Resistance to fenbendazole in Ascaridia dissimilis, an important nematode parasite of turkeys

Collins, James B.; Jordan, Brian J.; Baldwin, Luke; Hebron, Claude; Paras, Kelsey L.; Vidyashankar, Anand N.; Kaplan, Ray M.

doi:10.3382/ps/pez379

Cited by 31 publications

(30 citation statements)

References 12 publications

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“…may have far-reaching consequences for the poultry industry in terms of both animal welfare and economic impact. Given the results of our study along with the former finding of the suboptimal efficacy of fenbendazole in A. dissimilis [21], it seems that resistance can be expected in the helminth parasites of poultry. Subsequently, more extensively scaled surveys of resistance are needed to determine the prevalence of anthelmintic resistance in the poultry industry.…”

Section: Discussionsupporting

confidence: 50%

“…The results of our study revealed that fenbendazole and levamisole were effective in eliminating A. galli. It should be noted that evidence of fenbendazole resistance in A. dissimilis, a closely related ascarid of chickens, has been recently reported in turkeys with a history of heavy administration of frequent intervals of fenbendazole [21].…”

Section: Discussionmentioning

confidence: 99%

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Anthelmintic efficacy of fenbendazole and levamisole in native fowl in northern Iran

2021

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Background With the increasing number of free-range domestic chickens, helminth parasites have potentially become more of a threat to commercial flocks in recent years, and routine poultry deworming is needed to improve the efficiency of chicken production. The present study deals with a field trial to study the efficacy of two generally used anthelmintics, fenbendazole and levamisole, against gastrointestinal nematodes of domestic chickens in northern Iran. Methods Of 45 domestic chicken flocks involved in the study, 20 flocks were selected to participate in fecal egg count reduction testing based on flock size from April 2017 to September 2018. The infected chickens were randomly divided into three equal groups of 30 each. Ninety chickens in the infected groups received one of the following treatments (d 0 of treatment): Group 1: 5 mg kg−1 body weight (BW) fenbendazole for 3 consecutive days; Group 2: 16 mg kg−1 BW levamisole; Group 3 control: placebo, water + DMSO (dimethylsulfoxide). The efficacy of the treatments was evaluated by comparing fecal egg counts in the treated and control groups. Results Examination of three flocks of chickens from the control group showed that 95.0% of the animals were infected with gastrointestinal nematodes with an average geometric value of 361 eggs per gram of feces. Fenbendazole at a dose of 5 mg kg−1 BW for 3 days showed an efficacy of 83.7% (P ≥ 0.05), and levamisole at a dose of 16 mg kg−1 BW showed 71.8% efficacy (P ≥ 0.05) with geometric mean eggs in a gram of feces of 100 and 199.6, respectively. In general, fenbendazole and levamisole treatment led to significantly lower activity. The result of this study revealed that fenbendazole was a better and more effective dewormer than levamisole on the three Iranian domestic chicken flocks, but the difference was not significant. Capillaria spp. were the most generally resistant nematodes followed by Trichostrongylus spp. and Amidostomum anseris. Conclusion Our results indicated that fenbendazole and levamisole effectively reduced the number of nemathodes in three Iranian domestic chicken flocks. Given the results of our study, resistance can be expected in the parasitic helminths of poultry. Additional larger scale studies are required to determine the prevalence of anthelmintic resistance in the poultry industry.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Anthelmintic efficacy of fenbendazole and levamisole in native fowl in northern Iran

2021

View full text Add to dashboard Cite

show abstract

“…may have far-reaching consequences for the poultry industry, both in terms of animal welfare and economic impact. Given the results of our study along with the former nding of the suboptimal e cacy of fenbendazole in A. dissimilis [22], it seems likely that resistance may be expected in the helminth parasite of poultry. Subsequently, more extensive scale surveys for resistance are needed to determine the prevalence of anthelminthic resistance in the poultry industry.…”

Section: Discussionmentioning

confidence: 69%

“…The results of our study revealed that fenbendazole and levamisole were most successful in eliminating A. galli. It should be noted that evidence of fenbendazole resistance in A. dissimilis, a closely related ascarid of chickens, has been recently reported in turkey with a history of the heavy administration of frequent intervals of fenbendazole [22].…”

Section: Discussionmentioning

confidence: 99%

Anthelminthic Efficacy of Fenbendazole and Levamisole in Native Fowl in Northern Iran

