Residual and recurrent disease rates following LEEP treatment in high-grade cervical intraepithelial lesions

Baloğlu, Ali; Uysal, Dilek; Bezircioglu, Incim; Biçer, Merve; Inci, Ayşegul

doi:10.1007/s00404-009-1298-3

Cited by 43 publications

(49 citation statements)

References 15 publications

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“…However, many recurrences and persistence of high-risk HPV DNA were still found (Aerssens et al, 2008). Therefore, a follow-up including HPV detection and Pap-smears of all patients after LEEP is strongly recommended (Baloglu et al, 2010). In contrast, in the MVA E2-treated group, only 5 (3.5%) out of 141 female patients with high-grade lesions showed the appearance of lesions in a period of 2 years after treatment.…”

Section: Discussionmentioning

confidence: 94%

Regression of Human Papillomavirus Intraepithelial Lesions Is Induced by MVA E2 Therapeutic Vaccine

et al. 2014

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Human papilloma viruses can induce warts, condylomas, and other intraepithelial cervical lesions that can progress to cancer. Cervical cancer is a serious problem in developing countries because early detection is difficult, and thus proper early treatment is many times missing. In this phase III clinical trial, we evaluated the potential use of MVA E2 recombinant vaccinia virus to treat intraepithelial lesions associated with papillomavirus infection. A total of 1176 female and 180 male patients with intraepithelial lesions were studied. They were injected with 10 7 MVA E2 virus particles directly into their uterus, urethra, vulva, or anus. Patients were monitored by colposcopy and cytology. Immune response was determined by measuring the antibody titer against MVA E2 virus and by analyzing the cytotoxic activity against cancer cells bearing papillomavirus DNA. Papillomavirus was determined by the Hybrid Capture method or by polymerase chain reaction analysis. By histology, 1051 (89.3%) female patients showed complete elimination of lesions after treatment with MVA E2. In 28 (2.4%) female patients, the lesion was reduced to CIN 1. Another 97 (8.3%) female patients presented isolated koilocytes after treatment. In men, all lesions were completely eliminated. All MVA E2-treated patients developed antibodies against the MVA E2 vaccine and generated a specific cytotoxic response against papilloma-transformed cells. Papillomavirus DNA was not detected after treatment in 83% of total patients treated. MVA E2 did not generate any apparent side effects. These data suggest that therapeutic vaccination with MVA E2 vaccine is an excellent candidate to stimulate the immune system and generate regression in intraepithelial lesions when applied locally.

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Section: Discussionmentioning

confidence: 94%

Regression of Human Papillomavirus Intraepithelial Lesions Is Induced by MVA E2 Therapeutic Vaccine

et al. 2014

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“…For young women, diagnosis and establishment of the correct degree of the precursor lesion is essential for adopting the appropriate therapeutic intervention to prevent the cervical carcinoma from developing further. LEEP is a conservative treatment, and is indicated in women of reproductive age to avoid complications in the case of a future pregnancy [1,15]. Some investigators have reported that LEEP has no important adverse effects on fertility [15,16].…”

Section: Discussionmentioning

confidence: 98%

“…If these lesions are diagnosed early and treated appropriately, SCC development is interrupted [1,2]. Loop electrosurgical excision procedure (LEEP) is an excellent treatment option for precancerous cervical lesions [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

The “see and treat” strategy for identifying cytologic high-grade precancerous cervical lesions among low-income Brazilian women

Nogara

Manfroni²,

Silva

et al. 2012

International Journal of Gynecology & Obstetrics

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“…most of the studies demonstrate that the margins affections increase the risk of illness residual [24,25] significantly. In the study of Houfflin-Debargue et al [26] the patients with positive margins were 36%, in the study of Serati et al [27], 32% of the patients presented margins affections and it was found that this was the factor more important predictor of recurrent illness, the same as in the works of Prato [28] and Baloglu et al [29].…”

Section: Design Methodologicalmentioning

confidence: 68%

Factors predictors of residual illness in patient conizadas for lesions micro invaders and of high degree

Gómez¹,

Rodríguez²

2017

Clin Obstet Gynecol Reprod Med

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In Cuba, the cervical cancer constitutes an important problem of health for its high indexes of morbi-mortality and emotional impact in the population. In the handling of the women with their lesions precursors, the objective consists on preventing the possible progression to cancer invader without sobretratar the lesions with high regression probabilities. Along the time different treatments and protocols have been proven in order to obtaining the best results in the control of this pathology with conservative techniques, in the face of the growing incidence in patient without satisfied parity and minimizing the possibility of residual illness. It was carried out a prospective descriptive study to determine the relationship between the diagnosis of residual illness and clinical-epidemic factors in 428 patients with lesions cervical epithelial of high degree that were conization in the Hospital General Educational Heroes of the Baire during the period 2014-2016. 53% of the studied patients was bigger than 35 years of age, 74% had one or two children, 20% smoked, 38% had an initial cytology of high degree, 46% they had a lesion with an area of 100-199mm2, 90% they were conization for handle diathermic and 29% they were conization for not correlation diagnostics. The surgical margins affected by lesion, the carcinoma histology in situ or micro invader, the area of more lesion 199mm2 and the glandular lesions of the cervical channel constituted factors predictors of residual illness. The presence of these factors predictors meant 79,6% of probability of appearance of residual lesion.

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Residual and recurrent disease rates following LEEP treatment in high-grade cervical intraepithelial lesions

Cited by 43 publications

References 15 publications

Regression of Human Papillomavirus Intraepithelial Lesions Is Induced by MVA E2 Therapeutic Vaccine

Regression of Human Papillomavirus Intraepithelial Lesions Is Induced by MVA E2 Therapeutic Vaccine

The “see and treat” strategy for identifying cytologic high-grade precancerous cervical lesions among low-income Brazilian women

Factors predictors of residual illness in patient conizadas for lesions micro invaders and of high degree

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