Resistance phenotype and genetic features of a heterogeneous vancomycin intermediate–resistant Staphylococcus aureus strain from an immunocompromised patient

Cheng, Xin; Wang, Yaru; Ma, Jingxin; Ma, Liyan; Sun, Wei; Su, Jianrong

doi:10.1007/s42770-023-01192-y

Cited by 1 publication

(1 citation statement)

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“…Hence, the proportion of hVISA /VISA will affect the detection efficiency. Second, both hVISA and VISA are unstable and can revert to a sensitive state under certain conditions [ 25 ]. Therefore, timely detection is crucial for hVISA/VISA.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of BHI-V4 for heterogeneous and vancomycin-intermediate Staphylococcus aureus isolates: a systematic review and meta-analysis

Cheng,

Zhou,

Yuan

et al. 2024

BMC Infect Dis

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Background Brain-heart infusion agar supplemented with 4 µg/mL of vancomycin (BHI-V4) was commonly used for the detection of heterogeneous (hVISA) and vancomycin-intermediate Staphylococcus aureus (VISA). However, its diagnostic value remains unclear. This study aims to compare the diagnostic accuracy of BHI-V4 with population analysis profiling with area under the curve (PAP-AUC) in hVISA/VISA. Methods The protocol of this study was registered in INPLASY (INPLASY2023120069). The PubMed and Cochrane Library databases were searched from inception to October 2023. Review Manager 5.4 was used for data visualization in the quality assessment, and STATA17.0 (MP) was used for statistical analysis. Results In total, eight publications including 2153 strains were incorporated into the meta-analysis. Significant heterogeneity was evident although a threshold effect was not detected across the eight studies. The summary receiver operating characteristic (SROC) was 0.77 (95% confidence interval [CI], 0.74–0.81). The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic score and diagnostic odds ratio were 0.59 (95% CI: 0.46–0.71), 0.96 (95%CI: 0.83–0.99), 14.0 (95% CI, 3.4–57.1), 0.43 (95%CI, 0.32–0.57), 3.48(95%CI, 2.12–4.85) and 32.62 (95%CI, 8.31-128.36), respectively. Conclusion Our study showed that BHI-V4 had moderate diagnostic accuracy for diagnosing hVISA/VISA. However, more high-quality studies are needed to assess the clinical utility of BHI-V4.

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Section: Discussionmentioning

confidence: 99%