Soudkolaei

Kalidari

Borji

2020

Preprint

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Background: With the number of free-range domestic chickens increasing, helminth parasites have potentially become more of a threat in commercial flocks in recent years, and routine poultry worming is needed to improve chicken products. The present study deals with a field trial to study the efficiency of two generally used anthelmintics as fenbendazole and levamisole, against gastrointestinal nematodes of domestic chickens in the north of Iran. Methods: Out of 45 domestic chickens flocks that agreed to the study, 20 flocks were selected to participate in fecal egg count reduction testing based on flock size from April 2017 to September 2018. The infected chickens were randomly distributed into three equal groups of each (n = 30). Ninety chickens in the infected groups received one of the following treatments (d 0 of treatment): Group 1: 5 mg kg−1 body weight (BW) of fenbendazole for three continuous days, Group 2: 16 mg kg−1 BW of Levamisole, and Group 3: placebo; water + DMSO (the control). The efficiency of the treatments was evaluated by comparing fecal egg count in the treated groups and control group.Results: Examination of 3 herds of chickens from the control group showed that the animals were infected with gastrointestinal nematodes by 95.0% with an average geometric value of 361 eggs per gram of feces. The substance fenbendazole at a dose of 5 mg/kg b/w for three days against gastrointestinal nematodes showed an efficiency of 83.7% (P ≥0.05), and the substance levamisole at a dose of 16 mg/kg b/w showed 71.8% (P ≥0.05) with geometric mean eggs in a gram of feces 100 and 199.6, respectively. In general, the initial substances of fenbendazole and leamisole showed significantly lower activity.. The result of this study revealed that fenbendazole was a better effective dewormer than levamisole on the three Iranian domestic chicken flocks, but it is not significant. Capillaria spp., were the most generally resistant nematodes followed by Trichostrongylus spp., and Amidostomum anseris.Conclusion: Our results indicated there is a reduction efficacy in fenbendazole and levamisole in three Iranian domestic chicken flocks. Given the results of our study, it appears possible that resistance may be expected in the helminth parasite of poultry. Additional studies with a larger scale are required to determine the prevalence of anthelminthic resistance in the poultry industry.

show abstract

“…The results of our study revealed that Fenbendazole and Levamisole were more effective in eliminating A. galli. It should be noted that evidence of Fenbendazole resistance in A. dissimilis, a closely related ascarid of chickens, has been recently reported in turkey with a history of heavy administration of frequent intervals of Fenbendazole [21].…”

Section: Discussionmentioning

confidence: 98%

Anthelmintic efficacy of Fenbendazole and Levamisole in native fowl in northern Iran

Soudkolaei

Kalidari

Borji

2021

Preprint

View full text Add to dashboard Cite

Background: With the increasing number of free-range domestic chickens, helminth parasites have potentially become more of a threat in commercial flocks in recent years, and routine poultry deworming is needed to improve efficiency of chicken products. The present study deals with a field trial to study the efficiency of two generally used anthelmintics, Fenbendazole and Levamisole, against gastrointestinal nematodes of domestic chickens in north of Iran. Methods: Out of 45 domestic chicken flocks involved in the study, 20 flocks were selected to participate in fecal egg count reduction testing based on flock size from April 2017 to September 2018. The infected chickens were randomly divided into three equal groups of 30 each. Ninety chickens in the infected groups received one of the following treatments (d 0 of treatment): Group 1: 5 mg kg−1 body weight (BW) Fenbendazole for three consecutive days, Group 2: 16 mg kg−1 BW Levamisole, and Group 3 control: placebo; water + DMSO [1]. The efficiency of the treatments were evaluated by comparing fecal egg count in the treated and control groups.Results: Examination of 3 herds of chicken from the control group showed that 95.0% of the animals were infected with gastrointestinal nematodes with an average geometric value of 361 eggs per gram of feces. Fenbendazole at a dose of 5 mg kg−1 BW for three days showed an efficiency of 83.7% (P ≥0.05), and Levamisole at a dose of 16 mg kg−1 BW showed 71.8% (P ≥0.05) with geometric mean eggs in a gram of feces 100 and 199.6, respectively. In general, Fenbendazole and Levamisole showed significantly lower activity. The result of this study revealed that Fenbendazole was a better and effective dewormer than Levamisole on the three Iranian domestic chicken flocks, but it is not significant. Capillaria spp., were the most generally resistant nematodes followed by Trichostrongylus spp., and Amidostomum anseris.Conclusion: Our results indicated that Fenbendazole and Levamisole reduced number of nemathodes effectively in three Iranian domestic chicken flocks. Given the results of our study, it is possible that resistance may be expected in the parasitic helminths of poultry. Additional studies with a larger scale are required to determine the prevalence of anthelmintic resistance in the poultry industry.

show abstract

Resistance to fenbendazole in Ascaridia dissimilis, an important nematode parasite of turkeys

Cited by 31 publications

References 12 publications

Anthelmintic efficacy of fenbendazole and levamisole in native fowl in northern Iran

Anthelmintic efficacy of fenbendazole and levamisole in native fowl in northern Iran

Anthelminthic Efficacy of Fenbendazole and Levamisole in Native Fowl in Northern Iran

Anthelmintic efficacy of Fenbendazole and Levamisole in native fowl in northern Iran

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