Residual Gastric Dilatation Interferes with Metabolic Improvements Following Sleeve Gastrectomy by Upregulating the Expression of Sodium-Glucose Cotransporter-1

Xia, Jun; He, Qian; He, Ming; Xu, Guojun; Ren, Yixing

doi:10.1007/s11695-019-03997-z

Cited by 5 publications

(8 citation statements)

References 27 publications

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“…After RYGB and/or DJB in healthy and diabetic rodents, mucosal surface area and villi length in the bypassed foregut were decreased which was combined with a reduction of Sglt1-mediated AMG uptake per intestinal length [183,209,290,426]. In the proximal alimentary limbs after RYGB and GJB receiving bile-less undigested food, mucosal hypertrophy with increased mucosal surface area, villi length, and increased number of L cells was observed [44,59,145,274,334,368,429].…”

Section: Proposed Functional Mechanismsmentioning

confidence: 98%

“…One month after VSG in mice, the body weight of the animals was reduced and the increase of blood glucose after OGTT was blunted [426]. In the jejunum, Sglt1 mRNA and abundance of Sglt1 protein in the BBM were decreased [426].…”

Section: Proposed Functional Mechanismsmentioning

confidence: 99%

“…Effects on intestinal structure and glucose transporters Alimentary-mediated stimulators trigger enterohormonemediated and/or nervous signals that promote proliferation and differentiation of small intestinal mucosa [352]. Hence, small intestinal segments that are excluded from contact with nutrients such as the bile limbs in RYGB and DJB or from contact with enzymatically digested nutrients such as the proximal alimentary limbs in RYGB and DLB undergo morphological changes [209,426]. These changes may be atrophic or hyperplastic including a decrease or increase of the mucosal surface, respectively.…”

Section: Proposed Functional Mechanismsmentioning

confidence: 99%

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Glucose transporters in the small intestine in health and disease

Koepsell

2020

Pflugers Arch - Eur J Physiol

144

124

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Absorption of monosaccharides is mainly mediated by Na +-D-glucose cotransporter SGLT1 and the facititative transporters GLUT2 and GLUT5. SGLT1 and GLUT2 are relevant for absorption of D-glucose and D-galactose while GLUT5 is relevant for D-fructose absorption. SGLT1 and GLUT5 are constantly localized in the brush border membrane (BBM) of enterocytes, whereas GLUT2 is localized in the basolateral membrane (BLM) or the BBM plus BLM at low and high luminal D-glucose concentrations, respectively. At high luminal D-glucose, the abundance SGLT1 in the BBM is increased. Hence, D-glucose absorption at low luminal glucose is mediated via SGLT1 in the BBM and GLUT2 in the BLM whereas high-capacity D-glucose absorption at high luminal glucose is mediated by SGLT1 plus GLUT2 in the BBM and GLUT2 in the BLM. The review describes functions and regulations of SGLT1, GLUT2, and GLUT5 in the small intestine including diurnal variations and carbohydrate-dependent regulations. Also, the roles of SGLT1 and GLUT2 for secretion of enterohormones are discussed. Furthermore, diseases are described that are caused by malfunctions of small intestinal monosaccharide transporters, such as glucose-galactose malabsorption, Fanconi syndrome, and fructose intolerance. Moreover, it is reported how diabetes, small intestinal inflammation, parental nutrition, bariatric surgery, and metformin treatment affect expression of monosaccharide transporters in the small intestine. Finally, food components that decrease D-glucose absorption and drugs in development that inhibit or downregulate SGLT1 in the small intestine are compiled. Models for regulations and combined functions of glucose transporters, and for interplay between D-fructose transport and metabolism, are discussed.

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Section: Proposed Functional Mechanismsmentioning

confidence: 98%

Section: Proposed Functional Mechanismsmentioning

confidence: 99%

Section: Proposed Functional Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Glucose transporters in the small intestine in health and disease

Koepsell

2020

Pflugers Arch - Eur J Physiol

144

124

View full text Add to dashboard Cite

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“…In addition to gut microbiota, bile acids, gastrointestinal hormones and cytokines, metabolic surgery activates other mechanisms, such as autophagy, DNA methylation ( Liu et al, 2019a ), changes in microRNA expression ( Qian et al., 2014 ; Zhu et al, 2017 ), changes in genetics ( Li et al, 2019 ), endoplasmic reticulum (ER) stress ( Li et al, 2016 ), changes in Na + -coupled glucose transporters (SGLT) and glucose transporter facilitators (GLUT) in the gut ( Li et al, 2012 ; Yan et al, 2013b ; Xia et al, 2019 ), and activating insulin signaling in the brain ( Li et al, 2020b ).…”

Section: Mechanism For Weight Loss and T2dm Remissionmentioning

confidence: 99%

“…RYGB may improve IR and treat T2DM through downregulation of tumor necrosis factor α mRNA transcription, upregulation of peroxisome proliferator-activated receptor γ2, phosphatidylinositol-3-kinase subunit p85α, GLUT4 mRNA transcripts, and inducing translocation of GLUT4 in adipose tissue ( Li et al, 2012 ). Residual gastric dilatation interferes with metabolic improvements following SG by upregulating the expression of SGLT1 ( Xia et al, 2019 ).…”

Section: Mechanism For Weight Loss and T2dm Remissionmentioning

confidence: 99%

Metabolic surgery in China: present and future

Bao

2021

Journal of Molecular Cell Biology

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Obesity and its related complications comprise a serious public health problem worldwide, and obesity is increasing in China. Metabolic surgery is a new type of treatment with unique advantages in weight loss and obesity-related metabolic complications. The pathogenesis of obesity is complex and not yet fully understood. Here, we review the current efficacy and safety of metabolic surgery, as well as recent progress in mechanistic studies and surgical procedures in China. The exciting and rapid advances in this field provide new opportunities for patients with obesity and strike a balance between long-term effectiveness and safety.

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The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review

Walmsley,

Chong,

Hii

et al. 2024

Rev Endocr Metab Disord

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Gastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of bariatric surgery. Databases searched included Medline, Embase, Emcare, APA PsychInfo, Cochrane Library, and CINAHL. Two human and 21 animal studies were included. Bariatric surgery alters the quantity of many sweet, umami, and fatty acid taste receptors in the gastrointestinal tract. Changes to the expression of sweet and amino acid receptors occur most often in intestinal segments surgically repositioned more proximally, such as the alimentary limb after gastric bypass. Conversely, changes to fatty acid receptors were observed more frequently in the colon than in the small intestine. Significant heterogeneity in the methodology of included studies limited conclusions regarding the direction of change in taste receptor expression induced by bariatric surgeries. Few studies have investigated associations between taste receptor expression and clinical outcomes of bariatric surgery. As such, future studies should look to investigate the relationship between bariatric surgery-induced changes to gut taste receptor expression and function and the impact of surgery on taste preferences, food palatability, and eating behaviour.Registration code in PROSPERO: CRD42022313992

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Residual Gastric Dilatation Interferes with Metabolic Improvements Following Sleeve Gastrectomy by Upregulating the Expression of Sodium-Glucose Cotransporter-1

Cited by 5 publications

References 27 publications

Glucose transporters in the small intestine in health and disease

Glucose transporters in the small intestine in health and disease

Metabolic surgery in China: present and future

The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review

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