Resistance against two lytic phage variants attenuates virulence and antibiotic resistance in Pseudomonas aeruginosa
Juan Carlos García-Cruz,
Xareni Rebollar-Juarez,
Aldo Limones-Martinez
et al.
Abstract:BackgroundBacteriophage therapy is becoming part of mainstream Western medicine since antibiotics of clinical use tend to fail. It involves applying lytic bacteriophages that self-replicate and induce cell lysis, thus killing their hosts. Nevertheless, bacterial killing promotes the selection of resistant clones which sometimes may exhibit a decrease in bacterial virulence or antibiotic resistance.MethodsIn this work, we studied the Pseudomonas aeruginosa lytic phage φDCL-PA6 and its variant φDCL-PA6α. Additio… Show more
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