Resistance to deltamethrin, fipronil and ivermectin in the brown dog tick, Rhipicephalus sanguineus sensu stricto, Latreille (Acari: Ixodidae)

Becker, Simone; Webster, Anelise; Doyle, Rovaina Laureano; Martins, João Ricardo; Reck, José; Klafke, Guilherme Marcondes

doi:10.1016/j.ttbdis.2019.05.015

Cited by 48 publications

(33 citation statements)

References 25 publications

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“…population examined was decided if RR at 50% was statistical different from the KNL population. The sampled populations were classi ed as susceptible when the RR was lower than 1.5, with incipient resistance when the RR was between 1.5 and 2 and resistant when the RR was higher than 2 (Becker et al 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Resistant strains of ticks can be diagnosed by scrutinizing tick populations using bioassays to compare susceptibility between populations and molecular assays for genotyping of resistance (FAO 2004). Bioassays have been used for determining pyrethroids and ivemectin resistance in R. sanguineus populations (Rodriguez-Vivas et al 2017a;Becker et al 2019). A point mutation conferring target site insensitivity to pyrethroids is common and has been observed in ticks (Guerrero et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Cypermethrin and ivermectin resistance in field populations of Rhipicephalus sanguineus sensu lato (Latrielle, 1806) collected from dogs in south India

et al. 2021

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The abuse of acaricides for control of Rhipicephalus sanguineus sensu lato ticks led to a strong selection pressure for acaricide resistance. Data on acaricide resistance in R. sanguineus s.l. populations from India is meager though veterinarians frequently report treatment failures. The present study was aimed to characterize the level of resistance in R. sanguineus s.l. against most commonly used drugs, cypermethrin and ivermectin in Andhra Pradesh, south India. Fourteen adult female tick populations were collected from naturally infested dogs at veterinary clinics, residence and stray dog in nine state municipal corporations/municipalities. Information on the history of dog treatment with acaricides was obtained by interviewing dog owners. The larval packet test (LPT) and larval immersion test (LIT) were used on the larvae of ticks to test for resistance to cypermethrin and ivermectin, respectively. Mortality data of each tick population was analyzed by probit analysis. Corresponding to the most susceptible population, thirteen (92.6%) and six (42.9%) tick populations were regarded as resistant to cypermethrin and ivermectin, respectively. The phenotypic level of cypermethrin (resistance ratios at LC50% varied from 1.55 to 13.29) and ivermectin (resistance ratios at LC50% ranged from 1.16 to 4.79) resistance varied distinctly between the populations. Additionally, all the populations were tested using PCR to demonstrate the frequency of the point mutation in sodium channel gene that corresponds with resistance of R. sanguineus s.l. to cypermethrin. A nucleotide substitution (T2134C) on domain III segment VI of the sodium channel gene was noticed in phenotypically resistant tick populations on DNA sequencing. Ivermectin resistance in the brown dog ticks is reported for the rst time from India.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cypermethrin and ivermectin resistance in field populations of Rhipicephalus sanguineus sensu lato (Latrielle, 1806) collected from dogs in south India

et al. 2021

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“…Interestingly, all of the drugs mentioned in the control of ectoparasites, with the exception of fipronil, are the latest to be released on the market. Frequent use of ectoparasiticides may exert a selection pressure for resistance or tolerance in tick populations (Rodriguez-Vivas et al, 2017;Becker et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Faced with the emergence of antiparasitic drug resistance (Furtado et al, 2014;Becker et al, 2019), Brazilian veterinary practitioners have an important role in ensuring the sustainable control of the large diversity of gastrointestinal helminths and arthropods that affect dogs. The present study, therefore, aimed to evaluate the practical experience and methods employed by veterinary practitioners for parasite control in dogs in Brazil, using a structured questionnaire format.…”

Section: Guidelinesmentioning

confidence: 99%

Practices employed by veterinary practitioners for controlling canine gastrointestinal helminths and ectoparasites

Vale

Sousa

Tavares

et al. 2021

Rev. Bras. Parasitol. Vet.

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The present study attempted to evaluate the practical experience and methods employed by Brazilian veterinary practitioners for control of parasites. Twenty-one questions were asked of 403 veterinary practitioners based in different climatic zones with reference to parasite epidemiology from the country. Administration of a combination of drugs at three-month intervals was the most common regime recommended for prophylaxis against gastrointestinal helminths, with a single treatment repeated after 15 days. Routine prophylaxis against dog ectoparasites was recommended by 82.4% veterinary practitioners, and 46.6% changed the drug compound used. Monthly prophylaxic treatments for ectoparasites, using systemic, topical and/or collar-impregnated drugs, was recommended by 21.5% veterinary practitioners. Side-effects of ectoparasiticide-impregnated collars were suspected by 58% of the veterinary practitioners. Isoxazolines were the most frequently used chemical group to treat ectoparasites in dogs. Poor efficacy of fipronil in controlling ticks was suspected by 79.5% of the veterinary practitioners. The isoxazolines and combination of anthelmintic compounds are the most common drugs to prevent or treat ectoparasites and gastrointestinal nematodes, respectively. The suspect of the inefficacy of antiparasitic drugs is shared among the veterinary practitioners from part of Brazil. Guidelines are needed, specifically for the control of gastrointestinal helminths and ectoparasites in Brazilian dogs.

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“…Especially in the case of flea infestations, control strategies should rely on an owner’s compliance because of the massive presence of environmental stages and frequent cohabitation or contact with other flea-carrier pets in the same home [ 15 ]. The concern for health issues raised by fleas and ticks is highlighted by drivers potentially fostering a geographical expansion of key species in many regions of the globe [ 17 – 19 ] and suspected or confirmed reduced efficacy of some molecules against certain strains [ 20 – 22 ].…”

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Resistance to deltamethrin, fipronil and ivermectin in the brown dog tick, Rhipicephalus sanguineus sensu stricto, Latreille (Acari: Ixodidae)

Cited by 48 publications

References 25 publications

Cypermethrin and ivermectin resistance in field populations of Rhipicephalus sanguineus sensu lato (Latrielle, 1806) collected from dogs in south India

Cypermethrin and ivermectin resistance in field populations of Rhipicephalus sanguineus sensu lato (Latrielle, 1806) collected from dogs in south India

Practices employed by veterinary practitioners for controlling canine gastrointestinal helminths and ectoparasites

Credelio® Plus: a novel oral endectocide for dogs

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