Residual biomasses and protein hydrolysates of three green microalgae species exhibit antioxidant and anti-aging activity

Norzagaray-Valenzuela, Claudia D.; Valdéz-Ortiz, Ángel; Shelton, Luke M.; Jiménez-Edeza, Maribel; Rivera-López, Javier; Valdez-Flores, Marco A.; Germán-Báez, Lourdes J.

doi:10.1007/s10811-016-0938-9

Cited by 44 publications

(31 citation statements)

References 77 publications

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“…For example, residual biomass and protein hydrolysates of three species of green microalgae (Dunaliella tertiolecta, Tetraselmis suecica, and Nannochloropsis sp.) have been reported to exhibit antioxidant and antiaging activity (see Table 1) [31,233]. Antiaging, skin whitening, and pigmentation reduction products were created from bioactive extracts from algae [234].…”

Section: Skin Agingmentioning

confidence: 99%

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Seaweeds as Source of Bioactive Substances and Skin Care Therapy—Cosmeceuticals, Algotheraphy, and Thalassotherapy

2018

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Riverine, estuarine, and coastal populations have always used algae in the development of home remedies that were then used to treat diverse health problems. The empirical knowledge of various generations originated these applications, and their mechanism of action is, in most cases, unknown, that is, few more scientific studies would have been described beyond simple collection and ethnographic recording. Nevertheless, recent investigations, carried out with the purpose of analyzing the components and causes that alter the functioning and the balance of our organism, are already giving their first results. Water, and especially sea water is considered as essential to life on our planet. It sings all the substances necessary and conducive to the development of the living being (minerals, catalysts, vitamins, amino acids, etc.). Oceans cover over 70% of Earth, being home to up to 90% of the organisms in the planet. Many rich resources and unique environments are provided by the ocean. Additionally, bioactive compounds that multiple marine organisms have a great potential to produce can be used as nutraceuticals, pharmaceuticals, and cosmeceuticals. Both primary and secondary metabolites are produced by algae. The first ones are directly implicated in development, normal growth, or reproduction conditions to perform physiological functions. Stress conditions, like temperature changes, salinity, environmental pollutants, or UV radiation exposure cause the performance of secondary metabolites. In algae, proteins, polysaccharides, fatty acids, and amino acids are primary metabolites and phenolic compounds, pigments, vitamins, sterols, and other bioactive agents, all produced in algae tissues, are secondary metabolites. These algal active constituents have direct relevance in cosmetics.

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Section: Skin Agingmentioning

confidence: 99%

“…Tyrosinase inhibitors, antiaging, anti-inflammatory, antioxidant, adical scavengers, antiphotoaging agents, and colorants [27,29,30] D. tertiolecta * Phenolic compund Anti-aging [31] Tetraselmis suecica * Phenolic compund Anti-aging [31] Haematococcus lacustris (as H. pluvialis) * Carotenoids (astaxanthin, β-carotene, fucoxanthin, lutein)…”

Section: Introductionmentioning

confidence: 99%

Seaweeds as Source of Bioactive Substances and Skin Care Therapy—Cosmeceuticals, Algotheraphy, and Thalassotherapy

2018

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“…7 Therefore, the prime mover for anti-aging strategy to achieve healthy, smooth, blemish free and resilient skin is by means of controlling the degradation of the skin structural constituents with regulation of proteinase activity. 12,28 With its intrinsically high antioxidant activity, C.emersonii KJ725233 was taken up for assessing its potential as a proteinase inhibitor in the present study. The anti -elastase activity of its methanolic extract was evaluated using SAAANA as a substrate and the percent enzyme inhibition was correlated to the amount of p -nitroaniline formed.…”

