Resins-based denture soft lining materials modified by chlorhexidine salt incorporation: An in vitro analysis of antifungal activity, drug release and hardness

Bertolini, Martinna; Portela, Maristela Barbosa; Curvelo, José Alexandre Da Rocha; Soares, R. Félix; Lourenço, Eduardo José Veras; Telles, Daniel de Moraes

doi:10.1016/j.dental.2014.05.004

Cited by 60 publications

(35 citation statements)

References 31 publications

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“…PET and PMMA have been widely used for dental treatment in prosthodontics, orthodontics, oral surgery, and temporomandibular joint clinics. The introduction of these materials for use in the oral cavity provides more surfaces for bacterial adhesion and alters biofilm distribution when compared with non‐appliance wearers, leading to many biofilm‐related side effects (Rego et al ., ; Schaefer and Braumann, ; Bertolini et al ., ). Thus, the microbial implications of the two materials are of clinical importance.…”

Section: Discussionmentioning

confidence: 97%

“…Rougher surfaces usually attract more bacterial adhesion (Taylor et al ., ; Kawai et al ., ; Mei et al ., ,, ); however, the PMMA surfaces, which were rougher and more hydrophobic in the study, had less bacterial adhesion than the PET surfaces. This might due to the different chemical composition and functional groups of the two materials (Goldberg and Burstone, ; Zhang et al ., ; Gautam et al ., ; Etxeberria et al ., ; Bertolini et al ., ; Zafar and Ahmed, ). Further studies on the cause of this difference are needed.…”

Section: Discussionmentioning

confidence: 99%

“…PMMA is a rigid polymeric material, which was first introduced by Walter Wright in 1937 (John et al ., ). The desirable attributes of this traditional material includes low cost, high biocompatibility, easy handling and processing, make it still be commonly used in dentistry, for example, fabricating complete dentures, removable partial dentures, various maxillary expansion appliances, as well as orthodontic appliances and retainers (Gautam et al ., ; Zafar and Ahmed, ; Bertolini et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…Poly(ethylene terephthalate) (PET), a semicrystalline polymeric material, and Poly(methyl methacrylate) (PMMA), an atactic polymer of high average molecular weight, are both widely used for engineering dental applications, such as splints, retainers, and removable appliances (Goldberg and Burstone, ; Zhang et al ., ; Gautam et al ., ; Bertolini et al ., ; Zafar and Ahmed, ). PET is a transparent thermoplastic material, which is becoming increasingly popular in dentistry due to its aesthetics and ductility.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of bacterial adhesion to dental materials of polyethylene terephthalate (PET) and polymethyl methacrylate (PMMA) using atomic force microscopy and scanning electron microscopy

Fang

Wang

et al. 2016

Scanning

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The aim of this study was to compare the bacterial adhesion to denture materials of polyethylene terephthalate (PET) and polymethyl methacrylate (PMMA) using atomic force microscopy and scanning electron microscopy. The adhesion forces of living Streptococcus sanguinis and Streptococcus mutans to PET and PMMA were directly measured using atomic force microscopy (AFM) in liquid. Streptococcal biofilms formed on the two material surfaces were investigated and compared using scanning electron microscopy (SEM) and colony-forming units (CFU) counting. Surface roughness and hydrophobicity of PET and PMMA were also measured. The results showed that PET surfaces were significantly smoother and more hydrophilic than PMMA surfaces both with and without a salivary film (p < 0.01). The adhesion forces of S. sanguinis and S. mutans to PET surfaces were significantly stronger than to PMMA surfaces in the absence of a salivary film (p < 0.01). In the presence of a salivary film, the adhesion forces of both bacterial strains to PET and PMMA were significantly decreased (p < 0.01). The adhesion forces of S. mutans to PET surfaces (0.14 nN) were still significantly stronger than to PMMA surfaces (0.09 nN) (p < 0.01). The biofilm formed on PET surfaces was also significantly denser and more than on PMMA surfaces (p < 0.05). In conclusion, the bacterial adhesion to PMMA was significantly less in comparison with PET. PMMA may be preferable for patients who have poor oral hygiene, caries susceptibility, periodontosis, and halitosis. SCANNING 38:665-670, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of bacterial adhesion to dental materials of polyethylene terephthalate (PET) and polymethyl methacrylate (PMMA) using atomic force microscopy and scanning electron microscopy

