Residual kidney function after donor nephrectomy

Hamscho, N; Wilhelm, Albina; Döbert, Natascha; Menzel, C.; Goßmann, Jan; Berner, U; Zaplatnikov, K.; Scheuermann, Ernst; Grünwald, Frank

doi:10.1055/s-0038-1625206

Cited by 9 publications

(1 citation statement)

References 6 publications

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“…There are two possible explanations for this. First, in cases in which the contralateral renal function was normal, the contralateral kidney likely compensated for the postoperative loss of renal function [ 21 , 22 ]. Second, the preoperative and postoperative remnant kidney volume and removed kidney volume have been shown to affect the recovery of renal function [ 23 - 25 ].…”

Section: Discussionmentioning

confidence: 99%

A Study of Relationship of Atheroembolic Risk Factors with Postoperative Recovery in Renal Function after Partial Nephrectomy in Patients Staged T1-2 Renal Cell Carcinoma during Median 4-Year Follow-up

Kim

Kang

et al. 2016

Cancer Res Treat

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PurposeThe objective of this study is to evaluate the relationship of atheroembolic risk factors with postoperative recovery of renal function after on-clamp partial nephrectomy (PN) with warm ischemia in patients with staged T1-2 renal cell carcinoma (RCC).Materials and MethodsA total of 234 patients from 2004 to 2012 were included, and their clinicopathologic and operative parameters, including atheroembolic risk factors were reviewed retrospectively. Renal function, as determined by estimated glomerular filtration rate (eGFR) and measurement of serum creatinine level (Cr) at each scheduled follow-up for a median four years, was compared between the high-risk (HR) group (n=49, ≥ five risk factors) and the low-risk (LR) group (n=185, < five risk factors).ResultsExcept for baseline renal function and number of risk factors for atheroembolism, differences in characteristics between groups were comparatively insignificant. At 3 months after the operation, Cr and eGFR differed significantly between the two groups (p < 0.05), but no differences were observed afterward. Significant deterioration from baseline in Cr and eGFR was observed in both groups at 1 month after the operation, with a greater change in the HR group (p < 0.05). From measurement to measurement, significantly faster deterioration in Cr and eGFR was observed in the HR group than in the LR group until 6 months after the operation (Cr: LR, 0.02 mg/dL and HR, 0.13 mg/dL; eGFR: LR, 1.50 mL/min/1.73 m2 and HR, 6.38 mL/min/1.73 m2; p < 0.05).ConclusionThe presence of atheroembolic risk factors may negatively influence postoperative recovery of renal function after PN in patients with localized RCC.

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