Resistance risk assessment of mefentrifluconazole in Corynespora cassiicola and the control of cucumber target spot by a two-way mixture of mefentrifluconazole and prochloraz

Peng, Qin; Li, Xiuhuan; Li, Guixiang; Hao, Xinchang; Liu, Xili

doi:10.1016/j.pestbp.2023.105719

Cited by 1 publication

(2 citation statements)

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“…fructicola . The overexpression of CcCYP51A and CcCYP51B also was associated with mefentrifluconazole resistance in Corynespora cassiicola . Overexpression of cyp51A , AtrF , AfuMDR1 , and AfuMDR4 were associated with the acquired mefentrifluconazole resistance in Aspergillus fumigatus with hereditary stability .…”

Section: Discussionmentioning

confidence: 92%

“…29 The overexpression of CcCYP51A and CcCYP51B also was associated with mefentrifluconazole resistance in Corynespora cassiicola. 30 Overexpression of cyp51A, AtrF, Af uMDR1, and Af uMDR4 were associated with the acquired mefentrifluconazole resistance in Aspergillus fumigatus with hereditary stability. 31 This investigation discovered the L144F substitution in FpCYP51B in four mutants that exhibited resistance to mefentrifluconazole.…”

Section: Discussionmentioning

confidence: 99%

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Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of Fusarium pseudograminearum

Li,

Ru,

Zhang

et al. 2024

J. Agric. Food Chem.

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Mefentrifluconazole, a triazole fungicide, exhibits remarkable efficacy in combating Fusarium spp. The mean EC50 value of mefentrifluconazole against 124 isolates of Fusarium pseudograminearum was determined to be 1.06 μg/mL in this study. Fungicide taming produced five mefentrifluconazole-resistant mutants with resistance factors ranging from 19.21 to 111.34. Compared to the original parental isolates, the fitness of three resistant mutants was much lower, while the remaining two mutants displayed enhanced survival fitness. There was evidence of positive cross-resistance between tebuconazole and mefentrifluconazole. Mefentrifluconazole resistance in F. pseudograminearum can be conferred by FpCYP51BL144F, which was identified in four mutants according to molecular docking and site-directed transformation experiments. Overexpression of FpCYP51s was also detected in the resistant mutants. In conclusion, mefentrifluconazole has a low-to-medium resistance risk in F. pseudograminearum, and the L144F mutation in FpCYP51B and the increased expression level of FpCYP51s may be responsible for mefentrifluconazole resistance in F. pseudograminearum.

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