Fang

Wang

et al. 2016

Scanning

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“…Candidiasis is often asymptomatic or may cause some discomfort for the patient, such as stinging, burning, and even pain 15,25 . In the present study, most people reported no symptoms.…”

Section: Discussionmentioning

confidence: 99%

A single-center 18-year experience with oral candidiasis in Brazil: a retrospective study of 1,534 cases

et al. 2018

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Despite the large number of published studies about oral candidiasis and associated risk factors, reports of large single-center retrospective studies on the prevalence of oral candidiasis, risk factors, and the oral candidiasis types diagnosed more frequently in oral diagnostic reference centers are scarce. The objective of the present study was to retrospectively survey the demographic and clinical profiles of 1,534 patients diagnosed with candidiasis and treated at the Center for Diagnosis of Oral Diseases (CDOD), Pelotas Dental School, Federal University of Pelotas between 1997 and 2014. Using a retrospective, cross-sectional, epidemiological design, data on race, gender, age, systemic diseases, oral candidiasis type and location, symptoms, and harmful habits such as smoking and alcohol consumption were collected. The statistical analysis was performed using STATA version 13.1. Risk factors for chronic atrophic candidiasis (CAC) were evaluated using Poisson regression with robust variance (p ≤ 0.05). The majority of patients with oral candidiasis seen at the CDOD over the 18-year period of analysis were Caucasian women, aged 51-60 years, nonsmokers, and nondrinkers, with no systemic disease, and who wore some form of dental prostheses. CAC was the single most common clinical type of candidiasis detected, and the most frequently affected oral site was the palate. These data from a large single-center in Brazil agree with previous evidence about the clinical and demographic profiles of patients with oral candidiasis.

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Effects of a biomimetic analog‐based experimental bonding system on caries‐affected and sound dentin

Gomes

Rossi

Silva

et al. 2020

Microscopy Res & Technique

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This study compared the ultrastructure, chemical composition, and proteases activity (PA) of sound (SD) and caries-affected dentin (CAD) in the dentin hybrid layer after using an experimental bonding system containing pyromellitic dianhydride glycerol methacrylate and biomimetic analogs. The bonding system used a three step and a total-etch procedure. Polyacrylic acid (5%) and sodium trimetaphosphate (5%) were added to the primer and monocalcium phosphate monohydrate (9%), beta-tricalcium phosphate (10.5%), and calcium hydroxide (0.5%) were added to the adhesive. Transmission electron microscopy (TEM) was used to evaluate the resultant structure, particularly the adhesive-dentin and the demineralized-SD interfaces. The chemical composition was evaluated through energy-dispersive X-ray spectroscopy (EDS) and selected area electron diffraction (SAED). The PA was measured with the Coomassie Blue-G250 coloring test, and the PA data were analyzed by ANOVA. EDS identified the presence of isolated calcium phosphate nanoparticles in the demineralized region; however, the SAED analysis did not show any evidences of hydroxyapatite (HA) neoformation in SD and CAD. The biomimetic analog-based adhesive system inhibited the activities of dentin proteases immediately after treatment. Additionally, the proteolytic activity on the affected dentin resembled that of the SD. In conclusion, no HA formed in the demineralized SD and CAD although there were calcium and phosphate deposits. The experimental adhesive system inhibited dentin proteases. • The present study uses a new approach to investigate the hybrid layer behavior in dentin. • The experimental adhesive system was synthesized and used on sound and affected-caries dentin as the substrate to reproduce real clinical conditions.

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Resins-based denture soft lining materials modified by chlorhexidine salt incorporation: An in vitro analysis of antifungal activity, drug release and hardness

Cited by 60 publications

References 31 publications

Comparison of bacterial adhesion to dental materials of polyethylene terephthalate (PET) and polymethyl methacrylate (PMMA) using atomic force microscopy and scanning electron microscopy

Comparison of bacterial adhesion to dental materials of polyethylene terephthalate (PET) and polymethyl methacrylate (PMMA) using atomic force microscopy and scanning electron microscopy

A single-center 18-year experience with oral candidiasis in Brazil: a retrospective study of 1,534 cases

Effects of a biomimetic analog‐based experimental bonding system on caries‐affected and sound dentin

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