Residual Copper(II) Detection in Chemical Processes: High-Throughput Analysis and Real-Time Monitoring with a Colorimetric Copper Probe

Jung, Ju‐Yang; Jo, Junyong

doi:10.1021/acs.oprd.9b00045

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…6C). [44][45][46][47][48][49][50][51][52][53][54] These probes demonstrated better water solubility, better selectivity, better biocompatibility, higher sensitivity through structural modication, and were applied in cell imaging or paper-based detection devices.…”

Section: Probes For Anionsmentioning

confidence: 99%

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

Chen

Huang

et al. 2022

RSC Adv.

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Section: Probes For Anionsmentioning

confidence: 99%

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

Chen

Huang

et al. 2022

RSC Adv.

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“…During the last century, instruments for laboratory use have become more and more technologically advanced. − Laboratories have been migrating from the traditional glassware-based setups to utilizing automated systems that reduce the need for manual intervention and liberate researcher time. , In the past few years, efforts of bridging laboratory electronic hardware and computers have been made to reach control integration and automation. , Beyond simply using preprogrammed software to control instrumentation, embracing the advancements in laboratory instruments enable scientists to conduct research without performing repetitive procedures or adjusting reaction configurations by physically being near a setup. − …”

Section: Introductionmentioning

confidence: 99%

Augmented Titration Setup for Future Teaching Laboratories

et al. 2021

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Teaching laboratories are designed to educate students on basic theories and techniques through guided laboratory experiments. As advances in automation revolutionize research chemistry laboratories, teaching tools can advance to reflect these changes. In this study, we integrated several programmable instruments, including automated pumps for liquid transfer, into an augmented titration setup that can be operated remotely. Our setup empowers students to learn the conceptual, technical, and practical aspects of titration by leveraging laboratory automation tools. Our system uses Siri as a speech recognition tool and the Python programming language to develop action routines for titration uses. The application of Siri provides a smooth user-toinstrument experience, and the use of Python allows coders to effectively develop and maintain the workflow. Three chemistry professors were invited to participate in usability tests of the system using a mobile device. Their positive feedback highlights the promise of our system as a valuable addition to undergraduate chemistry teaching laboratories. This titration setup addresses accessibility challenges and distance learning requirements for chemical education. Further, our tool introduces students to the type of automated experimentation that is emerging as the modern standard in chemistry research laboratories.

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“…Biological applications of probe molecules can readily be exemplified as an area where other techniques are not practical but molecular probes would overcome such challenges. In addition, the capability of high-throughput analysis is another appealing feature of a detector molecule over the existing techniques, and its application is repeatedly reported in the industrial setting including pharmaceutical processes. − …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Comparative Kinetic Study of Reaction-Based Copper(II) Probes to Visualize Aromatic Substituent Effects on Reactivity

2020

Self Cite

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Recently, researchers have paid extensive attention to colorimetric/fluorimetric probe development and its applications in biological and industrial samples. The actual development of such probe molecules, however, often requires an iterative process to achieve certain goals such as selectivity and sensitivity toward a target analyte. In spite of growing interest in the development of practical molecular probes, there has not been much effort to implement the synthesis of detector molecules and the examination of their structure–reactivity relationship in undergraduate laboratories. A straightforward synthesis of copper probe molecules, which are systematically varied with aromatic substituents, is described to compare the reactivity toward copper(II) ion. The comparative kinetic study can readily visualize how the number and position of aromatic substituents affect the reactivity. This experiment is appropriate to demonstrate how mechanistic understanding will provide significant insight into rational design of practical colorimetric/fluorimetric probe molecules.

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Residual Copper(II) Detection in Chemical Processes: High-Throughput Analysis and Real-Time Monitoring with a Colorimetric Copper Probe

Cited by 5 publications

References 20 publications

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

Augmented Titration Setup for Future Teaching Laboratories

Synthesis and Comparative Kinetic Study of Reaction-Based Copper(II) Probes to Visualize Aromatic Substituent Effects on Reactivity

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