Residue levels of DDE and PCBs in the blood serum of women in the Port Said region of Egypt

Ahmed, Mohamed Tawfic; Loutfy, Naglaa; Shiekh, Einas El

doi:10.1016/s0304-3894(01)00283-7

Cited by 42 publications

(20 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four recent studies involving non-white or non-Western populations of women found significantly higher DDE levels among women with breast cancer (1,16,39,40). These populations of women live in countries where the use of DDT is not banned or has only recently been banned; therefore exposure is likely to be greater and on-going.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer among Alaska Native women potentially exposed to environmental organochlorine chemicals

Rubin

Lanier

Kieszak

et al. 2006

International Journal of Circumpolar Health

View full text Add to dashboard Cite

Objectives. To determine if an increased rate of breast cancer in Alaska Native women is related to their consumption of a subsistence diet that may contain p,p'-dichlorodiphenylethylene (DDE) and polychlorinated biphenyls (PCBs). Study Design. A retrospective case control design. Methods. We analyzed banked serum collected between 1981 and 1987 from 126 Alaska Native women, including 63 case women who subsequently developed breast cancer and 63 age-matched control women who remained cancer-free. Serum was analyzed for DDT, DDE, 13 other chlorinated pesticides, and 28 PCB congeners. Results. The geometric mean for p,p'-DDE levels among case women was 8.67 ppb (95% Confidence Interval 7.48, 10.04); among control women, the geometric mean was 7.36 ppb (6.53, 8.30). The geometric mean for total PCB levels among case women was 4.55 ppb (3.61, 5.74) and for control women, the geometric mean was 6.10 ppb (4.73, 7.86). Cancer status and total PCB levels varied across ethnicity (i.e., Eskimo, Aleut, and Indian) but DDE levels were uniform among these ethnic groups. Using conditional logistic regression analysis to adjust for potential confounders (e.g., ethnicity, family history of breast cancer, parity), we found an odds ratio of 1.43 (0.46, 4.47) for the highest tertile of DDE exposure and 0.42 (0.07, 2.38) for the highest tertile of total PCB exposure. Conclusions. Although the results are limited by small sample size and restricted risk factor information, our findings of higher DDE levels, but lower PCB levels among women with breast cancer are consistent with previous research. Our results confirm exposure to organochlorines among Alaska Native women but do not identify these exposures as a significant risk factor for breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Breast cancer among Alaska Native women potentially exposed to environmental organochlorine chemicals

Rubin

Lanier

Kieszak

et al. 2006

International Journal of Circumpolar Health

View full text Add to dashboard Cite

show abstract

“…Their high lipophilicity has resulted in bioaccumulation in various organisms through the food chain, and many PCB congeners have been detected in human blood, milk, and other tissues [1,2]. PCBs consist of up to 209 different congeners, and the biological effects and toxicity of individual congener greatly depend on its structure [3,4].…”

Section: Introductionmentioning

confidence: 99%

PCB congeners induced mitochondrial dysfunction in Vero cells

Shen¹,

Shen²,

Yu³

et al. 2011

Journal of Hazardous Materials

View full text Add to dashboard Cite

“…Their physical properties, such as thermal stability, low reactivity, and low electrical conductance, have made them extensively used in industries [1]. The high lipophilicity of PCB has resulted in their bioaccumulation in various organisms through the food chain, and many PCB congeners have been detected in human blood, milk, and other tissues [2]. PCBs were reported to be immunotoxic [3], carcinogenic [4] and neurotoxic [5], they were considered to be a present risk in both animals and humans [6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of structure-dependent hormetic cytotoxicity induced by coplanar and non-coplanar PCB congeners

Chen

Shen

et al. 2010

Journal of Hazardous Materials

View full text Add to dashboard Cite

Residue levels of DDE and PCBs in the blood serum of women in the Port Said region of Egypt

Cited by 42 publications

References 8 publications

Breast cancer among Alaska Native women potentially exposed to environmental organochlorine chemicals

Breast cancer among Alaska Native women potentially exposed to environmental organochlorine chemicals

PCB congeners induced mitochondrial dysfunction in Vero cells

Comparison of structure-dependent hormetic cytotoxicity induced by coplanar and non-coplanar PCB congeners

Contact Info

Product

Resources

About