Under the influence of global climate change, urban flood and drought disasters occur frequently, so that is extremely important to construct the resilience capacity of urban water supply system. Based on the framework of system toughness and capability analysis, using correlation analysis and factor analysis to construct the index system of resilience capacity assessment of urban water supply system, which reflects the four dimensions of water source, water plants, water supply and distribution network and users, and five dimensions of social, natural environment, economy, physics and organization, and the weights of all indexes are given. The multi-level comprehensive evaluation model based on cloud model and the index comprehensive evaluation index method based on entropy weight were used to evaluate the resilience of the water supply system in Qingdao under flood and drought disasters, and the evaluation results of the two methods were compared. Finally, based on the evaluation results, the influencing factors of water supply system resilience were analyzed, and the corresponding strategies to improve the resilience of water supply system were proposed, in order to provide decision support for the planning and construction of urban water supply system resilience in the near and long term.