Resistance Exercise in Men Receiving Androgen Deprivation Therapy for Prostate Cancer

Segal, Roanne; Reid, Robert D.; Courneya, Kerry S.; Malone, Shawn; Parliament, Matthew; Scott, Christopher G.; Venner, Peter; Quinney, H. A.; Jones, Lee W.; D’Angelo, Monika E. Slovinec; Wells, George A.

doi:10.1200/jco.2003.09.534

Cited by 701 publications

(748 citation statements)

References 37 publications

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“…All seven group-based exercise studies 4,58,59,61,62,65,66 tended to show significant improvements in at least two of the three domains of physical fitness assessed, namely muscular strength, muscular endurance and aerobic endurance. In contrast, only two of the four home-based studies that assessed physical fitness measures found any significant improvements, and these were only observed for aerobic endurance 51,64 .…”

Section: Resultsmentioning

confidence: 96%

Body Composition, Physical Fitness, Functional Performance, Quality of Life, and Fatigue Benefits of Exercise for Prostate Cancer Patients: A Systematic Review

Keogh

MacLeod

2012

Journal of Pain and Symptom Management

182

167

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Context: Prostate cancer patients, especially those on androgen deprivation therapy (ADT) experience many symptoms that make it difficult to maintain their independence and quality of life. As ADT act via reducing testosterone production, exercise may offset many of the ADT side-effects and that of the cancer itself. Objectives: This article sought to conduct a systematic review of the literature on whether exercise could reduce symptoms and improve quality of life for prostate cancer patients. Methods: Using relevant databases and keywords, 12 training studies were found meeting the inclusion and exclusion criteria. Results: Grade A level evidence was observed for the benefits of exercise in improving muscular endurance, aerobic endurance and overall quality of life as well as reducing fatigue in prostate cancer patients. Grade B evidence also suggested that exercise may improve prostate cancer patients' muscle mass, muscular strength, functional performance (walking and sit to stand speed) as well as health-related, social and physical quality of life. These effects appeared greater for group-rather than home-based exercise; especially if these programs including resistance training. Conclusion: It is recommended that most prostate cancer patients be encouraged to exercise regularly by their clinicians and significant others. Where possible, this exercise should be group-based and include some resistance training. Future research in this area should directly compare group-and home-based as well as resistance, aerobic and combined resistance and aerobic training to better elucidate the most effective forms of exercise for this population and what factors affect initiation and adherence to such programs.

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Section: Resultsmentioning

confidence: 96%

Body Composition, Physical Fitness, Functional Performance, Quality of Life, and Fatigue Benefits of Exercise for Prostate Cancer Patients: A Systematic Review

Keogh

MacLeod

2012

Journal of Pain and Symptom Management

182

167

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“…Inclusion criteria included type 2 diabetes mellitus as defined by the American Diabetes Association [13] for at least 6 months and baseline HbA 1c of 6.6% to 9.9%. Potential participants were excluded if they: (1) were receiving insulin therapy; (2) were participating in exercise ≥2 times per week for at least 20 min per session or had been in any resistance training during the previous 6 months; (3) reported changes in oral hypoglycaemic medications during the previous 2 months; (4) reported changes in antihypertensive or lipidlowering agents in the previous month; (5) reported a change of ≥5% in body weight during the previous 2 months; (6) had serum creatinine ≥200 μmol/l; (7) had proteinuria >1 g/24 h; (8) had blood pressure >160/95 mmHg; (9) had restrictions in physical activity due to disease; (10) had other medical conditions making participation inadvisable; or (11) completed fewer than ten of the 12 scheduled exercise sessions during the run-in period.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies, however, have reported particularly beneficial effects of resistance exercise training on these outcomes in other clinical populations including patients with cardiac disease [9], the frail elderly [10] and men with prostate cancer receiving androgen deprivation therapy and/or radiotherapy [11,12].…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

et al. 2009

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Aims/hypothesis The Diabetes Aerobic and Resistance Exercise (DARE) study showed that aerobic and resistance exercise training each improved glycaemic control and that a combination of both was superior to either type alone in patients with type 2 diabetes mellitus. Here we report effects on patient-reported health status and well-being in the DARE Trial. Methods We randomised 218 inactive participants with type 2 diabetes mellitus in parallel to 22 weeks of aerobic exercise (n=51), resistance exercise (n=58), combined aerobic and resistance exercise (n=57) or no exercise (control; n=52). Intervention allocation was managed by a central office. Outcomes included health status as assessed by the physical and mental component scores of the Medical Outcomes Trust Short-Form 36-item version (SF-36) and well-being as measured by the Well-Being Questionnaire 12-item version (WBQ-12); these were measured at the Ottawa Hospital. Results Using a p value of 0.0125 for statistical significance due to multiple comparisons, mixed model analyses indicated that resistance exercise led to clinically but not statistically significant improvements in the SF-36 physical component score compared with aerobic exercise (Δ=2.7 points; p=0.048) and control (i.e. no exercise; Δ=3.3 points; p=0.015). For mental component scores, there were clinically important improvements favouring no (control) compared with resistance (Δ=7.6 points; p<0.001) and combined (Δ=7.2 points; p<0.001) exercise. No effects on WBQ-12 scores were noted. Overall, 59/218 (27%) of participants included in this analysis sustained an adverse event during the course of the study, including 16 participants in the combined exercise group, 19 participants in the resistance exercise group, 16 participants in the Electronic supplementary material The online version of this article

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“…Segal et al 57 studied the effects of resistance exercise training on muscle strength and QOL in men with PC. Specifically, 155 men diagnosed with PC who were undergoing ADT were randomized to an exercise group or a control group.…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

“…They found that participants in the exercising group were more likely to have increased upper and lower body strength, increased QOL measures and decreased fatigue as compared to men in the control group. 57 In a similar study, 66 patients with PC receiving radiation therapy were randomized to an exercise intervention group or a control group. In this study, the exercise intervention was home-based aerobic exercise therapy three times weekly for 16 weeks.…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

Exercise therapy across the prostate cancer continuum

Antonelli

Freedland

Jones

2009

Prostate Cancer Prostatic Dis

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Exercise has been increasingly investigated as an adjunct therapy for cancer patients. The purpose of this paper is to comprehensively review the literature regarding exercise as a therapeutic adjunct for prostate cancer (PC). Several studies in patients with PC have shown quality of life improvements associated with exercise. Although no study has established the effect of exercise as a monotherapy for PC, the molecular mechanisms responsible for the potential association between exercise and PC are being elucidated. Given the low-risk, high-reward nature of these studies, further investigations are needed to better define the function of exercise along the PC continuum.

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Resistance Exercise in Men Receiving Androgen Deprivation Therapy for Prostate Cancer

Abstract: Resistance exercise reduces fatigue and improves quality of life and muscular fitness in men with prostate cancer receiving androgen deprivation therapy. This form of exercise can be an important component of supportive care for these patients.

Cited by 701 publications

References 37 publications

Body Composition, Physical Fitness, Functional Performance, Quality of Life, and Fatigue Benefits of Exercise for Prostate Cancer Patients: A Systematic Review

Body Composition, Physical Fitness, Functional Performance, Quality of Life, and Fatigue Benefits of Exercise for Prostate Cancer Patients: A Systematic Review

Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

Exercise therapy across the prostate cancer continuum

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