Section: Anti -Aging Activitymentioning

confidence: 99%

“…Although the IC 50 value was found to be equivalent to that of C.emersonii 11N i.e 0.42±0.05 mg/mL, it was lower than that of 0.503±0.06 mg/mL for Tetraselmis suecica. 28,29 Although the methanolic extract of C.emersonii KJ725233 exhibited a modest anti-hyaluronidase activity of 39.32±0.92% at 1000 µg/mL (Table1); its IC 50 of 1.58±0.06 mg/mL (Figure 1) was fivefold lower than that of Dunaliella tertiolecta (5.542±0.12 mg/mL), Tetraselmis suecica (5.907±0.26 mg/mL) and four fold lower than that of Nannochloropsis species (4.202±0.33 mg/mL) as previously reported. 28 The methanolic extract of C.emersonii KJ725233 exhibited a significant anti -elastase and a modest anti -hyaluronidase activity however, its anti -collagenase potential was found to be less significant with a percent inhibition of 20.33±2.90% at 1000 µg/mL (Table 1) with an IC 50 of 2.50±0.03 mg/mL (Figure 1).…”

Section: Anti -Aging Activitymentioning

confidence: 99%

“…1 ROS induces the over expression of the matrix metalloproteinases and serine proteinases in the fibroblasts therefore causing the remodelling of skin extracellular matrix, resulting in skin damage. 28,29,30 To combat this oxidative stress, there is need to scavenge these free radicals. The methanolic extract of C.emersonii KJ725233 was thus evaluated for its radical scavenging potential by the DPPH method (Figure 2).…”

Section: Radical Scavenging Potential and Total Flavonoid Contentmentioning

confidence: 99%

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Correlating the Anti – Aging Activity with the Bioactive Profile of Chlorella emersonii KJ725233; Its Toxicological Studies for a Potential use in Cosmeceuticals

Sawant¹,

Mane²

2017

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Background: Microalgae due to an array of its antioxidant, antimicrobial and anti-inflammatory bioactives have been changing the cosmeceutical market. One such bioactive power pack is Chlorella emersonii KJ725233, a novel, non-fastidious freshwater microalga with an inherently higher antioxidant potential. Objective: The present study evaluates its potential use as a cosmeceutical ingredient with arrays of biochemical assays, toxicity studies and GC-HRMS profiling. Materials and Methods: In vitro proteinase inhibition activity of the methanolic extract of C.emersonii KJ725233 was evaluated using SAAANA, sodium hyaluronate and bovine collagen as substrates respectively. The radical scavenging potential was determined by DPPH assay and was correlated to the total flavonoid content evaluated by aluminium trichloride method. The bioactive composition was evaluated by GC -HRMS analysis. Eye irritation potential and sulforhodamine B assay were carried out using 3T3 fibroblasts cells to ascertain its non-toxic nature. Results: The methanolic extract of C.emersonii KJ725233 exhibited a potent elastase inhibition of 92.04±2.27% at a concentration of 1000 µg/mL. This was qualitatively established by the presence of phytol, its isomer and other anti-inflammatory molecules as revealed by GC HRMS profile. Its radical scavenging potential with an IC 50 of 5.398±0.138 mg/mL exhibited a correlation coefficient of 0.9977 with its total flavonoid content. Toxicological studies on 3T3 fibroblast cell lines revealed its non -toxic as well as non -eye irritant nature. Conclusion: Its potential anti-aging and antioxidant activity coupled with its non-toxicity thus puts this microalga in the spot light for use in cosmeceutical industry.

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Marine Macroalgae as a Treasure House of Bioactive Compounds and Nutraceuticals

Chakraborty

2023

Bioprospecting of Tropical Medicinal Plants

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Residual biomasses and protein hydrolysates of three green microalgae species exhibit antioxidant and anti-aging activity

Cited by 44 publications

References 77 publications

Seaweeds as Source of Bioactive Substances and Skin Care Therapy—Cosmeceuticals, Algotheraphy, and Thalassotherapy

Seaweeds as Source of Bioactive Substances and Skin Care Therapy—Cosmeceuticals, Algotheraphy, and Thalassotherapy

Correlating the Anti – Aging Activity with the Bioactive Profile of Chlorella emersonii KJ725233; Its Toxicological Studies for a Potential use in Cosmeceuticals

Marine Macroalgae as a Treasure House of Bioactive Compounds and Nutraceuticals

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