Residential ultraviolet radiation and breast cancer risk in a large prospective cohort

Gregoire, Allyson M.; VoPham, Trang; Laden, Francine; Yarosh, Rina; O’Brien, Katie M.; Sandler, Dale P.; White, Alexandra J.

doi:10.1016/j.envint.2021.107028

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…A large prospective cohort study in the USA investigated incidence of breast cancer in association with UV exposure (expressed as mW/m 2 ), categorized in quintiles. 53 In this study, there was no association with the overall incidence of breast cancer, but higher UV levels were associated with a lower risk of estrogen receptor-negative (ER-) breast cancer (hazard ratio 0.73, 95% CI: 0.55–0.99).…”

Section: Health Benefits Of Uv Exposure At Workmentioning

confidence: 57%

Workplace exposure to UV radiation and strategies to minimize cancer risk

Cherrie

2022

British Medical Bulletin

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Background Workplace exposure to solar ultraviolet (UV) causes malignant melanoma and non-melanoma skin cancer. The evidence for beneficial effects of solar UV exposure in reducing the risks for other cancers is increasing. The intensity of UV radiation at the Earth’s surface is dependent on latitude, but even in northern European countries exposure can be high enough for outdoor work to cause skin cancer. Growing points Awareness of the health risks and benefits of occupational solar UV exposure is poor. Actions to reduce the risk of skin cancer have been identified and employers should recognize their responsibility to actively manage these risks. There is evidence for reduced risks for breast, ovarian and colorectal cancer and possibly other cancers linked to solar UV exposure. Sources of data This narrative review draws on published scientific articles and material designed to assist identifying strategies to protect workers from solar UV exposure. Areas of agreement Solar UV exposure can be harmful. Wavelengths in the UVB range are more effective in causing erythema and DNA damage. Solar UV is the main source of vitamin D for most people. Primary and secondary prevention for skin cancer can potentially eliminate these risks but the evidence for effectiveness is limited. Areas of controversy Potential health benefits of UV exposure, particularly for reduced cancer risk. Determining and communicating optimal exposure to maximize health benefits. The risk of non-melanoma skin cancers may be more than doubled for some workers in temperate latitudes. Areas timely for developing research Exposure-response epidemiological studies; studies of the health benefits of occupational UV exposure; studies of the effectiveness of intervention strategies to prevent skin cancer. Use of low-cost UV sensors in workplaces.

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Section: Health Benefits Of Uv Exposure At Workmentioning

confidence: 57%

Workplace exposure to UV radiation and strategies to minimize cancer risk

Cherrie

2022

British Medical Bulletin

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“…In a very recent study conducted by Gregoire et al, exposure to UV rays was broken down into quintiles and the authors concluded that there was no correlation between UV exposure and the overall risk of breast cancer. Higher UV exposure, however, was inversely linked to a lower incidence of one breast cancer type (without estrogen receptors (ER) 62 .…”

Section: Resultsmentioning

confidence: 99%

Impacts of socioeconomic and environmental factors on neoplasms incidence rates using machine learning and GIS: a cross-sectional study in Iran

