Residual thromboxane activity and oxidative stress

Vasudevan, Anupama; Tecson, Kristen M.; Sathyamoorthy, Mohanakrishnan; Schussler, Jeffrey M.; Velasco, Carlos; Lopez, Luis R.; Swift, Caren; Peterson, Margarita; Bennett-Firmin, Jeanna; Schiffmann, Raphael; McCullough, Peter A.

doi:10.1097/mca.0000000000000461

Cited by 8 publications

(2 citation statements)

References 18 publications

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“…This is often used as the gold standard for evaluating the OS level in the body, which has been proven to be one of the independent risk factors of coronary heart disease. [23] Furthermore, the 8-iso-PGF 2α levels are significantly increased in patients with abdominal obesity and metabolic syndrome. [22,24] At 1 week after patients were treated with Roux-en-Y gastric bypass, the plasma level of 8-iso-PGF 2α decreased by more than 50%, while 8-iso-PGF 2α levels decreased by more than 1/3 in subcutaneous adipose tissues.…”

Section: Discussionmentioning

confidence: 99%

The correlation between oxidative stress level and intra-abdominal fat in obese males

Jia¹,

Liu

Tian³

et al. 2019

Medicine

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This study aims to investigate the correlation between oxidative stress and intra-abdominal fat (IAF) in obese young and middle-aged males. The present study included 136 male examinees in the Examination Center of the First Hospital of Qinhuangdao from October 10, 2015 to December 10, 2015. Then, clinical data, oxidative stress indices (8-iso-prostaglandin F 2α [8-iso-PGF 2α ], malondialdehyde [MDA], and superoxide dismutase [SOD]), and IAF area were recorded. All subjects were assigned into 3 groups according to body mass index (BMI): obese group (BMI ≥ 28 kg/m 2 , 43 subjects), overweight group (24 ≤ BMI < 28 kg/m 2 , 46 subjects), and control group (BMI < 24 kg/m 2 , 47 subjects). Then, statistical analysis was performed. There were significant differences in IAF area, leptin, adiponectin, 8-iso-PGF 2α , MDA, SOD, fasting insulin (FINS), fasting blood glucose (FBG), and homeostasis model assessment-insulin resistance (HOMA-IR) among these 3 groups ( P < .05). Male subjects in the obese group had higher leptin, 8-iso-PGF 2α , MDA, FINS, and HOMA-IR levels, compared to subjects in the overweight and control groups. Furthermore, subjects in the overweight group had a larger IAF area and higher 8-iso-PGF 2α , MDA, and FBG levels, when compared to controls. In addition, SOD was significantly lower in the obese and overweight groups than in the control group. However, there were no statistical differences in age, systolic and diastolic blood pressure, lipids, and islet β-cell secretion function (homeostasis model assessment-β) among these 3 groups ( P ≥ .05). Moreover, the IAF area was positively correlated to 8-iso-PGF 2α and MDA, and negatively correlated to SOD. Oxidative stress is significantly associated with the IAF area in obese males, and abdominal obesity could increase oxidative stress level and insulin resistance.

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Section: Discussionmentioning

confidence: 99%

The correlation between oxidative stress level and intra-abdominal fat in obese males

Jia¹,

Liu

Tian³

et al. 2019

Medicine

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“…Cardiovascular diseases are the most common cause of death in the world. 1 Coronary artery bypass (CABG) is one of the most common treatments for patients with coronary artery disease. According to the American Heart Association (AHA) in 2015, there are about 400,000 CABGs in the United States per year.…”

Section: Introductionmentioning

confidence: 99%

Modifying Stressors Using Betty Neuman System Modeling in Coronary Artery Bypass Graft: a Randomized Clinical Trial

2020

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Introduction: Coronary artery disease (CAD) is one of the major causes of mortality all over the world. In this relation, coronary artery bypass grafting (CABG) is one of the most important treatments for CAD patients. However, it leads to a lot of stress in the patient. The aim of this study was to use the Neuman model to moderate the stressors in patients undergoing coronary artery bypass graft. Methods: This study was a randomized clinical trial of two groups performed on patients admitted to the coronary artery bypass graft; and the study completed with 64 patients. The intervention was performed by the researcher according to the format of the Neuman Model, which included the investigation of the stressors, and the determination of the goals and strategies for the actions. Intrapersonal, interpersonal, and extra personal factors were evaluated using a Revised Cardiac Surgery Stressor Scale (RCSSS). The intervention program was designed by the researcher based on prevention levels using scientific resources. The collected data were analyzed in SPSS ver. 13 using descriptive and inferential statistics. Results: Before the intervention, the mean score of the stressors was not significantly different between the two groups. But immediately after the intervention and before discharging the intervention group, it was significantly less than the control group. Conclusion: Using a Neuman-based program as an effective and low-cost intervention can moderate the stressors and reduce the stress of patients awaiting coronary artery bypass graft. This theory can be a good guide to offering the roles needed to provide health services in the community.

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Association of aspirin resistance with 4‐hydroxynonenal and its impact on recurrent cerebral infarction in patients with acute cerebral infarction

et al. 2020

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Objectives To investigate the association of aspirin resistance (AR) with the plasma 4‐hydroxynonenal (4‐HNE) level and its impact on recurrent cerebral infarction (CI) in patients with acute cerebral infarction (ACI) who were receiving aspirin therapy. Methods One hundred and fifty‐four ACI patients who previously received aspirin therapy (100 mg/day) were enrolled. Whole urine (for measuring 11dhTXB2 and creatinine) along with blood (for measuring the plasma 4‐HNE level) were collected at least 7 days after the patients received aspirin. A cutoff of 1500 pg/mg of 11dhTXB2/ creatinine was used to determine AR. A follow‐up period to monitor recurrence CI events was 1 year. In addition, blood testing was performed when the patients were first admitted to hospital. Results Forty‐six of the 154 enrolled patients (29.9%) were found to be AR. No statistical difference in age, sex, hypertension, diabetes mellitus, coronary disease, smoking status, NIHSS score, TOAST classification, platelet count, thrombocytocrit, LDL‐C, HDL‐C, TG, and TC was found between the AR and aspirin‐sensitive (AS) patients, but the plasma 4‐HNE level was found to be higher in the AR patients than AS patients (p < .05). Multiple logistic regression analysis showed that the 4‐HNE level was associated with a higher risk of AR (OR = 1.034; 95% CI = 1.011–1.058; p < .05). Moreover, 1‐year follow‐up showed that AR was more prevalent in patients with recurrent CI (26 (56.6%)) than those without (20/(43.5%)) (p < .001). Conclusions The plasma 4‐HNE level is strongly associated with AR and thus may be a factor contributing to AR. Patients with AR have a greater risk of recurrence CI.

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Residual thromboxane activity and oxidative stress

Abstract: We found that 11dhTxB2 appears to be a better prognostic marker for mortality as compared with 8-IsoPGF2α, suggesting aspirin resistance itself is a stronger independent determinant of death in CAD patients treated with aspirin.

Cited by 8 publications

References 18 publications

The correlation between oxidative stress level and intra-abdominal fat in obese males

The correlation between oxidative stress level and intra-abdominal fat in obese males

Modifying Stressors Using Betty Neuman System Modeling in Coronary Artery Bypass Graft: a Randomized Clinical Trial

Association of aspirin resistance with 4‐hydroxynonenal and its impact on recurrent cerebral infarction in patients with acute cerebral infarction

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