Resistance is costly for Candida

Kåhrström, Christina Tobin

doi:10.1038/nrmicro3454

Cited by 5 publications

(6 citation statements)

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“…Fungi are increasingly recognized as important pathogens in critically ill and immunocompromised patients (32)(33)(34)(35)(36). The incidence of invasive candidiasis has increased over the past decade due to the increasing prevalence of immunosuppressive therapy, invasive surgical procedures, and use of indwelling medical devices (13).…”

Section: Discussionmentioning

confidence: 99%

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Husni

Zerdan²,

Samaha³

et al. 2023

Front. Public Health

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BackgroundInvasive fungal infections have presented a challenge in treatment. In the past, it was known that the frontrunner in such infections is Candida albicans with little emphasis placed on non-albicans Candida species (NAC). Studies worldwide have shown a rise in fungal infections attributed to non-albicans Candida species. The aim of this study is to describe the epidemiology of NAC infections along with an overview of resistance in Lebanese hospitals.MethodsThis is a two-year observational multi-central descriptive study. Between September 2016 and May of 2018, a total of 1000 isolates were collected from 10 different hospitals distributed all over the country. For the culture, Sabouraud Dextrose Agar was used. Antifungal Susceptibility was evaluated by determining the Minimum Inhibitory Concentration (MIC) in broth (microdilution) of the different antifungal treatments.ResultsOut of the 1000 collected isolates, Candida glabrata, being the most isolated species (40.8%), followed by Candida tropicalis: 231(23.1%), Candida parapsilosis: 103(10.3%), and other NAC species at lower percentage. Most of these isolates (88.67%) were susceptible to posaconazole, 98.22% were susceptible to micafungin, and 10% were susceptible to caspofungin.ConclusionThe change of etiology of fungal infections involving a significant increase in NAC cases is alarming due to the different antifungal susceptibility patterns and the lack of local guidelines to guide the treatment. In this context, proper identification of such organisms is of utmost importance. The data presented here can help in establishing guidelines for the treatment of candida infections to decrease morbidity and mortality. Future surveillance data are needed.

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Section: Discussionmentioning

confidence: 99%

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Husni

Zerdan²,

Samaha³

et al. 2023

Front. Public Health

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“…Durante os últimos anos, a literatura vem descrevendo a atividade antimicrobiana de diferentes compostos 1,2,4-oxadiazólicos (Cunha, Aguiar, 2015;Gobec et al, 2015;Kahrstrom, 2015;Freitas et al, 2012;Bora et al, 2014). Motivados por essas pesquisas, e na perspectiva de obter um composto eficaz e estruturalmente simples, o trabalho foi iniciado com a síntese da benzamidoxima utilizando o protocolo de Almeida et al (2018), com algumas modificações, conforme descrito na Figura 3.…”

Section: Resultsunclassified

“…Nesse contexto, a literatura descreve vários estudos utilizando compostos contendo o anel 1,2,4-oxadiazólico (Figura 1) com promissora atividade antimicrobiano (Cunha, Aguiar, 2015;Gobec et al, 2015;Kahrstrom, 2015). Research, Society and Development, v. 9, n. 7, e601974523, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i7.4523 Fonte: Próprios autores, 2020.…”

Section: Introductionunclassified

“…Estrutura do anel 1,2,4-oxadiazólico destacado em azul.Fonte: Próprios autores, 2020.Os 1,2,4-oxadiazóis são heterocíclicos que podem atuar como: antiasmático, antidiabético, agente anti-inflamatório, agente antitumoral, agente neuroprotetor, imunossupressor, antioxidante e agente antimicrobiano(Cunha, Aguiar, 2015;Gobec et al, 2015;Kahrstrom, 2015). Tale et al(2011)destacaram a atividade antifúngica de diferentes compostos 1,2,4-oxadiazólicos frente aos fungos Aspergillus niger e Fusarium solani (Figura 2).…”

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Síntese do 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol e avaliação do seu potencial toxicológico e antifúngico

Morais¹,

Medeiros

Jorge³

et al. 2020

RSD

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In recent years, mycoses have become a serious public health problem, mainly due to the increase in the number of people with immunodeficiency, innate or acquired, and the appearance of multiresistant microorganisms due to the indiscriminate use of antibiotics. In order to minimize these problems, compounds containing the 1,2,4-oxadiazolic ring are the target of numerous pharmacological and toxicological studies aimed at developing new, more potent and selective antimicrobials. Thus, the present study aimed to evaluate the toxicological and antifungal potential of the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol. The synthesis of compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was carried out from the reaction between benzamidoxime and ethyl salicylate. Toxicological potential was evaluated using the microcustacean Artemia salina Leach. The evaluation of the antifungal potential was carried out against different strains of potentially pathogenic fungi, using the serial microdilution technique. After 24h of reaction, the compound 2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenol was obtained with 72% yield, had a melting point of 159-160ºC and the 1H and 13C NMR data corroborate its structure. The compound showed low toxicity against the brine shrimp, with an LC50 of 565,100 μg/mL, while the Minimum Inhibitory Concentration and Minimum Fungicidal Concentration showed equal values of 4000 μg/mL for the fungus Rhizopus orizae. These results encourage other studies, since compound showed low toxicity and reduced spectrum of action, which favours the treatment of specific fungal infections.

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“…Um fator relevante a ressaltar é o preocupante aumento de fungos resistentes aos antifúngicos disponíveis no mercado, em decorrência, muitas vezes, do uso indiscriminado de antimicrobianos (BERGAMO et al, 2015;KAHRSTROM, 2015;MOREIRA et al, 2017). O recente isolamento no Brasil de uma nova espécie de Candida em um paciente acometido por COVID-19, vem despertando preocupação às autoridades sanitárias.…”

Section: Introductionunclassified

Experiências Vivenciadas Em Um Projeto De Pesquisa Intitulado “Contribuição Ao Estudo Da Efetividade E Segurança De Antifúngicos Utilizados Para Tratamento De Micoses Superficiais”

Cândido

Vicente

Medeiros

et al. 2021

Edu., Ciência e Saúde

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O presente trabalho objetivou relatar de forma reflexiva e crítica as experiências vivenciadas durante a realização de um projeto de pesquisa do PIBIC realizado em uma farmácia comercial localizada na cidade de Cuité-PB. O estudo descritivo, tipo relato de experiência, foi realizado por graduandos do curso de farmácia, no período de agosto de 2017 a julho de 2018, após aprovação sob parecer 2.446.611, durante a realização de um PIBIC intitulado: "Contribuição ao estudo de efetividade e segurança de antifúngicos utilizados para o tratamento de micoses superficiais". Identifica-se que dos 35 pacientes entrevistados, cinco enquadram-se nos critérios de inclusão, dos quais quatro queixavam-se de tinea unguium e um de pitiríase versicolor. A maioria buscou os antifúngicos por indicação farmacêutica. Embora o projeto não tenha se desenvolvido como planejado e obtido resultados numericamente representativos, o estudo permitiu o contato dos discentes com algumas áreas de atuação farmacêutica.

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Resistance is costly for Candida

Cited by 5 publications

References 1 publication

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Síntese do 2-(3-fenil-1,2,4-oxadiazol-5-il)fenol e avaliação do seu potencial toxicológico e antifúngico

Experiências Vivenciadas Em Um Projeto De Pesquisa Intitulado “Contribuição Ao Estudo Da Efetividade E Segurança De Antifúngicos Utilizados Para Tratamento De Micoses Superficiais”

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