Abstract:A myriad of pathological changes associated with epilepsy can be recast as decreases in cell and circuit heterogeneity. We propose that epileptogenesis can be recontextualized as a process where reduction in cellular heterogeneity renders neural circuits less resilient to transitions into information-poor, over-correlated seizure states. We provide in vitro, in silico, and mathematical support for this hypothesis. Patch clamp recordings from human layer 5 (L5) cortical neurons demonstrate significantly decreas… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.