Resistance of gastrointestinal nematodes to five different active principles in sheep infected naturally in São Paulo State, Brazil

Nagata, Walter Bertequini; Panegossi, Mariele Fernanda da Cruz; Bresciani, Kátia Denise Saraiva; Gomes, Jancarlo Ferreira; Kaneto, Carlos Noriyuki; Perri, Sílvia Helena Venturoli

doi:10.1016/j.smallrumres.2018.10.001

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Another study reported 51% efficacy of moxidectin upon evaluation in the regions of Londrina, Paraná (Buzzulin, Costa, Santos, Borges, & Soares, 2007), Jaboticabal, São Paulo (Rosalinski-Moraes et al, 2007, and Santa Catarina, in addition to other studies conducted in these regions (Cezar et al, 2010). Another study conducted in the same region reported approximately 45% efficacy of moxidectin (Almeida, Garcia, Torgerson, & Amarante, 2010), whereas a study conducted in São Paulo reported an efficacy of 95% (Nagata et al, 2019).…”

Section: Discussionmentioning

confidence: 92%

Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus

Portella

Fernandes

Sangioni

et al. 2021

Semina: Ciênc. Agrár.

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Considering the importance of Haemonchus contortus infection in herds along with parasitic resistance, the goal of this study was to evaluate the influence of the administration of adjuvants alone or in combination with anthelmintics for the treatment of H. contortus, in experimentally infected sheep. Thirty sheep of the Texel breed of both genders, raised in a herd located in the subtropical region of Brazil, were used in this experiment. Experimental infection with H. contortus was performed in sheep, and the infected sheep were then separated into groups for the administration of antiparasitic and immunostimulant drugs. The results obtained from the excretion of eggs per gram of feces and the count of parasites during necropsy affirm that the use of adjuvants in combination with anthelmintics is associated with higher efficacy of treatment, lower rate of reinfection, and retardation in the development of anthelmintic drug resistance by H. contortus. Based on these results, we can conclude that the combination of anthelmintics and immunostimulants may favor potential anthelmintic treatments for H. contortus.

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Section: Discussionmentioning

confidence: 92%

Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus

Portella

Fernandes

Sangioni

et al. 2021

Semina: Ciênc. Agrár.

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“…Cross- (or side-) resistance between MOX and other MLs is evident in many parasite species (and in C. elegans ), although the extent of resistance is typically significantly lower. Continued exposure to MOX in the field can lead to therapeutic failure at label doses (Condi et al, 2009; Gasbarre et al, 2009; El-Abdellati et al, 2010; Paraud et al, 2016; Canton et al, 2017; Ploeger and Everts, 2018; Nagata et al, 2019); whether further prolonging drug exposure in animals infected with highly resistant strains could maintain adequate control over time should be experimentally evaluated.…”

Section: Attributes Of Moxidectin That May Reduce Selection For Resismentioning

confidence: 99%

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

Prichard

Geary

2019

International Journal for Parasitology: Drugs and Drug Resistan

108

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Macrocyclic lactone (ML) anthelmintics are the most important class of anthelmintics because of our high dependence on them for the control of nematode parasites and some ectoparasites in livestock, companion animals and in humans. However, resistance to MLs is of increasing concern. Resistance is commonplace throughout the world in nematode parasites of small ruminants and is of increasing concern in horses, cattle, dogs and other animals. It is suspected in Onchocerca volvulus in humans. In most animals, resistance first arose to the avermectins, such as ivermectin (IVM), and subsequently to moxidectin (MOX). Usually when parasite populations are ML-resistant, MOX is more effective than avermectins. MOX may have higher intrinsic potency against some parasites, especially filarial nematodes, than the avermectins. However, it clearly has a significantly different pharmacokinetic profile. It is highly distributed to lipid tissues, less likely to be removed by ABC efflux transporters, is poorly metabolized and has a long half-life. This results in effective concentrations persisting for longer in target hosts. It also has a high safety index. Limited data suggest that anthelmintic resistance may be overcome, at least temporarily, if a high concentration can be maintained at the site of the parasites for a prolonged period of time. Because of the properties of MOX, there are reasonable prospects that strains of parasites that are resistant to avermectins at currently recommended doses will be controlled by MOX if it can be administered at sufficiently high doses and in formulations that enhance its persistence in the host. This review examines the properties of MOX that support this contention and compares them with the properties of other MLs. The case for using MOX to better control ML-resistant parasites is summarised and some outstanding research questions are presented.

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“…Increasing numbers of intestinal parasite infections in small ruminant production systems around the world has become an increasing concern due to the widespread development of resistance of helminths to pharmaceutical treatments [26]. In a recent study of 350 sheep from five farms, commercial anthelmintic drugs were evaluated as to their efficacy in reducing fecal egg counts [27]. While all drugs were effective, each showed resistance to the drugs to varying degrees: Albendazole 33%, Levamisole hydrochloride 25%, Ivermectin 48%, Moxidectin 14%, Closantel 23%, and Ivermectin + Levamisole + Albendasole combination 30%.…”

Section: Managementmentioning

confidence: 99%

Fighting the Deadly Helminthiasis without Drug Resistance

Haenlein

Park

2020

Dairy

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Helminthiasis is a very costly management problem in the sheep and goat industry, because the gastrointestinal parasites develop resistance against all chemical products that are discovered and produced by the pharmaceutical industry. The use of natural herbal contents of tannin as especially in Sericea Lespedeza (SL; Lespedeza cuneate) is very promising. Utilizing genetic differences in resistance among the different goat and sheep breeds is a promising alternative, with limited success to date. Totally eliminating the offending parasites from re-infesting by plowing under affected pastures for some seasons, or scheduling rotational pastures, or feeding fresh (grazed) or dried forms of the perennial warm-season legume sericea lespedeza to the infected sheep and goats, or using elevated housing with slatted floors are the most promising alternatives to the ancient tradition of herding and managing ruminants by transhumance. An elevated slatted floor housing is desirable, and deserves wider attention because of its potential in controlling helminthiasis. Slatted floors are already used in the sheep and goat industries in Sweden, Norway, Malaysia and Guatemala.

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Resistance of gastrointestinal nematodes to five different active principles in sheep infected naturally in São Paulo State, Brazil

Cited by 7 publications

References 19 publications

Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus

Combination of immunostimulants with moxidectin in the treatment of animals experimentally infected with Haemonchus contortus

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

Fighting the Deadly Helminthiasis without Drug Resistance

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