Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1

Tencati, Michael; Tapping, Richard I.

doi:10.1128/iai.00488-16

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…alleles conferring resistance to Y. pestis in mice supports existence of heritable resistance traits in rodent species (Tencati & Tapping, 2016;Turner et al, 2008). More broadly, we observe a wide range of Y. pestis resistance at the population level across different small mammal species and populations, which could be a sign of additive genetic variance in Y. pestis resistance (Biggins & Kosoy, 2001).…”

Section: Box 2 Reduction Analysis Of Model Processes (Ramp)supporting

confidence: 67%

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Host adaptation to novel pathogen introduction: Predicting conditions that promote evolutionary rescue

2021

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Novel pathogen introduction can have drastic consequences for naive host populations, and outcomes can be difficult to predict. Evolutionary rescue (ER) provides a foundation for understanding whether hosts are driven to extinction or survive via adaptation. Currently, patterns of host population dynamics alongside evidence of adaptation are used to infer ER. However, the gap between established ER theory and complexity inherent in natural systems makes interpreting empirical patterns difficult because they can be confounded with ecological drivers of survival under current theory. To bridge this gap, we expand ER theory to include biological selective agents, such as pathogens. We find birth processes to be more important than previously theorised in determining ER potential. We employ a novel framework evaluating ER potential within natural systems and gain ability to identify system characteristics that make ER possible. Identifying these characteristics allows a shift from retrospective observation to a predictive mindset, and our findings suggest that ER occurrence may be more limited than previously thought. We use the plague system of Yersinia pestis infecting Cynomys ludovicianus (black‐tailed prairie dogs) and Spermophilus beecheyi (California ground squirrels) as a case study.

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Section: Box 2 Reduction Analysis Of Model Processes (Ramp)supporting

confidence: 67%

“…The discovery of genetic loci and alleles conferring resistance to Y . pestis in mice supports existence of heritable resistance traits in rodent species (Tencati & Tapping, 2016; Turner et al, 2008). More broadly, we observe a wide range of Y .…”

Section: Plague As a Motivating Examplementioning

confidence: 82%

Host adaptation to novel pathogen introduction: Predicting conditions that promote evolutionary rescue

2021

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Enterobacteria and host resistance to infection

et al. 2018

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Enterobacteriaceae are a large family of Gram-negative, non-spore-forming bacteria. Although many species exist as part of the natural flora of animals including humans, some members are associated with both intestinal and extraintestinal diseases. In this review, we focus on members of this family that have important roles in human disease: Salmonella, Escherichia, Shigella, and Yersinia, providing a brief overview of the disease caused by these bacteria, highlighting the contribution of animal models to our understanding of their pathogenesis and of host genetic determinants involved in susceptibility or resistance to infection.

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