Rafiee,

Jahangiri-rad,

Mohseni-Bandpei

et al. 2024

Sci Rep

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Neoplasm is an umbrella term used to describe either benign or malignant conditions. The correlations between socioeconomic and environmental factors and the occurrence of new-onset of neoplasms have already been demonstrated in a body of research. Nevertheless, few studies have specifically dealt with the nature of relationship, significance of risk factors, and geographic variation of them, particularly in low- and middle-income communities. This study, thus, set out to (1) analyze spatiotemporal variations of the age-adjusted incidence rate (AAIR) of neoplasms in Iran throughout five time periods, (2) investigate relationships between a collection of environmental and socioeconomic indicators and the AAIR of neoplasms all over the country, and (3) evaluate geographical alterations in their relative importance. Our cross-sectional study design was based on county-level data from 2010 to 2020. AAIR of neoplasms data was acquired from the Institute for Health Metrics and Evaluation (IHME). HotSpot analyses and Anselin Local Moran's I indices were deployed to precisely identify AAIR of neoplasms high- and low-risk clusters. Multi-scale geographically weight regression (MGWR) analysis was worked out to evaluate the association between each explanatory variable and the AAIR of neoplasms. Utilizing random forests (RF), we also examined the relationships between environmental (e.g., UV index and PM2.5 concentration) and socioeconomic (e.g., Gini coefficient and literacy rate) factors and AAIR of neoplasms. AAIR of neoplasms displayed a significant increasing trend over the study period. According to the MGWR, the only factor that significantly varied spatially and was associated with the AAIR of neoplasms in Iran was the UV index. A good accuracy RF model was confirmed for both training and testing data with correlation coefficients R2 greater than 0.91 and 0.92, respectively. UV index and Gini coefficient ranked the highest variables in the prediction of AAIR of neoplasms, based on the relative influence of each variable. More research using machine learning approaches taking the advantages of considering all possible determinants is required to assess health strategies outcomes and properly formulate policy planning.

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“…However, Rylander et al (2019) concluded that intensive use of skin care products did not increase the BCR [ 86 ]. On the other hand, 70–100% of patients receiving radiation therapy following BC experienced radiation-induced skin toxicity [ 88 ] comparable to UV exposure, which was associated with decreased postmenopausal BCR, due to higher circulating concentration of a precursor to the active form of vitamin D [ 89 ]. In addition, the gut absorbs dietary nutrients and provides a barrier to many xenobiotics and microbiome-derived metabolites, so the intestinal epithelium becomes one of the most rapidly proliferating tissues in the body, assuring a rapid and effective elimination of some xenobiotics that bioaccumulate in enterocytes [ 90 ].…”

Section: Absorption Distribution Metabolism/biotransformation Bioaccu...mentioning

confidence: 99%

Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

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We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an important role in BC initiation and progression. Many considerations necessitate a more valuable explanation regarding the molecular mechanisms of action of xenobiotics which act as genotoxic and epigenetic carcinogens. Thus, exposomics and the exposome concept are based on the diversity and range of exposures to physical factors, synthetic chemicals, dietary components, and psychosocial stressors, as well as their associated biologic processes and molecular pathways. Existing evidence for BC risk (BCR) suggests that food-borne chemical carcinogens, air pollution, ionizing radiation, and socioeconomic status are closely related to breast carcinogenesis. The aim of this review was to depict the dynamics and kinetics of several xenobiotics involved in BC development, emphasizing the role of new omics fields related to BC exposomics, such as environmental toxicogenomics, epigenomics and interactomics, metagenomics, nutrigenomics, nutriproteomics, and nutrimiRomics. We are mainly focused on food and nutrition, as well as endocrine-disrupting chemicals (EDCs), involved in BC development. Overall, cell and tissue accumulation and xenobiotic metabolism or biotransformation can lead to modifications in breast tissue composition and breast cell morphology, DNA damage and genomic instability, epimutations, RNA-mediated and extracellular vesicle effects, aberrant blood methylation, stimulation of epithelial–mesenchymal transition (EMT), disruption of cell–cell junctions, reorganization of the actin cytoskeleton, metabolic reprogramming, and overexpression of mesenchymal genes. Moreover, the metabolism of xenobiotics into BC cells impacts almost all known carcinogenic pathways. Conversely, in our food, there are many bioactive compounds with anti-cancer potential, exerting pro-apoptotic roles, inhibiting cell cycle progression and proliferation, migration, invasion, DNA damage, and cell stress conditions. We can conclude that exposomics has a high potential to demonstrate how environmental exposure to xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis in BC.

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Residential ultraviolet radiation and breast cancer risk in a large prospective cohort

Cited by 6 publications

References 59 publications

Workplace exposure to UV radiation and strategies to minimize cancer risk

Workplace exposure to UV radiation and strategies to minimize cancer risk

Impacts of socioeconomic and environmental factors on neoplasms incidence rates using machine learning and GIS: a cross-sectional study in Iran

Breast Cancer Exposomics

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