Residual disability 10years after falling ill in Guillain–Barré syndrome: A prospective follow-up study

Forsberg, Anette; Holmqvist, Lotta Widén

doi:10.1016/j.jns.2012.02.026

Cited by 41 publications

(51 citation statements)

References 32 publications

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“…We used MRC sum-score to assess severity of weakness in our study and found no association between fatigue and weakness as in study by Garssen et al [11] We found a positive correlation between fatigue at the time of discharge and HDS scores ≥3. Other studies[6910] have also found correlation between fatigue and disability.…”

Section: Discussionmentioning

confidence: 87%

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Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting

Ranjani

Khanna

Gupta

et al. 2014

Ann Indian Acad Neurol

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Background:Fatigue contributes significantly to the morbidity and affects the quality of life adversely in Guillain-Barre Syndrome (GBS).Objective:To determine the prevalence of fatigue in GBS in neurological rehabilitation setting and to study its clinical correlates.Materials and Methods:We performed secondary analysis of data of patients with GBS admitted in neurological rehabilitation ward of a tertiary care centre, recorded at both admission and discharge. Assessment of fatigue was done by Fatigue Severity Scale (FSS), disability-status by Hughe's Disability Scale (HDS), functional-status by Barthel Index, anxiety/depression by Hospital Anxiety Depression Scale, sleep disturbances by Pittsburgh Sleep Quality Index and muscle weakness by Medical Research Council sum scores.Results:A total of 90 patients (62 men) with mean age 34 years (95% CI 32.2, 37.7) were included. Median duration of, stay at neurological rehabilitation ward was 30 days, while that of symptoms was 18.5 days. Presence of fatigue at admission (FSS ≥ 4 in 39% patients) was associated with ventilator requirement (P = 0.021) and neuropathic pain (P = 0.03). Presence of fatigue at discharge (FSS ≥ 4 in 12% patients) was associated with disability- HDS (≥3) (P = 0.008), presence of anxiety (P = 0.042) and duration of stay at rehabilitation ward (P = 0.02). Fatigue did not correlate with age, gender, antecedent illness, muscle weakness, depression and sleep disturbances.Conclusion:Fatigue is prevalent in GBS during early recovery phase of illness. Despite motor recovery fatigue may persist. Knowledge about fatigue as burden of disease in these patients will improve patient care.

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Section: Discussionmentioning

confidence: 87%

“…Most of the studies[691011] have focused on the prevalence of fatigue, following maximal recovery. After extensive literature search, we could not find any study that has seen prevalence of fatigue in GBS in subacute setting.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting

Ranjani

Khanna

Gupta

et al. 2014

Ann Indian Acad Neurol

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“…Peripheral neuropathies are rarely curable, and rehabilitation clinicians manage the symptoms using adaptive equipment, orthoses, 15 -19 modalities, 20 , 21 aerobic exercises to address deconditioning and residual dysfunction, 22 resistive exercises for strengthening, 23 balance regimens and gait training, 24 or a combination of these to prevent deformities and maximize function and participation. In additions, therapists work with patients who are receiving medications for their neuropathic symptoms.…”

Section: Interventionsmentioning

confidence: 99%

Peripheral Neuropathies and Exercise

Smith

Mulligan

2014

Topics in Geriatric Rehabilitation

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“…7 Patients' quality of life (QoL) in GBS may be negatively affected due to all these factors. [9][10][11] Majority of studies on QoL in GBS patients used generic questionnaires, such as SF36. Only several studies presented longitudinal QoL data in GBS.…”

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confidence: 99%

Six‐month prospective study of quality of life in Guillain‐Barre syndrome

et al. 2019

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Objective Guillain‐Barre syndrome (GBS) is an acute disease of the peripheral nerves and their roots. Quality of life (QoL) in the first year after acute episode of GBS is still underresearched area. The aim of our study was to investigate QoL in GBS patients during a 6‐month follow‐up period. Methods Multicentric, prospective study included 74 adult patients with GBS (54% males). GBS disability scale (GDS) was used to assess functional disability (severe disability GDS > 2), and Individualized Neuromuscular Quality of Life Questionnaire (INQoL) to asses QoL. Patients were tested on day 14, day 28, month 3, and month 6 from symptom onset. Results Disability as measured by GDS improved during time (P < .01). INQoL scores also improved during time (P < .01) but were not able to differentiate between day 14 and day 28, and some scores also did not make difference between month 3 and 6 (pain, social relations, emotions and total INQoL score; P > .05). Pooled GDS scores correlated with pooled INQoL scores, especially with independence, activities, and weakness subscores (P < .01). Multiple linear regression analysis showed that GDS at day 14 (β = .52, P < .01) and fatigue score at day 14 (β = .41, P < .01) were independent predictors of the worse GDS at month 6 (adjusted R2 = .34, P < .01 for overall model). Conclusions During a 6‐month follow‐up period of GBS patients, we observed a gradual recovery of patients' disability and QoL. Our study confirms the importance of patient‐reported outcomes and their ability to capture some important issues that are omitted by classic ability measures such as GDS.

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Residual disability 10years after falling ill in Guillain–Barré syndrome: A prospective follow-up study

Cited by 41 publications

References 32 publications

Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting

Prevalence of fatigue in Guillain-Barre syndrome in neurological rehabilitation setting

Peripheral Neuropathies and Exercise

Six‐month prospective study of quality of life in Guillain‐Barre syndrome

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