Resistance to Colistin in
            <i>Acinetobacter baumannii</i>
            Associated with Mutations in the PmrAB Two-Component System

Adams, Mark D.; Nickel, Gabrielle C.; Bajaksouzian, Saralee; Lavender, Heather; Murthy, A. Rekha; Jacobs, Michael; Bonomo, Robert A.

doi:10.1128/aac.00284-09

Cited by 398 publications

(343 citation statements)

References 51 publications

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“…The mechanism of resistance to CS, Col(r), in A. baumannii was analyzed by Adams et al 24 They selected in vitro Col(r) derivatives of the multidrug-resistant A. baumannii isolate (AB0057). The DNA sequencing identified mutations in genes encoding proteins PmrA and/or PmrB in each strain and also in a Col(r) clinical isolate.…”

Section: Discussionmentioning

confidence: 99%

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Medell¹,

Medell²,

Martínez³

et al. 2012

Braz J Infect Dis

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Objective: This observational study described the characterization of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units.The demonstration of isolated microorganism resistance to antibiotics and a time-trend analysis of infection comparing a 48-month period were also other objectives.Method: Semi-quantitative assays of 1254 samples taken from 741 ventilated patients were performed, while pathogens were identified using the Enterotube II assay and VITEK 2 Compact equipment. Bacterial resistance to antibiotics was assessed by the Kirby-Bauer disc diffusion method and time-trend analysis of infection was based on data recorded by hospital microbiology laboratories.

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Section: Discussionmentioning

confidence: 99%

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Medell¹,

Medell²,

Martínez³

et al. 2012

Braz J Infect Dis

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“…The main mechanisms of resistance these antibiotics involve: (i) reduction of the net negative charge of the outer-membrane protein by modification of lipid A, an essential component of the bacterial lipopolysaccharide (LPS); and (ii) proteolytic cleavage of the antimicrobial compound and exclusion of peptides by a broadspectrum efflux-pump. In A. baumannii, point mutations and frameshifts in the pmrA and pmrB genes have been shown to cause an increase in colistin MICs (46). PmrAB is a two-component system involved in environmental sensing of pH and ion concentration.…”

Section: Genetic Basis Of Resistance To Colistin and Polymyxinsmentioning

confidence: 99%

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

2011

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SummaryAntibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic b-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mechanisms of resistance have been identified in A. baumannii. The very high genetic plasticity of A. baumannii allows an accumulation of resistance determinants that give rise to multidrug resistance at an alarming rate. The role of novel genetic elements, such as resistance islands, in concentrating antibiotic resistance genes in A. baumannii requires detailed investigation in the near future.

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“…5 Previous microarray data show that expression levels of genes associated with the pmrAB regulon 6,7 were decreased in a triple mutant lacking the transcription factors MarA, Rob, and SoxS compared with its parent strain, when extracted from a murine pyelonephritis infection model. 6 The pmrAB operon encodes a two-component regulatory system present in many bacterial species, 8,9 which mediates a wide range of functions, most notably modification of the lipid A moiety of lipopolysaccharide (LPS). 10,11 Such modification of LPS alters the host immune response to the bacterial pathogen, and indeed, studies in Salmonella enterica serovar Typhimurium 12 and Francisella novicida 13 show that pmrAB contributes to virulence in animal models of infection.…”

Section: Introductionmentioning

confidence: 99%

The contribution of PmrAB to the virulence of a clinical isolate ofEscherichia coli

2013

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Resistance to Colistin in Acinetobacter baumannii Associated with Mutations in the PmrAB Two-Component System

Cited by 398 publications

References 51 publications

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Characterization and sensitivity to antibiotics of bacteria isolated from the lower respiratory tract of ventilated patients hospitalized in intensive care units

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

The contribution of PmrAB to the virulence of a clinical isolate ofEscherichia coli

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