Residues of zearalenone (ZEN), deoxynivalenol (DON) and their metabolites in plasma of dairy cows fed Fusarium contaminated maize and their relationships to performance parameters

Winkler, Janine; Kersten, Susanne; Meyer, Ulrich; Engelhardt, Ulrich H.; Dänicke, Sven

doi:10.1016/j.fct.2013.12.020

Cited by 62 publications

(62 citation statements)

References 31 publications

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“…These data complete the results on the general effects of dietary treatments on performance traits and mycotoxin residue levels in various matrices as reported recently (Winkler et al 2014a, Winkler et al 2014b, Winkler et al 2015a, Winkler et al 2015b). The second aim was to relate the health- and immune-related characteristics investigated in the present study to the performance, the energy status and to mycotoxin residue levels reported recently (Winkler et al 2014a) in order to obtain a more comprehensive view on the consequences of feeding diets contaminated with DON and ZEN on the physiological sensitive early lactating dairy cow.…”

Section: Introductionsupporting

confidence: 87%

Haematological, clinical–chemical and immunological consequences of feeding Fusarium toxin contaminated diets to early lactating dairy cows

et al. 2016

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Dairy cows experience a negative energy balance at the onset of lactation which results in an enhanced vulnerability for infectious diseases. Any dietary imbalances, including Fusarium toxin contamination, might therefore exacerbate this situation. The aim of the present investigations was to study the effects of increasing dietary concentrations of deoxynivalenol (DON) and zearalenone (ZEN) on clinical-chemical, haematological and immunological traits up to week 14 of lactation. For this purpose, ten cows each were assigned to a control group (CON; 0.02 mg ZEN and 0.06 mg DON per kg diet at 88 % DM), toxin level 1 (TOX-1; 0.29 mg ZEN and 2.31 mg DON per kg diet at 88 % DM) and toxin level 2 (TOX-2; 0.58 mg ZEN and 4.61 mg DON per kg diet at 88 % DM). The measured values of most parameters were affected by parturition but only a few of them were further modified by dietary treatment. For example, the time-dependent decrease in haemoglobin concentration, haematocrit and erythrocyte counts occurred at a significantly higher level for group TOX-2 while a serum glucose increase was missing in this group. Proportions of CD4+ and CD8+ cells decreased significantly over time solely in group TOX-2 while the CD4+/CD8+ ratio remained uninfluenced. Ability of granulocytes to mount an oxidative burst tended to increase at the end of the study in groups TOX-1 and TOX-2 while the opposite was observed in group CON. The results of this time-limited study indicate that feeding of Fusarium-toxin contaminated diets in early lactation affects health related parameters without compromising milking performance. However, long-term consequences of the observed effects on health need to be addressed in further studies.

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Section: Introductionsupporting

confidence: 87%

Haematological, clinical–chemical and immunological consequences of feeding Fusarium toxin contaminated diets to early lactating dairy cows

et al. 2016

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“…According to Korosteleva et al (2007) milk composition was not affected by a diet containing DON. Similar findings were reported for DON + ZEA (Winkler et al, 2014) or AFL (Xiong et al, 2015). Kiyothong et al (2012) did not find significant differences in fat, lactose, and solids-non-fat after supplementation of MSAs to multi-mycotoxin (DON, FB1, ZEA, OTA, AFL, and T-2 toxin) contaminated diet, but they reported a positive influence of MSAs on milk protein concentration (P < 0.05) and also noted that milk fat percentage tended to be higher for MSA-supplemented than for non-supplemented cows.…”

Section: Effect Of Mycotoxin Load On Basic Milk Indicatorssupporting

confidence: 78%

“…Yoshizawa et al, 1981) or two mycotoxins (DON + ZEA -e.g. Winkler et al, 2014;Korosteleva et al, 2007). However, experimental conditions differ from farm conditions where animals may be exposed to a mycotoxin "cocktail" as documented in recent studies describing natural multi-mycotoxin contamination of feedstuffs (Hofstetter and Rodrigues, 2009;Kiyothong et al, 2012;Zachariášová et al, 2014).…”

Section: General Description Of Datasetmentioning

confidence: 99%

Chemical, physical and technological properties of milk as affected by the mycotoxin load of dairy herds

Křížová

Hanuš²,

Klimešová³

et al. 2016

Arch. Anim. Breed.

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Abstract. The aim of the study was to determine the impacts of different levels of mycotoxin load of Czech dairy herds on the larger scale of the milk indicators including milk physical and technological properties. During three subsequent years individual milk samples (IMSs) were collected from four herds of Czech Fleckvieh (C) and from four herds of Holstein cows (H). The IMSs were collected regularly twice in summer and twice in winter, resulting in a total of 936 IMSs. The feeding rations consisted mainly of conserved roughage and supplemental mixtures according to milk yield and standard demands. Samples of feedstuffs were collected at the same time as IMSs and were analysed for content of deoxynivalenol (DON), fumonisins (FUM), zearalenone (ZEA), aflatoxin (AFL), and T-2 toxin using enzyme-linked immunosorbent assay (ELISA) methods. Based on the mycotoxin load, herds were divided into three groups -Load 1 (negligible, n = 36), Load 2 (low, n = 192), and Load 3 (medium, n = 708). All feedstuff samples were positive for at least one mycotoxin. The most frequently occurring mycotoxins were FUM, DON, and ZEA. Relatively high incidence of AFL (56 % positive samples) was observed. The following milk indicators were influenced by the mycotoxin load of herds: fat, acetone (Ac), log Ac, pH, electric conductivity, alcohol stability, curds quality, curd firmness, whey volume, whey protein, non-protein nitrogen (NPN), urea N in NPN, fat / crude protein ratio, and casein numbers on crude and true protein basis, respectively (P < 0.05). The overall level of mycotoxin load was relatively low, with no clear effect on milk characteristics.

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“…Depending on the specimen and sample preparation, LOD of ZEN and its metabolites varied between 0.01 ng/mL and 0.71 ng/mL for blood plasma (Brezina et al, 2014b;Devreese et al, 2012;Winkler et al, 2014a), between 0.1 ng/g and 3 ng/g for tissue samples (Jodlbauer et al, 2000;Z€ ollner et al, 2002), between 0.1 ng/mL and 1 ng/mL for urine (Jodlbauer et al, 2000;Song et al, 2013;Songsermsakul et al, 2006), between 0.01 ng/mL and 0.02 ng/mL for follicular fluid (Takagi et al, 2008) and between 0.02 ng/mL and 0.06 ng/mL for bovine milk (Sørensen and Elbaek, 2005).…”

Section: Milk Excretionmentioning

confidence: 99%

Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over)

Dänicke

Winkler

2015

Food and Chemical Toxicology

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Residues of zearalenone (ZEN), deoxynivalenol (DON) and their metabolites in plasma of dairy cows fed Fusarium contaminated maize and their relationships to performance parameters

Cited by 62 publications

References 31 publications

Haematological, clinical–chemical and immunological consequences of feeding Fusarium toxin contaminated diets to early lactating dairy cows

Haematological, clinical–chemical and immunological consequences of feeding Fusarium toxin contaminated diets to early lactating dairy cows

Chemical, physical and technological properties of milk as affected by the mycotoxin load of dairy herds

Invited review: Diagnosis of zearalenone (ZEN) exposure of farm animals and transfer of its residues into edible tissues (carry over)

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