Residual aortic regurgitation is a major determinant of late mortality after transcatheter aortic valve implantation

Trans‐subclavian versus transapical access for transcatheter aortic valve implantation: A multicenter study

“…In our study, residual aortic regurgitation grade moderate‐to‐severe (grade ≥3+) after TAVI was an independent predictor of mortality during follow‐up (HR 3.4).The overall incidence of aortic regurgitation was 48.2% (31.1% mild, 14.0% moderate, and 3.2% moderate‐to‐severe or severe), which is similar to that observed in other registries and randomized trials .While the prognostic impact of lower degrees of residual aortic regurgitation remains debated it is clear that every measure has to be taken to prevent or reduce residual aortic regurgitation in order to improve the clinical outcome of TAVI. Additional important predictors of mortality after TAVI in our study were sepsis (HR 6.1) and life‐threatening bleeding (HR 2.8), a finding consistent with other registries comprising transfemoral procedures which highlights the need for careful procedural and postprocedural management in these fragile patients.…”

Does mild paravalvular regurgitation post transcatheter aortic valve implantation affect survival? A meta‐analysis

“…Our initial literature search resulted in total of 3,447 articles. A total of 25 articles [3,[6][7][8][9][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] including total of 21,018 patients were finally included for quantitative synthesis (meta-analysis). Detailed study selection flow is summarized in Supporting Information 1.…”

Practical determination of aortic valve calcium volume score on contrast-enhanced computed tomography prior to transcatheter aortic valve replacement and impact on paravalvular regurgitation: Elucidating optimal threshold cutoffs

“…Paravalvular aortic regurgitation (PVR) is a complication of TAVR which is associated with mortality, as reported in previous studies. [5][6][7][8] PVR results from a lack of sealing between the bioprosthesis and the aortic annulus caused by multiple factors, which include undersizing, THV depth 9, 10 , and calcification. Post-procedural PVR is more frequent in self-expanding than in other TAVR platforms.…”