Resistance Index Measured by Doppler Ultrasound as a Predictor of Graft Function After Kidney Transplantation

Cano, Haroold; Castañeda, D.A.; Patiño, Nasly; Pérez, Hernando; Sanchez, M. A.; Lozano, E.; Perez, Marjo Cardenuto

doi:10.1016/j.transproceed.2014.07.001

Cited by 24 publications

(30 citation statements)

References 15 publications

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“…Consequently, evaluation of the renal transplant resistance index (RI) may help detect acute graft dysfunction [21–23]. However, RI measurements cannot differentiate AR from acute tubular necrosis (ATN), calcineurin inhibitor toxicity, renal vein thrombosis, ureteral obstruction or pyelonephritis [22]. In case of delayed graft function (DGF) [24], sequential Doppler US does not help specifically detect AR.…”

Section: Ultrasoundmentioning

confidence: 99%

Non-invasive approaches in the diagnosis of acute rejection in kidney transplant recipients. Part I.In vivoimaging methods

et al. 2016

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Kidney transplantation (KTx) represents the best available treatment for patients with end-stage renal disease. Still, full benefits of KTx are undermined by acute rejection (AR). The diagnosis of AR ultimately relies on transplant needle biopsy. However, such an invasive procedure is associated with a significant risk of complications and is limited by sampling error and interobserver variability. In the present review, we summarize the current literature about non-invasive approaches for the diagnosis of AR in kidney transplant recipients (KTRs), including in vivo imaging, gene expression profiling and omics analyses of blood and urine samples. Most imaging techniques, like contrast-enhanced ultrasound and magnetic resonance, exploit the fact that blood flow is significantly lowered in case of AR-induced inflammation. In addition, AR-associated recruitment of activated leukocytes may be detectable by 18F-fluoro-deoxy-glucose positron emission tomography. In parallel, urine biomarkers, including CXCL9/CXCL10 or a three-gene signature of CD3ε, IP-10 and 18S RNA levels, have been identified. None of these approaches has been adopted yet in the clinical follow-up of KTRs, but standardization of procedures may help assess reproducibility and compare diagnostic yields in large prospective multicentric trials.

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Section: Ultrasoundmentioning

confidence: 99%

Non-invasive approaches in the diagnosis of acute rejection in kidney transplant recipients. Part I.In vivoimaging methods

et al. 2016

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“…[19] Renal RI is considered to be normal at <0.7, indeterminate between 0.7-0.8, and elevated at >0.8. [20] Importantly, there are no such reference values for clubfoot in babies. To the best of our knowledge, this is the first study regarding this issue.…”

Section: Discussionmentioning

confidence: 99%

Resistive index and peak systolic velocity for congenital talipes equinovarus: A color Doppler ultrasonography study

et al. 2020

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Congenital talipes equinovarus (clubfoot) is a disease that is treated frequently in orthopedics clinics. Its incidence is 1-2 per 1,000 live births. [1] Cavus, adductus, varus, and equinus deformities are observed in clubfoot patients; [2] each of these contributes to various bone, muscle, vascular, and neurological problems. [3] Vascular deficiencies have been suggested as one of the underlying etiologies of clubfoot. Various studies using arteriography, [3] continuous wave Doppler ultrasonography (DU), [4] color Doppler ultrasonography (CDU), [2,4-6] and magnetic resonance image angiography [3,7] were performed to show arterial patterns in clubfoot patients. Deficiency of the anterior tibial artery and dorsalis pedis (dp) artery were demonstrated in 6.7-86% of patients. [4] Many researchers have reported that CDU is a reliable technique and can be used as a suitable alternative for arteriography. [1,8] Several CDU studies have been undertaken to investigate the arterial structures in clubfoot patients. In these studies, Objectives: This study aims to investigate whether resistive index (RI) and peak systolic velocity (PSV) are suitable parameters to determine if a clubfoot differs from feet of the normal population. Patients and methods: Fifty-four feet of 27 clubfoot patients (22 males, 5 females; mean age 30.4±16.3 months; range, 5 to 72 months) were included in this retrospective study conducted between December 2017 and January 2019. Twentyseven feet were conservatively treated, 19 had surgical treatment, and eight feet were healthy in patients with unilateral clubfoot. In addition, 22 feet of 11 normal controls (6 males, 5 females; mean age 33.4±15.3 months; range, 15 to 60 months) were studied. Color Doppler ultrasonography examinations were performed to evaluate the three major arteries of the leg and foot: dorsalis pedis (dp), tibialis posterior (tp), and popliteal (pop). Color filling, flow direction, spectral analysis, velocity, and RI were examined. Results: With the exception of the dp artery RI, the PSV and RI values for all arteries differed significantly from those of the control group. There were no significant differences among the conservative, surgical, and healthy groups, while there were significant differences between each of the treated groups and the control group. Tibialis posterior artery PSV and pop artery RI were the best parameters to identify clubfoot and the cutoff points were 54 cm/second and 0.77, respectively. Conclusion: Peak systolic velocity and RI may be accepted as important parameters for identification of clubfoot deformity. Tibialis posteriorartery PSV and pop artery RI are the bestdetailed parameters for this examination.

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“…In addition, according to research cited in the literature, there is no agreement on the resistance index (RI). Some studies have demonstrated that RI was a reliable marker to assess kidney function [ 12 - 14 ], but others have shown the opposite [ 11 , 16 - 18 ]. Hence, more research needs to be done to test RI before it can be recommended for use in clinical centres.…”

Section: Discussionmentioning

confidence: 99%

Scintigraphic texture analysis for assessment of renal allograft function

Ardakani¹,

Hekmat²,

Abolghasemi³

et al. 2018

Pol J Radiol

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PurposeEarly detection and monitoring of kidney function during the post-transplantation period is one of the most important issues for improving the accuracy of an initial diagnosis. The aim of this study was to evaluate texture analysis (TA) in scintigraphic imaging to detect changes in kidney status after transplantation.Material and methodsScintigraphic images were used for TA from a total of 94 kidney allografts (39 rejected and 55 non-rejected). Images corresponding to the frames at the 2nd, 5th, and 20th minute of the study were used to determine the optimum time point for analysis of differences in texture features between the rejected and non-rejected allografts.ResultsLinear discriminant analysis indicated the best performance at the fifth minute frame for classification of the rejected and non-rejected allografts with receiver operating characteristic curve (Az) of 0.982, corresponding to 91.89% sensitivity, 96.49% specificity, and 94.68% accuracy. Also, TA can differentiate acute tubular necrosis from acute rejection with Az of 0.953 corresponding to 88% sensitivity, 92.31% specificity, and 90.62% accuracy at the 5th minute frame. The best correlation between texture feature and kidney function was achieved at the 20th minute frame (r = –0.396) for glomerular filtration rate.ConclusionsTA has good potential for the characterisation of kidney failure after transplantation and can improve clinical diagnosis.

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Resistance Index Measured by Doppler Ultrasound as a Predictor of Graft Function After Kidney Transplantation

Cited by 24 publications

References 15 publications

Non-invasive approaches in the diagnosis of acute rejection in kidney transplant recipients. Part I.In vivoimaging methods

Non-invasive approaches in the diagnosis of acute rejection in kidney transplant recipients. Part I.In vivoimaging methods

Resistive index and peak systolic velocity for congenital talipes equinovarus: A color Doppler ultrasonography study

Scintigraphic texture analysis for assessment of renal allograft function

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