Residues of Endosulfan in Meat and Milk of Cattle Fed Treated Forages12

Beck, E. W.; Johnson, Joyce; Woodham, D. W.; Leuck, D. B.; Dawsey, L. H.; Robbins, John E.; Bowman, M. C.

doi:10.1093/jee/59.6.1444

Cited by 20 publications

(14 citation statements)

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“…Endosulfan diol is a non-toxic metabolite to fish and other organisms. It can be further degraded to non-toxic endosulfan ether, endosulfan hydroxyether and endosulfan lactone; thus, production of endosulfan diol via hydrolysis may be an important detoxification pathway of endosulfan [9,19]. Some investigators have reported that the toxicity of endosulfan residues and the metabolites formed after degradation was evaluated by the mortality of the test organisms Tubifex tubifex [16], by yeast-based cell growth inhibition [14] and by the frequency of micronucleus (MN) emergence in polymorphonuclear leukocyte cells [13].…”

Section: Introductionmentioning

confidence: 99%

Biodegradation and detoxification of endosulfan in aqueous medium and soil by Achromobacter xylosoxidans strain CS5

Wen

Dai

Xue

et al. 2009

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 99%

Biodegradation and detoxification of endosulfan in aqueous medium and soil by Achromobacter xylosoxidans strain CS5

Wen

Dai

Xue

et al. 2009

Journal of Hazardous Materials

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“…Metabolism studies have shown that the toxic metabolite endosulphate is the major residue detected in soils, and in plant and animal tissues after exposure to endosulfan (Beck et al . 1966; Maier‐Bode 1968; Beard and Ware 1969; Stewart and Cairns 1974; Dorough et al .…”

Section: Introductionmentioning

confidence: 99%

“…1998). Unlike the parent compounds, which have relatively low persistence and do not bioaccumulate, endosulphate persists in soils and sediments and accumulates in animal fat (Beck et al . 1966; Maier‐Bode 1968; Dorough et al .…”

Section: Introductionmentioning

confidence: 99%

Enrichment of a microbial culture capable of degrading endosulphate, the toxic metabolite of endosulfan

et al. 2002

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Aims: The aim of this study was to isolate a source of enzymes capable of degrading endosulphate (endosulfan sulphate), the toxic metabolite of the pesticide endosulfan. Methods and Results: A microbial broth culture capable of degrading endosulphate was enriched from endosulfan-contaminated soil by providing the metabolite as the sole source of sulphur in broth culture. No microbial growth was observed in the absence of endosulphate. In the presence of endosulphate, growth of the culture occurred with the concomitant formation of three chlorine-containing compounds. Thin layer chromatography and gas chromatography±mass spectral analysis identi®ed these metabolites as endosulfan monoaldehyde, 1,2,3,4,7,7-hexachloro-5,6-bis(methylene)bicyclo[2.2.1]-2-heptene and 1,2,3,4,7,7-hexachloro-5-hydroxymethylene-6-methylenebicyclo[2.2.1]-2-heptene. The second and third compounds have not been reported in previous metabolic studies. The enriched culture was also able to utilize a-and b-endosulfan as sulphur sources, each producing the hydrolysis product endosulfan monoaldehyde as the sole chlorine-containing metabolite. Alpha-endosulfan was more readily hydrolysed than the b-isomer. Conclusions: This study isolated a mixed microbial culture capable of degrading endosulphate. The products of degradation were characterized as novel endosulfan metabolites. Signi®cance and Impact of the Study: This study describes the isolation of a mixed microbial culture that is potentially a valuable source of hydrolysing enzymes for use in enzymatic bioremediation, particularly of endosulphate and a-endosulfan residues.

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“…[40][41][42] Unlike the isomers of endosulfan, the lipophilic metabolite endosulfate can accumulate in animal fat. 1,43,44 As a result, pasture contamination can result in unacceptably high endosulfate residues in locally grown production animals. Endosulfan present at trace levels in air and total atmospheric precipitations of Paris was found by Trajkovska et al 45 About its distribution predicate fact, endosulfan was also found in the eggs of broad-snouted caimans (Caiman latirostris), thus caiman eggs could be useful to biomonitor local contamination by endosulfan.…”

Section: Environmental Toxicologymentioning

confidence: 99%

Clinical Aspects of the Poisoning by the Pesticide Endosulfan

Patočka¹,

Wu²,

França³

et al. 2016

Química Nova

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publicado na web em 06/06/2016 Endosulfan is an organochlorine insecticide, widely used in insect control. Unfortunately, it is also an acute neurotoxic compound to both insects and mammals, including humans, and has been responsible for many severe poisonings and several fatal cases. Endosulfan also imitates or enhances the effect of the female hormone estrogen, having the capability of causing reproductive and developmental damage in both, animals and humans, and its exposure has been linked to liver tissue injury. This persistent lipophilic compound is one of the most abundant organochlorine pesticides in the environment, capable of undergoing long range transport to remote locations such as the Arctic. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its indiscriminate and injudicious use in the control of insects on a wide range of agricultural products and in the extermination of household pests, has considerably increased the hazard risk for human health. Also, this compound has a high fatality rate in humans when ingested accidentally, from food or water contaminated, or in suicidal cases. The aim of this article is to review and summarize chemical, biochemical, environmental, and toxicological data of endosulfan and draw attention to its toxicological potential risk to human health.

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Residues of Endosulfan in Meat and Milk of Cattle Fed Treated Forages12

Cited by 20 publications

References 0 publications

Biodegradation and detoxification of endosulfan in aqueous medium and soil by Achromobacter xylosoxidans strain CS5

Biodegradation and detoxification of endosulfan in aqueous medium and soil by Achromobacter xylosoxidans strain CS5

Enrichment of a microbial culture capable of degrading endosulphate, the toxic metabolite of endosulfan

Clinical Aspects of the Poisoning by the Pesticide Endosulfan

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