Soil, water, and air quality can be positively impacted by alternative crop residue management practices that return residue to the soil. Double-crop production systems, particularly those with a grass included in the rotation, rely on successful residue management practices. Soil quality and overall soil tilth are often low in regions with a long history of intensely cultivated, row-crop production, such as in the Mississippi River Delta region of the mid-South. Therefore, the objective of this study was to evaluate the effects of alternative residue (i.e., tillage, residue burning, and residue level) and water management practices on soil properties, soybean [Glycine max (L.) Merr.] production, and net economic returns, over two consecutive rotations in a wheat (Triticum aestivum L.)-soybean double-crop system in the Mississippi River Delta region of eastern Arkansas. Initiated in 2001, this study reports results from years 4 and 5 of the experiment. Residue management effects were inconsistent among soil properties and years, and differences were generally agronomically non-significant. Averaged across irrigation treatments, soybean yield was unaffected by tillage, burning, and residue level either year. Within the non-irrigated treatment, conventionally tilled (CT) soybean yield was 38 % greater (p < .05) than no-tillage (NT) in 2005, but similar in 2006. In 2005 and 2006, irrigated soybean yield was 34 and 26 % greater (p < .05), respectively, in the burned than non-burned treatment. In 2006, the estimated net return from the high residue/burned/NT/irrigated Management Practice Effects on Soil and Crop Response 717treatment combination was 51 % greater than the traditional combination of high residue/burned/CT/irrigated soybean. By years four and five following conversion from CT to NT, the more environmentally sustainable practice of NT appears to be a viable, and potentially more profitable, alternative to the traditional and common practice of CT.