Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice

Cheers, Christina; Pavlov, H; Waid, C; York, James L.

doi:10.1128/iai.19.3.763-770.1978

Cited by 119 publications

(54 citation statements)

References 15 publications

(13 reference statements)

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“…Indeed, mouse strains are known to vary dramatically in susceptibility to L . monocytogenes infection 38, and the basis for this remains largely unexplored. It is possible that complex genetic factors that influence infectious disease susceptibility can affect the magnitude of T cell responses.…”

Section: Discussionmentioning

confidence: 99%

H2-M3–Restricted T Cells in Bacterial Infection

Kerksiek

Busch

Pilip

et al. 1999

The Journal of Experimental Medicine

116

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Major histocompatibility complex (MHC) class Ib molecules have been implicated in CD8+ T cell–mediated defenses against intracellular bacterial infection, but the relative importance of MHC class Ib–restricted T cells in antimicrobial immunity is unknown. In this report, we use MHC tetramers to characterize T cell responses restricted by H2-M3, an MHC class Ib molecule that selectively presents N-formyl peptides. We find that sizeable H2-M3–restricted T cell responses, occurring earlier than MHC class Ia–restricted T cell responses, are mounted after primary infection with the intracellular bacterium Listeria monocytogenes. These H2-M3–restricted T cells are cytolytic and produce interferon γ. However, after a second L. monocytogenes infection, H2-M3–restricted memory T cell responses are minor in comparison to the much larger MHC class Ia–restricted responses. This first direct characterization of an MHC class Ib–restricted T cell response indicates that CD8+ T cells responding to L. monocytogenes infection can be divided into two groups: H2-M3–restricted responses, which provide rapid and quantitatively substantial effector function during primary infections but contribute relatively little to memory responses, and MHC class Ia–restricted responses, which expand later during primary infection but form memory T cells that respond rapidly and dramatically in response to subsequent infections by the same pathogen.

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Section: Discussionmentioning

confidence: 99%

H2-M3–Restricted T Cells in Bacterial Infection

Kerksiek

Busch

Pilip

et al. 1999

The Journal of Experimental Medicine

116

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“…The resistance to L. monocytogenes is a cellmediated immune function. The ability of a host to clear L. monocytogenes starts by day 3 and is fully developed by day 5 after infection (3). The preimmune (before day 3 after infection) macrophage phagocytic and bactericidal activities have been associated with the early resistance of mice to L. monocytogenes infections (29).…”

Section: Discussionmentioning

confidence: 99%

“…enced decreases in the number of CFU per liver and spleen. This clearance was probably due to the development of cell-mediated immunity against L. monocytogenes, which has been shown to develop at about day 5 after injection (3). The surviving mice fed the leucine-limited diet had significantly lower numbers of CFU per liver and spleen than the mice fed the control diet.…”

Section: Infect Immunmentioning

confidence: 95%

Effect of Dietary Essential Amino Acid Limitations upon the Susceptibility to Salmonella typhimurium and the Effect Upon Humoral and Cellular Immune Responses in Mice

Petro

Bhattacharjee

1981

Infect Immun

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We investigated the effects of dietary essential amino acid limitations on the susceptibility of mice to Salmonella typhimurium infections and on humoral and cellular immune (cell-mediated immune) responses of mice. Mice fed synthetic diets limited (significantly less than optimum concentration) in a single essential amino acid (leucine, isoleucine, valine, or lysine) for 3 weeks after they were weaned exhibited significantly enhanced susceptibility to S. typhimurium infection, as evidenced by the higher levels of mortality and spread of the bacterial cells in their livers and spleens compared with mice fed the control diet. Compared with mice fed the control diet, mice fed the diet limited in leucine had a lower ability to clear S. typhimurium cells from the peritoneal cavity 5 min after intraperitoneal injection, whereas mice fed the diet limited in lysine had a greater ability. The in vivo phagocytosis and in vitro bactericidal kinetics against S. typhimurium cells by peritoneal macrophages were not significantly different in the control group and the groups of mice fed experimental diets. Certain experimental groups exhibited significantly lower resistance and antibody response against S. typhimurium SL3770 on day 5 after immunization with heat-killed S. typhimurium SL3770. On day 8 after immunization, the levels of serum antibody against S. typhimurium in the mice fed the experimental diets were comparable to the levels in mice fed the control diet. However, the levels of serum transferrin and complement C3 were significantly lower in mice fed certain experimental diets. The cellular immune capacities of mice fed any of the experimental diets were not impaired compared with the capacities of mice fed the control diet, as measured by spleen cell responsiveness to phytohemagglutinin and the ability to clear infecting Listeria monocytogenes cells from livers and spleens.

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“…Once bacterial numbers become overwhelming, activation of T cells to produce IFN-γ no longer saves the mice. 23 At the very least, these experiments demonstrate that cytokine-expressing viruses could be used to elucidate the role of cytokines in immunity to experimental infections. At best, they suggest a role for such delivery systems in immunotherapy of clinical infection, especially where there is reason to believe a cytokine deficiency may be operating.…”

Section: Figurementioning

confidence: 96%

“…Following i.v. injection, 90% of Listeria organisms localize in the liver 23 and less than 5% in spleen and lungs, but subsequent growth of the bacteria is most rapid in the spleen. On day 7 (4 days after Listeria infection) bacterial counts were made on the liver and spleen, with the results shown in Table 1.…”

Section: Effects Of Pretreatment With Vaccinia Virus Constructs Exprementioning

confidence: 99%

Use of recombinant viruses to deliver cytokines influencing the course of experimental bacterial infection

et al. 1999

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SummaryThe feasibility of using viral constructs expressing cytokine genes to influence the course of bacterial infection was tested in mice. The mice were first infected with vaccinia or fowlpox viruses expressing the cytokine of interest, then challenged with the facultative intracellular bacterial pathogen Listeria monocytogenes. The course of infection was assessed by subsequent bacterial counts. Expression of IFN-γ or TNF was protective. Vaccinia virus was more efficient at delivering IFN-γ-mediated protection than was fowlpox virus, which is unable to proliferate in mammalian cells. The effect of vaccinia-IFN-γ was more apparent in the liver, where vaccinia proliferates to high titres (> 10 9 ), than in the spleen, where only 10 3 vaccinia were isolated. Vaccinia virus expressing IL-4 exacerbated infection. Interleukin-4 exacerbation was T cell independent and was reflected in the failure of macrophage activation, possibly due to suppression of NK cells, which are a source of IFN-γ early in infection. The clear indication of protection by some cytokines in this prophylactic model appears to justify further study of the therapeutic effects of cytokine-expressing viruses in chronic bacterial infections, especially where a cytokine defect is suspected.

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Resistance and susceptibility of mice to bacterial infection: course of listeriosis in resistant or susceptible mice

Cited by 119 publications

References 15 publications

H2-M3–Restricted T Cells in Bacterial Infection

H2-M3–Restricted T Cells in Bacterial Infection

Effect of Dietary Essential Amino Acid Limitations upon the Susceptibility to Salmonella typhimurium and the Effect Upon Humoral and Cellular Immune Responses in Mice

Use of recombinant viruses to deliver cytokines influencing the course of experimental bacterial infection

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