“…(2014)). However, various genetic control measures have been shown to be limited by the potential generation of mutation or resistance (Alphey, Bonsall, Alphey, 2011, Watkinson-Powell, Alphey, 2017, Hammond, Kyrou, Bruttini, North, Galizi, Karlsson, Kranjc, Carpi, D’Aurizio, Crisanti, Nolan, 2017, Unckless, Clark, Messer, 2017, Champer, Reeves, Oh, Liu, Liu, Clark, Messer, 2017b, Champer, Liu, Oh, Reeves, Luthra, Oakes, Clark, Messer, 2017a) the dissociation of gene drive components (e.g. Marshall (2008)) and loss-of function mutation similar to the type studied here (Beaghton et al., 2017).…”