Residual OXPHOS is required to drive primary and metastatic lung tumours in an orthotopic breast cancer model
Patries Herst,
Georgia Carson,
Danielle Lewthwaite
et al.
Abstract:BackgroundFast adaptation of glycolytic and mitochondrial energy pathways to changes in the tumour microenvironment is a hallmark of cancer. Purely glycolytic ρ0 tumour cells do not form primary tumours unless they acquire healthy mitochondria from their micro-environment. Here we explored the effects of severely compromised respiration on the metastatic capability of 4T1 mouse breast cancer cells.Methods4T1 cell lines with different levels of respiratory capacity were generated; the Seahorse extracellular flu… Show more
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