Residues Neighboring an SH3-Binding Motif Participate in Determining Affinity and SpecificityIn Vivo
David F. Jordan,
Alexandre K. Dubé,
Ugo Dionne
et al.
Abstract:In signaling networks, many protein-protein interactions are mediated by modular domains that bind short linear motifs. The motifs' sequences modulate many factors, among them affinity and specificity, or the ability to bind strongly and to bind the appropriate partners. Previous studies have proposed a trade-off between affinity and specificity, suggesting that motifs with high affinity are less capable of differentiating between domains with similar sequences and structures. Using Deep Mutational Scanning to… Show more
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