation of the main clones of Streptococcus pyogenes carrying the ermA (subclass TR) gene in Spain

Macrolide, lincosamide and tetracycline susceptibility and emm characterisation of invasive Streptococcus pyogenes isolates in Israel

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