Resilient liner modified by antimicrobials for denture stomatitis treatment: A randomized controlled trial

Procópio, Antônio Sílvio Fontão; Lara, Vanessa Soares; Porto, Vinícius Carvalho; Soares, Simone; Fernandes, María Helena; Urban, Vanessa Migliorini; Neppelenbroek, Karin Hermana

doi:10.1016/j.jdent.2022.104297

Cited by 5 publications

(7 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Badaró et al (2020) [ 52 ] reported an RCT that showed an efficacy of 0.25% sodium hypochlorite as a disinfectant for denture cleaning. Finally, Procópio et al (2022) [ 53 ] reported on the benefits of incorporating minimum inhibitory concentrations of antimicrobials (nystatin or chlorhexidine diacetate) in denture liners.…”

Section: Resultsmentioning

confidence: 99%

Management of Chronic Atrophic Candidiasis (Denture Stomatitis)—A Narrative Review

Abuhajar

Ali

Zulfiqar

et al. 2023

IJERPH

View full text Add to dashboard Cite

One of the most common oral diseases affecting people wearing dentures is chronic atrophic candidiasis or denture stomatitis (DS). The aim of the paper is to provide an update on the pathogenesis, presentation, and management of DS in general dental practice settings. A comprehensive review of the literature published in the last ten years was undertaken using multiple databases, including PubMed via MEDLINE, EMBASE, and Scopus. The eligible articles were analyzed to identify evidence-based strategies for the management of DS. Despite its multifactorial nature, the leading cause of DS is the development of oral Candida albicans biofilm, which is facilitated by poor oral and denture hygiene, long-term denture wear, ill-fitting dentures, and the porosity of the acrylic resin in the dentures. DS affects between 17 and 75% of the population wearing dentures, with a slight predominance in elderly females. The mucosal denture surfaces and posterior tongue are the common sites of DS, and the affected areas exhibit erythema, the swelling of the palatal mucosa and edema. Oral and denture hygiene protocols, adjusting or re-fabricating poorly adapting dentures, smoking cessation, avoiding nocturnal denture wear, and the administration of topical or systemic antifungals are the mainstay of management. Alternate treatments such as microwave disinfection, phytomedicine, photodynamic therapy, and incorporation of antifungals and nanoparticles into denture resins are being evaluated for the treatment of DS but require further evidence before routine use in clinical practice. In summary, DS is the most common oral inflammatory lesion experienced by denture wearers. Most patients with DS can be managed in general dental practice settings. Effective management by general dental practitioners may be supported by a thorough understanding of the pathogenesis, the recognition of the clinical presentation, and an awareness of contemporary treatment strategies.

show abstract

Section: Resultsmentioning

confidence: 99%

Management of Chronic Atrophic Candidiasis (Denture Stomatitis)—A Narrative Review

Abuhajar

Ali

Zulfiqar

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…After written consent had been obtained, the medical records of the selected participants were investigated regarding the general risk factors involved with microbial colonization of MCD and, therefore, with denture biofilm: age, sex, diagnostic hypothesis, hospitalization time, and use of antibiotics, antifungals, and steroids. 16 For antibiotics and antifungals, the type (salt name) and day of treatment when the biofilm was collected for this study were recorded. Moreover, two local risk factors related to the density of the denture biofilm and the prevalence of oral infections were considered in this RCT: denture age and nocturnal denture wear.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, two local risk factors related to the density of the denture biofilm and the prevalence of oral infections were considered in this RCT: denture age and nocturnal denture wear. 6 , 16 …”

Section: Methodsmentioning

confidence: 99%

“…Microbiological samples were obtained by vigorously rubbing sterile oral swabs on the intaglio surface of the MCD for 1 min. 16 Each swab was placed in a test tube containing 5 mL of 0.9% sterile saline. Next, to detach the collected material from the swabs, the tubes were placed in a tube holder inside an ultrasonic cleaning tank (Cristófoli, Campo Mourão, PR, Brazil) with cold water (6 to 10ºC) and were ultrasonicated for 20 min.…”

Section: Methodsmentioning

confidence: 99%

“… 8 Despite these favorable data obtained with the removal of dental biofilm, information on cleaning protocols for removable dentures in hospitalized patients is lacking, and most users still clean their dentures by simply rinsing them in water or brushing them with toothpaste, soap or even water because it is easy, simple, and inexpensive. 10 However, when used alone, brushing has poor effectiveness in removing denture biofilm, 11 - 16 especially when performed by older individuals with compromised manual dexterity and visual acuity. 10 To overcome these limitations, brushing should be combined with microwave irradiation or immersion in chemical cleaning agents.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-biofilm effectiveness of protocols for cleaning complete dentures in hospitalized patients: a randomized controlled trial

GOMES,

MACIEL,

GARCIA

et al. 2024

J. Appl. Oral Sci.

Self Cite

View full text Add to dashboard Cite

Denture biofilm acts as a potential reservoir for respiratory pathogens, considerably increasing the risk of lung infections, specifically aspiration pneumonia, mainly 48h after hospital admission. The establishment of a straightforward, affordable, and applicable hygiene protocol in a hospital environment for the effective control of denture biofilm can be particularly useful to prevent respiratory infections or reduce the course of established lung disease. Objectives To evaluate the anti-biofilm effectiveness of denture cleaning protocols in hospitalized patients. Methodology The maxillary complete dentures (MCDs) of 340 hospitalized participants were randomly cleaned once using one of the following 17 protocols (n=20): brushing with distilled water, toothpaste, or neutral liquid soap (controls); immersion in chemical solutions (1% sodium hypochlorite, alkaline peroxide, 0.12% or 2% chlorhexidine digluconate), or microwave irradiation (650 W for 3 min) combined or not with brushing. Before and after the application of the protocols, the biofilm of the intaglio surface of the MCDs was evaluated using two methods: denture biofilm coverage area (%) and microbiological quantitative cultures on blood agar and Sabouraud Dextrose Agar (CFU/mL). Data were subjected to the Wilcoxon and Kruskal-Wallis tests (α=0.05). Results All 17 protocols significantly reduced the percentage area of denture biofilm and microbial and fungal load ( P <0.05). The highest percentage reductions in the area of denture biofilm were observed for 1% hypochlorite solution with or without brushing and for 2% chlorhexidine solution and microwave irradiation only in association with brushing ( P <0.05). The greatest reductions in microbial and fungal load were found for the groups that used solutions of 2% chlorhexidine and 1% hypochlorite and microwave irradiation, regardless of the association with brushing (P<0.05). Conclusions A single immersion for 10 min in 1% sodium hypochlorite, even in the absence of brushing, proved to be a straightforward, rapid, low-cost, and effective protocol for cleaning the dentures of hospitalized patients.

show abstract

Losartan Plays a Fungistatic and Fungicidal Activity Against Candida albicans Biofilms: Drug Repurposing for Localized Candidosis

Lara

Silva

Ferrari

et al. 2023

ASSAY and Drug Development Technologies

View full text Add to dashboard Cite

Resilient liner modified by antimicrobials for denture stomatitis treatment: A randomized controlled trial

Cited by 5 publications

References 28 publications

Management of Chronic Atrophic Candidiasis (Denture Stomatitis)—A Narrative Review

Management of Chronic Atrophic Candidiasis (Denture Stomatitis)—A Narrative Review

Anti-biofilm effectiveness of protocols for cleaning complete dentures in hospitalized patients: a randomized controlled trial

Losartan Plays a Fungistatic and Fungicidal Activity Against Candida albicans Biofilms: Drug Repurposing for Localized Candidosis

Contact Info

Product

Resources

About