Resistance to insulin-stimulated-glucose uptake in patients with hypertension

Shen, Dongli; Shieh, Shyh‐Ming; Fuh, Martin Mao-Tsu; Wu, Donghai; Chen, Y; Reaven, Gerald; Chu, P

doi:10.1016/0168-8227(87)90082-9

Cited by 58 publications

(83 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Independent of body mass index or body fat distribution, patients with essential hypertension, when compared with healthy normotensive controls, have higher fasting and postprandial insulin levels, and greater reductions in insulin sensitivity [19]. This indicates that there exists a direct correlation between blood pressure and plasma insulin levels [20]. Furthermore, this raises the possibility of a role for insulin in the pathogenesis of essential hypertension.…”

Section: Hypertensionmentioning

confidence: 97%

Cardiometabolic syndrome: Pathophysiology and treatment

Castro

El‐Atat

McFarlane

et al. 2003

Current Science Inc

131

View full text Add to dashboard Cite

The cardiometabolic syndrome, an interesting constellation of maladaptive cardiovascular, renal, metabolic, prothrombotic, and inflammatory abnormalities, is now recognized as a disease entity by the American Society of Endocrinology, National Cholesterol Education Program, and World Health Organization, among others. These cardiovascular and metabolic derangements individually and interdependently lead to a substantial increase in cardiovascular disease (CVD) morbidity and mortality, making the cardiometabolic syndrome an established and strong risk factor for premature and severe CVD and stroke. Established and evolving treatment strategies including moderate physical activity, weight reduction, rigorous blood pressure control, correction of dyslipidemia, and glycemic control have proven beneficial in reversing these abnormal responses and decreasing the CVD risk.

show abstract

Section: Hypertensionmentioning

confidence: 97%

Cardiometabolic syndrome: Pathophysiology and treatment

Castro

El‐Atat

McFarlane

et al. 2003

Current Science Inc

131

View full text Add to dashboard Cite

show abstract

“…Indeed, as first shown by Shen et al [5], hypertension alone is commonly associated with insulin resistance. This association is important, as recently reported by the NHANES data, indicating that the metabolic syndrome was associated with a greater than 2.5-fold increase in the risk for chronic kidney disease and slightly less than a twofold increase in the risk for microalbuminuria [6].…”

Section: Hypertension Prevalencementioning

confidence: 86%

Hypertension management in patients with diabetic nephropathy

McCall

2004

Current Science Inc

View full text Add to dashboard Cite

Treatment of hypertension, to reverse and delay proteinuria progression and kidney failure, is the primary focus of medical management in patients with diabetic nephropathy. The initial choice for hypertension treatment in those with early nephropathy involves agents that block the renin-angiotensin system. However, it is not clear what the best choices for further drug therapy management are, because there are few data concerning the impact that antihypertensive drug combinations have on hard clinical outcomes, such as preventing the need for dialysis, and death. Patients usually require several drugs for controlling hypertension, which becomes harder to control as nephropathy progresses. In this review, it is suggested that quantitatively tracking proteinuria to guide therapy and a broad focus on the cardiovascular and renal end points are important for best outcomes in patients. Strategies may vary based on stage of disease, comorbidities, and age. Therapies not directed specifically at hypertension may also significantly aid hypertension management in prevention of progressive nephropathy, comorbidities, and mortality.

show abstract

“…The insulin-resistant state in hypertension is a timehonored notion [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Quantification of insulin sensitivity by well-accepted techniques, such as the euglycemichyperinsulinemic clamp and the minimal model analysis of FSIGTT data, in groups of nonobese and nondiabetic hypertensive patients, compared with groups of control subjects matched for age and BMI, showed significant reductions in hypertension ranging from 26% to 70% [1,7,8,14].…”

Section: Discussionmentioning

confidence: 99%

“…Knowledge of the etiology of insulin resistance and its link with hypertension, however, is far from complete [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. An improvement of knowledge can be determined by clinical applications of methods that allow quantification of indexes of insulin sensitivity in hypertensive patients to be compared with normotensive subjects.…”

Section: Introductionmentioning

confidence: 99%